FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912987559> ?p ?o ?g. }

• W2912987559 endingPage "S890" @default.
• W2912987559 startingPage "S890" @default.
• W2912987559 abstract "Achalasia is an idiopathic disorder characterized by absent esophageal contractility and failure of lower esophageal sphincter relaxation. An identical clinical picture, termed pseudoachalasia, can be caused by benign or malignant disease processes at the gastroesophageal (GE) junction, including peptic strictures, post-surgical changes, and tumors. Less commonly, pseudoachalasia can be a result of a paraneoplastic phenomenon. Here, we present a case of small cell lung cancer (SCLC) presenting as dysphagia secondary to paraneoplastic pseudoachalasia. A 64-year-old female with a 40 pack-year smoking history presented with 5 months of progressive dysphagia to both solids and liquids, associated with regurgitation and a 45-kg weight loss. She also noted upper and lower extremity weakness and paresthesias. A barium esophagram demonstrated a dilated esophagus with a ‘bird beak' appearance of the GE junction. Subsequent esophagogastroduodenoscopy (EGD) confirmed that the narrowing was functional and not from obstruction. High resolution impedance manometry showed impaired LES relaxation and panesophageal pressurization consistent with type 2 achalasia. A CT scan of the chest revealed a left hilar mass, and pathology obtained via transbronchial needle aspiration was consistent with SCLC. A paraneoplastic panel was positive for Anti-Neuronal Nuclear Antibody-1 (ANNA-1), as well as N- and P/Q-type voltage gated calcium channel (VGCC) antibodies. Neurologic investigation with electromyography showed both a peripheral neuropathy and myelopathy. She underwent EGD with botulinum toxin injection of the LES, with moderate improvement in her dysphagia, after which definitive therapy for SCLC with chemoradiation was initiated. Pseudoachalasia secondary to a paraneoplastic syndrome is a rare diagnosis. It has been associated with a wide range of malignancies including esophageal, gastric, prostate, and lung cancers, with non-SCLC more commonly seen than SCLC. Multiple auto-antibodies have been implicated, including ANNA-1 and N- and P/Q-type VGCC antibodies, but to our knowledge, the presence of all three antibodies simultaneously is a novel finding. While neurologic symptoms are most common, a minority of patients will initially present with gastrointestinal dysmotility, including achalasia. In these patients, testing for paraneoplastic auto-antibodies should be considered, and investigation for an underlying malignancy should be pursued.Figure: Barium esophagram demonstrating a dilated esophagus with a ‘bird beak' appearance of the GE junction." @default.
• W2912987559 created "2019-02-21" @default.
• W2912987559 creator A5003329556 @default.
• W2912987559 creator A5031860326 @default.
• W2912987559 creator A5058394211 @default.
• W2912987559 date "2017-10-01" @default.
• W2912987559 modified "2023-09-25" @default.
• W2912987559 title "Paraneoplastic Pseudoachalasia: An Uncommon Presentation of Malignancy" @default.
• W2912987559 doi "https://doi.org/10.14309/00000434-201710001-01647" @default.
• W2912987559 hasPublicationYear "2017" @default.
• W2912987559 type Work @default.
• W2912987559 sameAs 2912987559 @default.
• W2912987559 citedByCount "0" @default.
• W2912987559 crossrefType "journal-article" @default.
• W2912987559 hasAuthorship W2912987559A5003329556 @default.
• W2912987559 hasAuthorship W2912987559A5031860326 @default.
• W2912987559 hasAuthorship W2912987559A5058394211 @default.
• W2912987559 hasConcept C112497637 @default.
• W2912987559 hasConcept C118552586 @default.
• W2912987559 hasConcept C126322002 @default.
• W2912987559 hasConcept C126838900 @default.
• W2912987559 hasConcept C2777604421 @default.
• W2912987559 hasConcept C2777819096 @default.
• W2912987559 hasConcept C2778451229 @default.
• W2912987559 hasConcept C2778704086 @default.
• W2912987559 hasConcept C2779399171 @default.
• W2912987559 hasConcept C2779958274 @default.
• W2912987559 hasConcept C2780596822 @default.
• W2912987559 hasConcept C2780775167 @default.
• W2912987559 hasConcept C2781143854 @default.
• W2912987559 hasConcept C71924100 @default.
• W2912987559 hasConceptScore W2912987559C112497637 @default.
• W2912987559 hasConceptScore W2912987559C118552586 @default.
• W2912987559 hasConceptScore W2912987559C126322002 @default.
• W2912987559 hasConceptScore W2912987559C126838900 @default.
• W2912987559 hasConceptScore W2912987559C2777604421 @default.
• W2912987559 hasConceptScore W2912987559C2777819096 @default.
• W2912987559 hasConceptScore W2912987559C2778451229 @default.
• W2912987559 hasConceptScore W2912987559C2778704086 @default.
• W2912987559 hasConceptScore W2912987559C2779399171 @default.
• W2912987559 hasConceptScore W2912987559C2779958274 @default.
• W2912987559 hasConceptScore W2912987559C2780596822 @default.
• W2912987559 hasConceptScore W2912987559C2780775167 @default.
• W2912987559 hasConceptScore W2912987559C2781143854 @default.
• W2912987559 hasConceptScore W2912987559C71924100 @default.
• W2912987559 hasLocation W29129875591 @default.
• W2912987559 hasOpenAccess W2912987559 @default.
• W2912987559 hasPrimaryLocation W29129875591 @default.
• W2912987559 hasRelatedWork W1574817264 @default.
• W2912987559 hasRelatedWork W2058486165 @default.
• W2912987559 hasRelatedWork W2086920958 @default.
• W2912987559 hasRelatedWork W2419568335 @default.
• W2912987559 hasRelatedWork W2603241006 @default.
• W2912987559 hasRelatedWork W2761250415 @default.
• W2912987559 hasRelatedWork W3059714066 @default.
• W2912987559 hasRelatedWork W3204468090 @default.
• W2912987559 hasRelatedWork W4210693775 @default.
• W2912987559 hasRelatedWork W7220239 @default.
• W2912987559 hasVolume "112" @default.
• W2912987559 isParatext "false" @default.
• W2912987559 isRetracted "false" @default.
• W2912987559 magId "2912987559" @default.
• W2912987559 workType "article" @default.