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- W2912993645 abstract "Novel cyanine-based fluorescent probes for the detection of H2S were developed. The probes developed are stable under physiological conditions. The water soluble fluorescent probe 2 displayed ultrafast and specific response to H2S displaying NIR fluorescence of 115-fold turn-on with the detection limit of 11 nM without assistance of organic solvent or surfactant. Cell imaging experiments indicated that probe 2 was cell-permeable and was able to detect H2S sensitively in lysosomes. Moreover, our probe was able to detect H2S intrinsically produced H2S through enzymatic/non-enzymatic biosynthetic pathway from Cys/GSH. Moreover, we applied probe 2 to detect H2S in living mice and demonstrated the fast metabolism of H2S. Thus, probe 2 shows great promise as a reporter for H2S." @default.
- W2912993645 created "2019-02-21" @default.
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- W2912993645 date "2019-04-01" @default.
- W2912993645 modified "2023-10-14" @default.
- W2912993645 title "Instantaneous fluorescent probe for the specific detection of H2S" @default.
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- W2912993645 doi "https://doi.org/10.1016/j.saa.2019.01.085" @default.
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