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- W2912996490 abstract "Stem-loop hairpins, a common DNA and RNA motif that are involved in many biological functions, are usually thermodynamically stable. Meanwhile, these hairpins can also be very dynamic microscopically with rapid conformational changes, which connect to the genomic instabilities such as trinucleotide repeat expansions that responsible for several neurodegenerative diseases. Here, we studied the structural dynamics of tandem dCTG repeats at the single-molecule level. We found that the odd-numbered d(CTG)n (n denotes the repeat number, n = 13-37) hairpins undergo stochastic conformation interconversions between blunt-end and overhang configurations. Throughout the repeat-number-dependent kinetic analysis, we proposed a loop-initiated bulge diffusion model, where a bulge is initially prepared at the loop followed by the diffusion through the stem, and ultimately complete the conformation change. This model was further supported by our Monte Carlo simulations. With this model, we can reasonably extrapolate the dynamic slippery hairpin reconfiguration, which is believed to be crucial in repeat expansion, to a longer and pathological-relevant hairpins." @default.
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- W2912996490 date "2019-02-01" @default.
- W2912996490 modified "2023-09-26" @default.
- W2912996490 title "Long-Range Slippery Hairpin Reconfiguration and its Mechanism in Trinucleotide Repeats Revealed by Single-Molecule Spectroscopy" @default.
- W2912996490 doi "https://doi.org/10.1016/j.bpj.2018.11.2700" @default.
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