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- W2912991958 abstract "Plasma membrane separates the cells from its extracellular environment and modulates bidirectional signalling across it. The regulation of the chemical (composition) and physical (tension) properties of the membrane tunes the nature of the information transmitted across the bilayer. Membrane trafficking via endo-exocytic processes can modulate the chemical and physical (membrane tension) properties of the membrane and is in turn regulated by it. However, the specific cellular processes and molecular mechanisms behind this regulation are poorly understood. We have used multiple ways to modulate membrane tension, including a custom designed cell stretching device, to understand role of endocytic processes in membrane homeostasis. In parallel, we have utilized optical tweezers to measure membrane tension on modulating endocytosis. We find that lowering of membrane tension results in a passive membrane response and the excess membrane forms membrane tubules or invaginations that is subsequently resorbed by an active endocytic process. Although multiple endocytic pathways operate simultaneously at the cell surface, we find that a specific endocytic pathway, the dynamin-independent CLIC/GEEC (CG) endocytic pathway is transiently up regulated during change in membrane tension. By contrast, clathrin or caveolar pathways are not modulated. However, alteration in membrane tension does not directly modulate CG endocytosis. This modulation requires vinculin, a mechano-transducer recruited to focal adhesion in adherent cells. Vinculin acts by controlling the levels of a key regulator of the CG pathway, GBF1, at the plasma membrane. On the other hand, perturbing the CG pathway directly modulates membrane tension, suggesting that this cellular mechanism is likely to be involved in homeostatic control of membrane tension. These features suggest that the CG pathway could be a vital component of the cellular machinery that sets resting membrane tension and possibly maintain area homeostasis." @default.
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- W2912991958 date "2019-02-01" @default.
- W2912991958 modified "2023-10-16" @default.
- W2912991958 title "Mechanochemical Feedback Control of Dynamin Independent Endocytosis Modulates Membrane Tension in Adherent Cells" @default.
- W2912991958 doi "https://doi.org/10.1016/j.bpj.2018.11.542" @default.
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