Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912997294> ?p ?o ?g. }
- W2912997294 endingPage "1691" @default.
- W2912997294 startingPage "1669" @default.
- W2912997294 abstract "The nucleo-mitochondrial dual-localized proteins can act as gene expression regulators; however, few instances of these proteins have been described in plants. Arabidopsis (Arabidopsis thaliana) PROHIBITIN 3 (PHB3) is involved in stress responses and developmental processes, but it is unknown how these roles are achieved at the molecular level in the nucleus. In this study, we show that nucleo-mitochondrial PHB3 plays an essential role in regulating genome stability and cell proliferation. PHB3 is up-regulated by DNA damage agents, and the stress-induced PHB3 proteins accumulate in the nucleus. Loss of function of PHB3 results in DNA damage and defective maintenance of the root stem cell niche. Subsequently, the expression patterns and levels of the root stem cell regulators are altered and down-regulated, respectively. In addition, the phb3 mutant shows aberrant cell division and altered expression of cell cycle–related genes, such as CycB1 and Cyclin dependent kinase 1. Moreover, the minichromosome maintenance (MCM) genes, e.g. MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7, are up-regulated in the phb3 mutant. Reducing the MCM2 expression level substantially recovers the DNA damage in the phb3 mutant and partially rescues the altered cell proliferation and root deficiency of phb3 seedlings. PHB3 acts as a transcriptional coregulator that represses MCM2 expression by competitively binding to the promoter E2F–cis-acting elements with E2Fa so as to modulate primary root growth. Collectively, these findings indicate that nuclear-localized PHB3 acts as a transcriptional coregulator that suppresses MCM2 expression to sustain genome integrity and cell proliferation for stem cell niche maintenance in Arabidopsis." @default.
- W2912997294 created "2019-02-21" @default.
- W2912997294 creator A5009393372 @default.
- W2912997294 creator A5035108007 @default.
- W2912997294 creator A5052408042 @default.
- W2912997294 creator A5055838753 @default.
- W2912997294 creator A5056900160 @default.
- W2912997294 creator A5066685787 @default.
- W2912997294 creator A5071857438 @default.
- W2912997294 creator A5091006151 @default.
- W2912997294 date "2019-01-23" @default.
- W2912997294 modified "2023-10-15" @default.
- W2912997294 title "Nuclear Prohibitin3 Maintains Genome Integrity and Cell Proliferation in the Root Meristem through Minichromosome Maintenance 2" @default.
- W2912997294 cites W1505270625 @default.
- W2912997294 cites W1665024321 @default.
- W2912997294 cites W1899903779 @default.
- W2912997294 cites W1966433403 @default.
- W2912997294 cites W1966665626 @default.
- W2912997294 cites W1968077350 @default.
- W2912997294 cites W1969277430 @default.
- W2912997294 cites W1971826767 @default.
- W2912997294 cites W1979212911 @default.
- W2912997294 cites W1981053040 @default.
- W2912997294 cites W1981707807 @default.
- W2912997294 cites W1989619407 @default.
- W2912997294 cites W1989665806 @default.
- W2912997294 cites W1996439701 @default.
- W2912997294 cites W1997096620 @default.
- W2912997294 cites W2003946724 @default.
- W2912997294 cites W2005450791 @default.
- W2912997294 cites W2008642796 @default.
- W2912997294 cites W2010093414 @default.
- W2912997294 cites W2010233116 @default.
- W2912997294 cites W2010277992 @default.
- W2912997294 cites W2015739327 @default.
- W2912997294 cites W2018148749 @default.
- W2912997294 cites W2019092505 @default.
- W2912997294 cites W2027577154 @default.
- W2912997294 cites W2031753415 @default.
- W2912997294 cites W2032152188 @default.
- W2912997294 cites W2032428569 @default.
- W2912997294 cites W2047012581 @default.
- W2912997294 cites W2047068929 @default.
- W2912997294 cites W2048479722 @default.
- W2912997294 cites W2052821301 @default.
- W2912997294 cites W2053536499 @default.
- W2912997294 cites W2056366454 @default.
- W2912997294 cites W2056996163 @default.
- W2912997294 cites W2057294335 @default.
- W2912997294 cites W2057896961 @default.
- W2912997294 cites W2059373490 @default.
- W2912997294 cites W2059876119 @default.
- W2912997294 cites W2060143140 @default.
- W2912997294 cites W2062732100 @default.
- W2912997294 cites W2062908935 @default.
- W2912997294 cites W2063268362 @default.
- W2912997294 cites W2069447759 @default.
- W2912997294 cites W2069682761 @default.
- W2912997294 cites W2070479337 @default.
- W2912997294 cites W2071326354 @default.
- W2912997294 cites W2072344795 @default.
- W2912997294 cites W2079589921 @default.
- W2912997294 cites W2080198621 @default.
- W2912997294 cites W2080432620 @default.
- W2912997294 cites W2084437888 @default.
- W2912997294 cites W2086660631 @default.
- W2912997294 cites W2088924033 @default.
- W2912997294 cites W2090772326 @default.
- W2912997294 cites W2093287028 @default.
- W2912997294 cites W2093835454 @default.
- W2912997294 cites W2095115211 @default.
- W2912997294 cites W2096340818 @default.
- W2912997294 cites W2097741132 @default.
- W2912997294 cites W2100178337 @default.
- W2912997294 cites W2100541085 @default.
- W2912997294 cites W2102026216 @default.
- W2912997294 cites W2103744954 @default.
- W2912997294 cites W2103759508 @default.
- W2912997294 cites W2111094915 @default.
- W2912997294 cites W2116163614 @default.
- W2912997294 cites W2116183942 @default.
- W2912997294 cites W2117687474 @default.
- W2912997294 cites W2118331296 @default.
- W2912997294 cites W2119195901 @default.
- W2912997294 cites W2119931973 @default.
- W2912997294 cites W2120030399 @default.
- W2912997294 cites W2120692165 @default.
- W2912997294 cites W2129290303 @default.
- W2912997294 cites W2130455718 @default.
- W2912997294 cites W2133955384 @default.
- W2912997294 cites W2134871133 @default.
- W2912997294 cites W2137231405 @default.
- W2912997294 cites W2138104385 @default.
- W2912997294 cites W2139694094 @default.
- W2912997294 cites W2144309696 @default.
- W2912997294 cites W2145200068 @default.
- W2912997294 cites W2145293904 @default.
- W2912997294 cites W2145754788 @default.