Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912996384> ?p ?o ?g. }
- W2912996384 endingPage "116" @default.
- W2912996384 startingPage "108" @default.
- W2912996384 abstract "MAP kinases, CREB, and Tau are signaling molecules among downstream synaptic targets involved in synaptic function, memory formation and cognition.Here we investigate the neuro-protective effect of selenium in HFHCD induced tauopathy and cognitive impairment in rats. The study was focused on the effects on synaptic plasticity related molecules in hippocampus, which in turn may be the mechanism responsible for underlying behavior alterations.Rats were divided into 2 main groups: one fed with normal rat chow diet and the other with HFHCD for 6 weeks. Every group was subdivided into three subgroups, non-treated, low dose Se (200 μg/kg) and high dose Se (400 μg/kg). The cognitive behaviors of the rats were tested using the Morris Water Maze test, hole board and conditioned avoidance tests.Daily administration of Se decreased the observed memory impairment induced by HFHCD as measured by behavioral tests. It significantly alleviated oxidative stress and restored protein expression of cyclic AMP response element protein (CREB) and brain derived neurotrophic factor (BDNF) and reduced p-Tau in the hippocampus.Se reversed HFHCD-induced cognitive impairments via decrease expression of p38 MAPK that phosphorylate and aggregate Tau protein. Addition, It restored neuronal plasticity through increasing the expression of BDNF, and CREB in the hippocampus; thus, it can be considered as a possible beneficial therapeutic approach for prevention and treatment of HFHCD induced tauopathy and cognitive impairment, further studies are warranted in this field." @default.
- W2912996384 created "2019-02-21" @default.
- W2912996384 creator A5044599927 @default.
- W2912996384 creator A5085877502 @default.
- W2912996384 date "2019-04-01" @default.
- W2912996384 modified "2023-10-14" @default.
- W2912996384 title "The role of MAPK signaling pathway in selenium amelioration of high fat/high cholesterol diet-induced tauopathy in rats" @default.
- W2912996384 cites W1500350553 @default.
- W2912996384 cites W1532762518 @default.
- W2912996384 cites W168911629 @default.
- W2912996384 cites W1824724965 @default.
- W2912996384 cites W1933444002 @default.
- W2912996384 cites W1948557773 @default.
- W2912996384 cites W1965318694 @default.
- W2912996384 cites W1970686195 @default.
- W2912996384 cites W1973865177 @default.
- W2912996384 cites W1982761508 @default.
- W2912996384 cites W1984551681 @default.
- W2912996384 cites W1994801797 @default.
- W2912996384 cites W1997814051 @default.
- W2912996384 cites W1999898236 @default.
- W2912996384 cites W2001894948 @default.
- W2912996384 cites W2005927707 @default.
- W2912996384 cites W2009894419 @default.
- W2912996384 cites W2011965698 @default.
- W2912996384 cites W2013775280 @default.
- W2912996384 cites W2014030276 @default.
- W2912996384 cites W2015933608 @default.
- W2912996384 cites W2020417786 @default.
- W2912996384 cites W2025378252 @default.
- W2912996384 cites W2028247429 @default.
- W2912996384 cites W2028911700 @default.
- W2912996384 cites W2030067782 @default.
- W2912996384 cites W2035923900 @default.
- W2912996384 cites W2038962081 @default.
- W2912996384 cites W2043640933 @default.
- W2912996384 cites W2048865592 @default.
- W2912996384 cites W2049134173 @default.
- W2912996384 cites W2057042201 @default.
- W2912996384 cites W2063251245 @default.
- W2912996384 cites W2063849763 @default.
- W2912996384 cites W2070964117 @default.
- W2912996384 cites W2071305328 @default.
- W2912996384 cites W2072707752 @default.
- W2912996384 cites W2076279968 @default.
- W2912996384 cites W2081524299 @default.
- W2912996384 cites W2087465947 @default.
- W2912996384 cites W2093232740 @default.
- W2912996384 cites W2096410114 @default.
- W2912996384 cites W2099736697 @default.
- W2912996384 cites W2107419359 @default.
- W2912996384 cites W2120145202 @default.
- W2912996384 cites W2129659920 @default.
- W2912996384 cites W2133801172 @default.
- W2912996384 cites W2136725886 @default.
- W2912996384 cites W2145107163 @default.
- W2912996384 cites W2149937665 @default.
- W2912996384 cites W2153315121 @default.
- W2912996384 cites W2154513827 @default.
- W2912996384 cites W2154696002 @default.
- W2912996384 cites W2155967952 @default.
- W2912996384 cites W2157669984 @default.
- W2912996384 cites W2161207188 @default.
- W2912996384 cites W2171397809 @default.
- W2912996384 cites W2236031153 @default.
- W2912996384 cites W2429713509 @default.
- W2912996384 cites W244713839 @default.
- W2912996384 cites W2514934551 @default.
- W2912996384 cites W2525541800 @default.
- W2912996384 cites W2559579212 @default.
- W2912996384 cites W2576784305 @default.
- W2912996384 cites W2744319031 @default.
- W2912996384 cites W380069984 @default.
- W2912996384 cites W4296588155 @default.
- W2912996384 cites W84368649 @default.
- W2912996384 doi "https://doi.org/10.1016/j.cbi.2019.01.022" @default.
- W2912996384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30695686" @default.
- W2912996384 hasPublicationYear "2019" @default.
- W2912996384 type Work @default.
- W2912996384 sameAs 2912996384 @default.
- W2912996384 citedByCount "12" @default.
- W2912996384 countsByYear W29129963842019 @default.
- W2912996384 countsByYear W29129963842020 @default.
- W2912996384 countsByYear W29129963842021 @default.
- W2912996384 countsByYear W29129963842022 @default.
- W2912996384 countsByYear W29129963842023 @default.
- W2912996384 crossrefType "journal-article" @default.
- W2912996384 hasAuthorship W2912996384A5044599927 @default.
- W2912996384 hasAuthorship W2912996384A5085877502 @default.
- W2912996384 hasConcept C104317684 @default.
- W2912996384 hasConcept C11960822 @default.
- W2912996384 hasConcept C126322002 @default.
- W2912996384 hasConcept C134018914 @default.
- W2912996384 hasConcept C15744967 @default.
- W2912996384 hasConcept C160539049 @default.
- W2912996384 hasConcept C1629964 @default.
- W2912996384 hasConcept C169760540 @default.
- W2912996384 hasConcept C170493617 @default.