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- W2912997505 endingPage "212" @default.
- W2912997505 startingPage "196" @default.
- W2912997505 abstract "Humoral regulation by ligand/receptor interactions is a fundamental feature of vertebrate hematopoiesis. Zebrafish are an established vertebrate animal model of hematopoiesis, sharing with mammals conserved genetic, molecular and cell biological regulatory mechanisms. This comprehensive review considers zebrafish hematopoiesis from the perspective of the hematopoietic growth factors (HGFs), their receptors and their actions. Zebrafish possess multiple HGFs: CSF1 (M-CSF) and CSF3 (G-CSF), kit ligand (KL, SCF), erythropoietin (EPO), thrombopoietin (THPO/TPO), and the interleukins IL6, IL11, and IL34. Some ligands and/or receptor components have been duplicated by various mechanisms including the teleost whole genome duplication, adding complexity to the ligand/receptor interactions possible, but also providing examples of several different outcomes of ligand and receptor subfunctionalization or neofunctionalization. CSF2 (GM-CSF), IL3 and IL5 and their receptors are absent from zebrafish. Overall the humoral regulation of hematopoiesis in zebrafish displays considerable similarity with mammals, which can be applied in biological and disease modelling research." @default.
- W2912997505 created "2019-02-21" @default.
- W2912997505 creator A5044014434 @default.
- W2912997505 creator A5072824808 @default.
- W2912997505 date "2018-11-02" @default.
- W2912997505 modified "2023-09-27" @default.
- W2912997505 title "Hematopoietic growth factors: the scenario in zebrafish" @default.
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