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• W2912992372 abstract "Tryptophan 2,3-dioxygenase (TDO), an immunosuppressive enzyme, can involve in immune evasion and tumor tolerance. TDO inhibitors can boost the efficacy of chemotherapeutics by promoting immunity. Herein, a strategy to introduce a TDO inhibitor into Pt(IV) complexes for reversing tumor immune suppression was adopted. A mono-modified Pt(IV) complex, 3, displayed significant antitumor activity against human liver cancer cells. Flow cytometry study revealed that complex 3 could induce cell death via a mitochondrial-dependent apoptosis pathway and arrest the cell cycle at S phase. Furthermore, complex 3 was effective to enhance T-cell immune responses by inhibiting the TDO enzyme expression to block the kynurenine production and inactivating the downstream of aryl hydrocarbon receptor (AHR)." @default.
• W2912992372 created "2019-02-21" @default.
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• W2912992372 date "2019-06-01" @default.
• W2912992372 modified "2023-10-14" @default.
• W2912992372 title "Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators" @default.
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• W2912992372 doi "https://doi.org/10.1016/j.jinorgbio.2019.02.004" @default.
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