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- W2912996417 abstract "Summary DNA methylation and histone H1 mediate transcriptional silencing of genes and transposable elements, but how they interact is unclear. In plants and animals with mosaic genomic methylation, functionally mysterious methylation is also common within constitutively active housekeeping genes. Here we show that H1 is enriched in methylated sequences, including genes, of Arabidopsis thaliana , yet this enrichment is independent of DNA methylation. Loss of H1 disperses heterochromatin, globally alters nucleosome organization, and activates H1-bound genes, but only weakly de-represses transposable elements. However, H1 loss strongly activates transposable elements hypomethylated through mutation of DNA methyltransferase MET1 . Loss of H1 also activates antisense transcripts within demethylated genes. Our results demonstrate that H1 and DNA methylation cooperatively maintain transcriptional homeostasis by silencing transposable elements and aberrant intragenic transcripts. Such functionality plausibly explains why DNA methylation, a well-known mutagen, has been maintained within coding sequences of crucial plant and animal genes. Highlights Histone H1 is enriched in methylated DNA independently of methylation Loss of H1 activates genes, alters nucleosome organization and disperses heterochromatin DNA methylation and H1 jointly silence transposons DNA methylation and H1 cooperatively suppress intragenic antisense transcripts" @default.
- W2912996417 created "2019-02-21" @default.
- W2912996417 creator A5029356724 @default.
- W2912996417 creator A5038736027 @default.
- W2912996417 creator A5038968934 @default.
- W2912996417 creator A5064129953 @default.
- W2912996417 creator A5089216744 @default.
- W2912996417 date "2019-01-27" @default.
- W2912996417 modified "2023-10-12" @default.
- W2912996417 title "DNA methylation and histone H1 cooperatively repress transposable elements and aberrant intragenic transcripts" @default.
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