FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912997608> ?p ?o ?g. }

• W2912997608 endingPage "S1259" @default.
• W2912997608 startingPage "S1258" @default.
• W2912997608 abstract "Introduction: Drug toxicity and viral hepatitis are the most common causes of ALF. A rarely reported cause of ALF is malignant infiltration of the liver due to either a solid organ tumor or hematological malignancy. Here we present a case of an ALF in a breast cancer patient. Case: 80 year old woman diagnosed with invasive ductal carcinoma of the breast, estrogen receptor positive, progesterone receptor negative & HER2 negative and was started on anastrozole in view of her advanced age and comorbidities. She was then admitted to the hospital for altered mental status, fatigue, and abdominal pain. Initial laboratory assessment showed derangement of liver test showing alkaline phosphatase (ALP): 517, aspartate aminotransferase (AST): 687, alanine transaminase (ALT):171, total bilirubin 5.2, INR 1.9. Hepatitis panel and autoimmune panel were unremarkable. Abdominal ultrasound revealed heterogeneous nodular liver without biliary ductal dilatation and mild ascites. No focal hepatic lesion was noted. Patient's liver function continued to deteriorate despite avoidance of hepatotoxic medications including anastrozole. Laboratory findings on hospital day 10 showed ALP: 406, AST: 1099, ALT: 247, INR 4.4. Provisional diagnosis of pseudocirrhosis was made in the setting of breast cancer without history of chronic liver disease. Liver biopsy was not pursued for the lack of definite therapeutic benefit. Patient was discharged to hospice in view of poor prognosis. Patient died of multiorgan failure due to fulminant hepatic failure.Table: Table. Laboratory valuesDiscussion: Clinically severe hepatic dysfunction with coagulopathy and encephalopathy because of metastatic tumor involvement is rare. Liver metastases usually present as radiographically detectable lesions that do not significantly compromise liver function. Rarely, metastatic carcinoma can diffusely infiltrate hepatic sinusoids, a pattern of metastasis that may be missed on imaging studies, and can result in liver failure. ‘Pseudocirrhosis' refers to morphological changes of the liver that mimic cirrhosis without histological changes caused by hepatic metastasis in setting of chemotherapy. The common malignancies are breast cancer, lymphoma or leukemia, colon cancer and others are rare. Prognosis is poor with after hospitalization mortality rate reported between 90-100%. The diagnosis of ALF secondary to malignancy can be challenging and may elude clinicians initially, particularly in patients with no previous cancer history." @default.
• W2912997608 created "2019-02-21" @default.
• W2912997608 creator A5049632967 @default.
• W2912997608 creator A5055405300 @default.
• W2912997608 creator A5069625128 @default.
• W2912997608 creator A5077187108 @default.
• W2912997608 creator A5085700555 @default.
• W2912997608 date "2017-10-01" @default.
• W2912997608 modified "2023-09-26" @default.
• W2912997608 title "Pseudocirrhosis: A Cause of Acute Liver Failure (ALF)" @default.
• W2912997608 doi "https://doi.org/10.14309/00000434-201710001-02298" @default.
• W2912997608 hasPublicationYear "2017" @default.
• W2912997608 type Work @default.
• W2912997608 sameAs 2912997608 @default.
• W2912997608 citedByCount "1" @default.
• W2912997608 countsByYear W29129976082022 @default.
• W2912997608 crossrefType "journal-article" @default.
• W2912997608 hasAuthorship W2912997608A5049632967 @default.
• W2912997608 hasAuthorship W2912997608A5055405300 @default.
• W2912997608 hasAuthorship W2912997608A5069625128 @default.
• W2912997608 hasAuthorship W2912997608A5077187108 @default.
• W2912997608 hasAuthorship W2912997608A5085700555 @default.
• W2912997608 hasConcept C126322002 @default.
• W2912997608 hasConcept C142724271 @default.
• W2912997608 hasConcept C2776029263 @default.
• W2912997608 hasConcept C2777075537 @default.
• W2912997608 hasConcept C2778351090 @default.
• W2912997608 hasConcept C2779609443 @default.
• W2912997608 hasConcept C2780496750 @default.
• W2912997608 hasConcept C2911091166 @default.
• W2912997608 hasConcept C2911118192 @default.
• W2912997608 hasConcept C2992208098 @default.
• W2912997608 hasConcept C512861765 @default.
• W2912997608 hasConcept C71924100 @default.
• W2912997608 hasConcept C90924648 @default.
• W2912997608 hasConceptScore W2912997608C126322002 @default.
• W2912997608 hasConceptScore W2912997608C142724271 @default.
• W2912997608 hasConceptScore W2912997608C2776029263 @default.
• W2912997608 hasConceptScore W2912997608C2777075537 @default.
• W2912997608 hasConceptScore W2912997608C2778351090 @default.
• W2912997608 hasConceptScore W2912997608C2779609443 @default.
• W2912997608 hasConceptScore W2912997608C2780496750 @default.
• W2912997608 hasConceptScore W2912997608C2911091166 @default.
• W2912997608 hasConceptScore W2912997608C2911118192 @default.
• W2912997608 hasConceptScore W2912997608C2992208098 @default.
• W2912997608 hasConceptScore W2912997608C512861765 @default.
• W2912997608 hasConceptScore W2912997608C71924100 @default.
• W2912997608 hasConceptScore W2912997608C90924648 @default.
• W2912997608 hasLocation W29129976081 @default.
• W2912997608 hasOpenAccess W2912997608 @default.
• W2912997608 hasPrimaryLocation W29129976081 @default.
• W2912997608 hasRelatedWork W148462880 @default.
• W2912997608 hasRelatedWork W207293852 @default.
• W2912997608 hasRelatedWork W2123302950 @default.
• W2912997608 hasRelatedWork W2128667410 @default.
• W2912997608 hasRelatedWork W2152547360 @default.
• W2912997608 hasRelatedWork W2391710804 @default.
• W2912997608 hasRelatedWork W2744224482 @default.
• W2912997608 hasRelatedWork W3028908109 @default.
• W2912997608 hasRelatedWork W3193288805 @default.
• W2912997608 hasRelatedWork W83694583 @default.
• W2912997608 hasVolume "112" @default.
• W2912997608 isParatext "false" @default.
• W2912997608 isRetracted "false" @default.
• W2912997608 magId "2912997608" @default.
• W2912997608 workType "article" @default.