Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913008411> ?p ?o ?g. }
- W2913008411 endingPage "121" @default.
- W2913008411 startingPage "101" @default.
- W2913008411 abstract "Several plants display a wide range of beneficial properties, including antioxidant, anticholestatic, antinecrotic, antifibrotic and anticancer, that has been shown to be very useful for prevention and treatment of diverse liver illness, such as viral hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. The most studied plants/plant-derived compounds/extracts are Curcuma longa, Silybum marianum, quercetin, naringenin, coffee, Stevia rebaudiana, resveratrol, l-theanine, hesperidin, colchicine, Rosmarinus officinalis, and glycyrrhizin. Plant drugs (PDs) may exert antioxidant properties by scavenging free radicals and/or by inducing the activity of nuclear factor erythroid 2–related factor that induces the transcription of target antioxidant genes such as thioredoxin, glutathione reductase, ferritin, hem oxygenase-1, superoxide dismutase, catalase, thereby producing an antioxidative response. The antiinflammatory activity of PDs is associated with their ability to downregulate the nuclear factor kappa B that is a master proinflammatory factor responsible for the overexpression of noxious signaling molecules such as tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, and lipoxygenase. Moreover, PDs protect the liver from injury by antifibrotic mechanisms, reducing transforming growth factor-beta, the most important profibrogenic factor, and preventing the activation of the hepatic stellate cells, which are the responsible for the collagen fiber production. The anticancer properties are associated with the proapoptotic activity of PDs." @default.
- W2913008411 created "2019-02-21" @default.
- W2913008411 creator A5016087971 @default.
- W2913008411 creator A5032718913 @default.
- W2913008411 date "2019-01-01" @default.
- W2913008411 modified "2023-10-14" @default.
- W2913008411 title "Phytotherapy for the Liver" @default.
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