FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913012073> ?p ?o ?g. }

• W2913012073 endingPage "713" @default.
• W2913012073 startingPage "701" @default.
• W2913012073 abstract "Previous studies have shown that mitochondrial dysfunction plays an important role in high- glucose(HG)-induced podocyte injury and thus contributes to the progression of diabetic nephropathy(DN). The histone deacetylase Sirtuin6 (Sirt6) has been revealed to have an essential role in the regulation of mitochondrial function in skeletal muscle and cardiomyocytes. However, its specific role in mitochondrial homeostasis in podocytes is undetermined. Here, we aimeds to explore the physiological function of Sirt6 in podocyte mitochondria and apoptosis under HG conditions and explore the possible mechanism. Herein, we observed that Sirt6-WT-1 colocalization was suppressed in the glomeruli of patients with DN. In addition, diabetic mice exhibited reduced Sirt6 expression and AMP kinase (AMPK) dephosphorylation accompanied by mitochondrial morphological abnormalities. In vitro, podocytes exposed to HG presented with mitochondrial morphological alterations and podocyte apoptosis accompanied by Sirt6 and p-AMPK downregulation. In addition, HG promoted a decrease in mitochondrial number and an increase in mitochondrial superoxide production as well as a decreased mitochondrial membrane potential. ROS production was also increased in HG-treated podocytes. Conversely, all these mitochondrial defects induced by HG were significantly alleviated by Sirt6 plasmid transfection. Sirt6 overexpression simultaneously alleviated HG-induced podocyte apoptosis and oxidative stress, as well as increased AMPK phosphorylation. Increased levels of H3K9ac and H3K56ac induced by HG were attenuated in podocytes transfected with Sirt6 plasmids. Therefore, these results elucidated that Sirt6 protects mitochondria of podocytes and exerts anti-apoptotic effects via activating AMPK pathway. The present findings provide key insights into the pivotal role of mitochondria regulation by SIRT6 in its protective effects on podocytes." @default.
• W2913012073 created "2019-02-21" @default.
• W2913012073 creator A5012330169 @default.
• W2913012073 creator A5013359792 @default.
• W2913012073 creator A5023563380 @default.
• W2913012073 creator A5044757881 @default.
• W2913012073 creator A5045236201 @default.
• W2913012073 creator A5060648440 @default.
• W2913012073 creator A5085736815 @default.
• W2913012073 creator A5091135013 @default.
• W2913012073 date "2019-01-01" @default.
• W2913012073 modified "2023-10-18" @default.
• W2913012073 title "Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation" @default.
• W2913012073 cites W1523693806 @default.
• W2913012073 cites W1599948477 @default.
• W2913012073 cites W1897148373 @default.
• W2913012073 cites W1972924731 @default.
• W2913012073 cites W1979066252 @default.
• W2913012073 cites W1990909446 @default.
• W2913012073 cites W1994540097 @default.
• W2913012073 cites W2000870007 @default.
• W2913012073 cites W2002393930 @default.
• W2913012073 cites W2003291247 @default.
• W2913012073 cites W2009715420 @default.
• W2913012073 cites W2025668535 @default.
• W2913012073 cites W2049929178 @default.
• W2913012073 cites W2054866841 @default.
• W2913012073 cites W2055298026 @default.
• W2913012073 cites W2074393318 @default.
• W2913012073 cites W2076284407 @default.
• W2913012073 cites W2077645437 @default.
• W2913012073 cites W2079580613 @default.
• W2913012073 cites W2085574022 @default.
• W2913012073 cites W2088469132 @default.
• W2913012073 cites W2103018087 @default.
• W2913012073 cites W2103241681 @default.
• W2913012073 cites W2109560454 @default.
• W2913012073 cites W2110174113 @default.
• W2913012073 cites W2110928985 @default.
• W2913012073 cites W2122341467 @default.
• W2913012073 cites W2129632486 @default.
• W2913012073 cites W2133070989 @default.
• W2913012073 cites W2143049294 @default.
• W2913012073 cites W2167711201 @default.
• W2913012073 cites W2175806733 @default.
• W2913012073 cites W2177426766 @default.
• W2913012073 cites W2235539938 @default.
• W2913012073 cites W2407139222 @default.
• W2913012073 cites W2512845699 @default.
• W2913012073 cites W2552184863 @default.
• W2913012073 cites W2597939397 @default.
• W2913012073 cites W2741987789 @default.
• W2913012073 cites W2752265698 @default.
• W2913012073 cites W2793396330 @default.
• W2913012073 cites W2795990765 @default.
• W2913012073 cites W2585110537 @default.
• W2913012073 doi "https://doi.org/10.7150/ijbs.29323" @default.
• W2913012073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6367578" @default.
• W2913012073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30745856" @default.
• W2913012073 hasPublicationYear "2019" @default.
• W2913012073 type Work @default.
• W2913012073 sameAs 2913012073 @default.
• W2913012073 citedByCount "93" @default.
• W2913012073 countsByYear W29130120732019 @default.
• W2913012073 countsByYear W29130120732020 @default.
• W2913012073 countsByYear W29130120732021 @default.
• W2913012073 countsByYear W29130120732022 @default.
• W2913012073 countsByYear W29130120732023 @default.
• W2913012073 crossrefType "journal-article" @default.
• W2913012073 hasAuthorship W2913012073A5012330169 @default.
• W2913012073 hasAuthorship W2913012073A5013359792 @default.
• W2913012073 hasAuthorship W2913012073A5023563380 @default.
• W2913012073 hasAuthorship W2913012073A5044757881 @default.
• W2913012073 hasAuthorship W2913012073A5045236201 @default.
• W2913012073 hasAuthorship W2913012073A5060648440 @default.
• W2913012073 hasAuthorship W2913012073A5085736815 @default.
• W2913012073 hasAuthorship W2913012073A5091135013 @default.
• W2913012073 hasBestOaLocation W29130120731 @default.
• W2913012073 hasConcept C11960822 @default.
• W2913012073 hasConcept C126322002 @default.
• W2913012073 hasConcept C134018914 @default.
• W2913012073 hasConcept C185592680 @default.
• W2913012073 hasConcept C190283241 @default.
• W2913012073 hasConcept C2776151105 @default.
• W2913012073 hasConcept C2776780712 @default.
• W2913012073 hasConcept C2777146197 @default.
• W2913012073 hasConcept C2777229759 @default.
• W2913012073 hasConcept C2778175917 @default.
• W2913012073 hasConcept C2779561371 @default.
• W2913012073 hasConcept C2780091579 @default.
• W2913012073 hasConcept C2780124434 @default.
• W2913012073 hasConcept C28859421 @default.
• W2913012073 hasConcept C55493867 @default.
• W2913012073 hasConcept C71924100 @default.
• W2913012073 hasConcept C86803240 @default.
• W2913012073 hasConcept C95444343 @default.
• W2913012073 hasConcept C97029542 @default.
• W2913012073 hasConceptScore W2913012073C11960822 @default.

• next