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• W2912998168 abstract "Objectives The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV /hepatitis C virus ( HCV )‐coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct‐acting antiviral ( DAA ) therapy. Methods Stages included in the continuum were as follows: anti‐ HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow‐up HCV RNA test, and cure. Sustained virological response ( SVR ) could only be assessed for those with a follow‐up HCV RNA test and was defined as a negative HCV RNA result measured > 12 or 24 weeks after stopping treatment. Results Numbers and percentages for the stages of the HCV continuum of care were as follows: anti‐ HCV positive ( n = 5173), HCV RNA tested (4207 of 5173; 81.3%), currently HCV RNA positive (3179 of 5173; 61.5%), ever HCV RNA positive ( n = 3876), initiated HCV treatment (1693 of 3876; 43.7%), completed HCV treatment (1598 of 3876; 41.2%), follow‐up HCV RNA test to allow SVR assessment (1195 of 3876; 30.8%), and cure (629 of 3876; 16.2%). The proportion that achieved SVR was 52.6% (629 of 1195). There were significant differences between regions at each stage of the continuum ( P < 0.0001). Conclusions In the proposed HCV continuum of care for HIV / HCV ‐coinfected individuals, we found major gaps at all stages, with almost 20% of anti‐ HCV ‐positive individuals having no documented HCV RNA test and a low proportion achieving SVR , in the pre‐ DAA era." @default.
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• W2912998168 date "2019-02-08" @default.
• W2912998168 modified "2023-10-14" @default.
• W2912998168 title "Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA" @default.
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• W2912998168 doi "https://doi.org/10.1111/hiv.12711" @default.
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