FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912989251> ?p ?o ?g. }

• W2912989251 endingPage "763" @default.
• W2912989251 startingPage "758" @default.
• W2912989251 abstract "INTRODUCTION: Cross-sectional data note lower levels of testosterone and sex hormone–binding globulin (SHBG) levels in men with nonalcoholic fatty liver disease (NAFLD). Whether sex hormone levels in young men are predictive of later risk of NAFLD is not known. METHODS: Among men in the prospective population-based multicenter Coronary Artery Risk Development in Young Adults study (mean age 50; n = 837), we assessed whether testosterone and SHBG levels measured at study year 10 (median age 35 years) were associated with prevalent NAFLD at study year 25. NAFLD was defined using noncontrast abdominal computed tomography (CT) scan after excluding other causes of hepatic steatosis. The association of testosterone and SHBG with prevalent NAFLD was assessed by logistic regression. RESULTS: Total testosterone levels in young men were inversely associated with subsequent prevalent NAFLD on unadjusted analysis (odds ratio [OR] 0.64, 95% confidence interval 0.53–0.7, P < 0.001), although no longer significant after adjustment for year 10 metabolic covariates as well as change in metabolic covariates from years 10 to 25 (OR 0.99, 95% confidence interval 0.76–1.27). In contrast, there was a significant inverse association of SHBG with prevalent NAFLD, independent of testosterone and metabolic covariates (OR 0.68, OR 0.51–0.92, P = 0.013). On formal mediation testing, visceral adiposity was found to explain ∼41.0% (95% confidence interval 27%–73%) of the association of lower SHBG with prevalent NAFLD. CONCLUSIONS: Lower levels of SHBG in young men are associated with increase in prevalent NAFLD in middle age, independent of comprehensive metabolic risk factors. SHBG may provide a novel marker of NAFLD risk in young men." @default.
• W2912989251 created "2019-02-21" @default.
• W2912989251 creator A5005915006 @default.
• W2912989251 creator A5016102803 @default.
• W2912989251 creator A5019470247 @default.
• W2912989251 creator A5045544656 @default.
• W2912989251 creator A5054001184 @default.
• W2912989251 creator A5069988352 @default.
• W2912989251 creator A5078574182 @default.
• W2912989251 creator A5085770998 @default.
• W2912989251 date "2019-02-04" @default.
• W2912989251 modified "2023-09-30" @default.
• W2912989251 title "Sex Hormone–Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife" @default.
• W2912989251 cites W1535600844 @default.
• W2912989251 cites W1551483441 @default.
• W2912989251 cites W1590490407 @default.
• W2912989251 cites W159814998 @default.
• W2912989251 cites W1900651926 @default.
• W2912989251 cites W1975271432 @default.
• W2912989251 cites W1981476069 @default.
• W2912989251 cites W1981843591 @default.
• W2912989251 cites W1989698691 @default.
• W2912989251 cites W1995461319 @default.
• W2912989251 cites W1997935836 @default.
• W2912989251 cites W2011726797 @default.
• W2912989251 cites W2018549749 @default.
• W2912989251 cites W2029896592 @default.
• W2912989251 cites W2036203117 @default.
• W2912989251 cites W2059619447 @default.
• W2912989251 cites W2076645058 @default.
• W2912989251 cites W2098247759 @default.
• W2912989251 cites W2102179430 @default.
• W2912989251 cites W2108646971 @default.
• W2912989251 cites W2109780493 @default.
• W2912989251 cites W2113281585 @default.
• W2912989251 cites W2123512407 @default.
• W2912989251 cites W2142908894 @default.
• W2912989251 cites W2144279110 @default.
• W2912989251 cites W2146511410 @default.
• W2912989251 cites W2208778639 @default.
• W2912989251 cites W2611908762 @default.
• W2912989251 cites W2753556422 @default.
• W2912989251 cites W2803086704 @default.
• W2912989251 cites W2844435616 @default.
• W2912989251 cites W4242526017 @default.
• W2912989251 doi "https://doi.org/10.14309/ajg.0000000000000138" @default.
• W2912989251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599461" @default.
• W2912989251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30730350" @default.
• W2912989251 hasPublicationYear "2019" @default.
• W2912989251 type Work @default.
• W2912989251 sameAs 2912989251 @default.
• W2912989251 citedByCount "19" @default.
• W2912989251 countsByYear W29129892512019 @default.
• W2912989251 countsByYear W29129892512020 @default.
• W2912989251 countsByYear W29129892512021 @default.
• W2912989251 countsByYear W29129892512022 @default.
• W2912989251 countsByYear W29129892512023 @default.
• W2912989251 crossrefType "journal-article" @default.
• W2912989251 hasAuthorship W2912989251A5005915006 @default.
• W2912989251 hasAuthorship W2912989251A5016102803 @default.
• W2912989251 hasAuthorship W2912989251A5019470247 @default.
• W2912989251 hasAuthorship W2912989251A5045544656 @default.
• W2912989251 hasAuthorship W2912989251A5054001184 @default.
• W2912989251 hasAuthorship W2912989251A5069988352 @default.
• W2912989251 hasAuthorship W2912989251A5078574182 @default.
• W2912989251 hasAuthorship W2912989251A5085770998 @default.
• W2912989251 hasBestOaLocation W29129892511 @default.
• W2912989251 hasConcept C126322002 @default.
• W2912989251 hasConcept C134018914 @default.
• W2912989251 hasConcept C156957248 @default.
• W2912989251 hasConcept C2776954865 @default.
• W2912989251 hasConcept C2777911890 @default.
• W2912989251 hasConcept C2778772119 @default.
• W2912989251 hasConcept C2779134260 @default.
• W2912989251 hasConcept C2779279991 @default.
• W2912989251 hasConcept C2779874844 @default.
• W2912989251 hasConcept C2908647359 @default.
• W2912989251 hasConcept C30092816 @default.
• W2912989251 hasConcept C44249647 @default.
• W2912989251 hasConcept C71315377 @default.
• W2912989251 hasConcept C71924100 @default.
• W2912989251 hasConcept C99454951 @default.
• W2912989251 hasConceptScore W2912989251C126322002 @default.
• W2912989251 hasConceptScore W2912989251C134018914 @default.
• W2912989251 hasConceptScore W2912989251C156957248 @default.
• W2912989251 hasConceptScore W2912989251C2776954865 @default.
• W2912989251 hasConceptScore W2912989251C2777911890 @default.
• W2912989251 hasConceptScore W2912989251C2778772119 @default.
• W2912989251 hasConceptScore W2912989251C2779134260 @default.
• W2912989251 hasConceptScore W2912989251C2779279991 @default.
• W2912989251 hasConceptScore W2912989251C2779874844 @default.
• W2912989251 hasConceptScore W2912989251C2908647359 @default.
• W2912989251 hasConceptScore W2912989251C30092816 @default.
• W2912989251 hasConceptScore W2912989251C44249647 @default.
• W2912989251 hasConceptScore W2912989251C71315377 @default.
• W2912989251 hasConceptScore W2912989251C71924100 @default.
• W2912989251 hasConceptScore W2912989251C99454951 @default.
• W2912989251 hasIssue "5" @default.

• next