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• W2912992840 abstract "The codon stabilization coefficient (CSC) is derived from the correlation between each codon frequency in transcripts and mRNA half-life experimental data. In this work, we used this metric as a reference to compare previously published Saccharomyces cerevisiae mRNA half-life datasets and investigate how codon composition related to protein levels. We generated CSCs derived from nine studies. Four datasets produced similar CSCs, which also correlated with other independent parameters that reflected codon optimality, such as the tRNA abundance and ribosome residence time. By calculating the average CSC for each gene, we found that most mRNAs tended to have more non-optimal codons. Conversely, a high proportion of optimal codons was found for genes coding highly abundant proteins, including proteins that were only transiently overexpressed in response to stress conditions. We also used CSCs to identify and locate mRNA regions enriched in non-optimal codons. We found that these stretches were usually located close to the initiation codon and were sufficient to slow ribosome movement. However, in contrast to observations from reporter systems, we found no position-dependent effect on the mRNA half-life. These analyses underscore the value of CSCs in studies of mRNA stability and codon bias and their relationships with protein expression." @default.
• W2912992840 created "2019-02-21" @default.
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• W2912992840 date "2019-01-30" @default.
• W2912992840 modified "2023-10-16" @default.
• W2912992840 title "Codon stabilization coefficient as a metric to gain insights into mRNA stability and codon bias and their relationships with translation" @default.
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• W2912992840 doi "https://doi.org/10.1093/nar/gkz033" @default.
• W2912992840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6412131" @default.
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• W2912992840 hasPublicationYear "2019" @default.
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