FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912996992> ?p ?o ?g. }

• W2912996992 abstract "The generation of neuronal diversity is essential for circuit formation and behavior. Morphological differences in sequentially born neurons could be due to intrinsic molecular identity specified by temporal transcription factors (henceforth called intrinsic temporal identity) or due to changing extrinsic cues. Here we use the Drosophila NB7-1 lineage to address this question. NB7-1 generates the U1-U5 motor neurons sequentially; each has a distinct intrinsic temporal identity due to inheritance of different temporal transcription factors at its time of birth. Here we show that the U1-U5 neurons project axons sequentially, followed by sequential dendrite extension. We misexpress the earliest temporal transcription factor, Hunchback, to create “ectopic” U1 neurons with an early intrinsic temporal identity but later birth-order. These ectopic U1 neurons have axon muscle targeting and dendrite neuropil targeting consistent with U1 intrinsic temporal identity, rather than their time of birth or differentiation. We conclude that intrinsic temporal identity plays a major role in establishing both motor axon muscle targeting and dendritic arbor targeting, which are required for proper motor circuit development." @default.
• W2912996992 created "2019-02-21" @default.
• W2912996992 creator A5059592074 @default.
• W2912996992 creator A5077877871 @default.
• W2912996992 date "2019-01-01" @default.
• W2912996992 modified "2023-10-12" @default.
• W2912996992 title "The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in <i>Drosophila</i>" @default.
• W2912996992 cites W121396268 @default.
• W2912996992 cites W1491075702 @default.
• W2912996992 cites W1493583608 @default.
• W2912996992 cites W1575064426 @default.
• W2912996992 cites W1612533268 @default.
• W2912996992 cites W1646072195 @default.
• W2912996992 cites W1892652257 @default.
• W2912996992 cites W1910303268 @default.
• W2912996992 cites W1966075007 @default.
• W2912996992 cites W1985287403 @default.
• W2912996992 cites W1999149787 @default.
• W2912996992 cites W2003437721 @default.
• W2912996992 cites W2006700032 @default.
• W2912996992 cites W2012485040 @default.
• W2912996992 cites W2014042411 @default.
• W2912996992 cites W2016817019 @default.
• W2912996992 cites W2020046465 @default.
• W2912996992 cites W2021892293 @default.
• W2912996992 cites W2024185372 @default.
• W2912996992 cites W2025061053 @default.
• W2912996992 cites W2026175377 @default.
• W2912996992 cites W2026833123 @default.
• W2912996992 cites W2035663812 @default.
• W2912996992 cites W2039728034 @default.
• W2912996992 cites W2053564909 @default.
• W2912996992 cites W2060943078 @default.
• W2912996992 cites W2061614102 @default.
• W2912996992 cites W2074225039 @default.
• W2912996992 cites W2074566935 @default.
• W2912996992 cites W2075433744 @default.
• W2912996992 cites W2087091643 @default.
• W2912996992 cites W2087543137 @default.
• W2912996992 cites W2089598899 @default.
• W2912996992 cites W2090435424 @default.
• W2912996992 cites W2091138883 @default.
• W2912996992 cites W2093948087 @default.
• W2912996992 cites W2102118135 @default.
• W2912996992 cites W2120674205 @default.
• W2912996992 cites W2128185645 @default.
• W2912996992 cites W2133889652 @default.
• W2912996992 cites W2149670621 @default.
• W2912996992 cites W2161396457 @default.
• W2912996992 cites W2169062325 @default.
• W2912996992 cites W2171888964 @default.
• W2912996992 cites W2179346095 @default.
• W2912996992 cites W2225257929 @default.
• W2912996992 cites W2314151096 @default.
• W2912996992 cites W2562589097 @default.
• W2912996992 cites W2564314293 @default.
• W2912996992 cites W2579394006 @default.
• W2912996992 cites W2602603611 @default.
• W2912996992 cites W2602878009 @default.
• W2912996992 cites W2605749037 @default.
• W2912996992 cites W2615767183 @default.
• W2912996992 cites W2620197790 @default.
• W2912996992 cites W2775596360 @default.
• W2912996992 cites W2917789834 @default.
• W2912996992 cites W2951641862 @default.
• W2912996992 cites W2952677649 @default.
• W2912996992 cites W2972726934 @default.
• W2912996992 doi "https://doi.org/10.1242/dev.175570" @default.
• W2912996992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6467472" @default.
• W2912996992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30890568" @default.
• W2912996992 hasPublicationYear "2019" @default.
• W2912996992 type Work @default.
• W2912996992 sameAs 2912996992 @default.
• W2912996992 citedByCount "24" @default.
• W2912996992 countsByYear W29129969922019 @default.
• W2912996992 countsByYear W29129969922020 @default.
• W2912996992 countsByYear W29129969922021 @default.
• W2912996992 countsByYear W29129969922022 @default.
• W2912996992 countsByYear W29129969922023 @default.
• W2912996992 crossrefType "journal-article" @default.
• W2912996992 hasAuthorship W2912996992A5059592074 @default.
• W2912996992 hasAuthorship W2912996992A5077877871 @default.
• W2912996992 hasBestOaLocation W29129969921 @default.
• W2912996992 hasConcept C104317684 @default.
• W2912996992 hasConcept C169760540 @default.
• W2912996992 hasConcept C2524010 @default.
• W2912996992 hasConcept C2777569460 @default.
• W2912996992 hasConcept C2777831001 @default.
• W2912996992 hasConcept C2779422922 @default.
• W2912996992 hasConcept C2779530196 @default.
• W2912996992 hasConcept C2779617337 @default.
• W2912996992 hasConcept C33923547 @default.
• W2912996992 hasConcept C529278444 @default.
• W2912996992 hasConcept C54355233 @default.
• W2912996992 hasConcept C55493867 @default.
• W2912996992 hasConcept C84248122 @default.
• W2912996992 hasConcept C86339819 @default.
• W2912996992 hasConcept C86803240 @default.
• W2912996992 hasConceptScore W2912996992C104317684 @default.
• W2912996992 hasConceptScore W2912996992C169760540 @default.

• next