Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913013685> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2913013685 endingPage "271" @default.
- W2913013685 startingPage "262" @default.
- W2913013685 abstract "Background: Ferula sumbul Hook. (Umbelliferae) roots have been traditionally used as sedative in nervous disorders. Objective: The present study identifies the components of essential oil of F. sumbul roots (EOFS) using GC-MS analysis and further evaluates mechanism-based anxiolytic potential of oil. Materials and Methods: EOFS was extracted using Clevenger apparatus, and was screened for anxiolytic activity using an elevated plus maze model. A battery of models was subsequently used to confirm the anxiolytic potential of EOFS. Further, benzodiazepine (BZD) receptor antagonist flumazenil and pentylenetetrazole (PTZ) were used for investigating the possible involvement of GABA receptors. Results: GC-MS analysis of EOFS revealed the presence of 32 components comprising triterpenoids and their derivatives. The oil exhibited significant anxiolytic activity at 50 μl/kg in various models like the elevated plus maze, light/dark, mirror chamber, open-field and mCPP-induced anxiety. The observation that anxiolytic effect of EOFS was completely blocked by benzodiazepine (BZD) receptor antagonist flumazenil, and partially by pentylenetetrazole, clearly demonstrates that anxiolytic activity of the oil is mediated mainly through BZD site on GABA receptors. Further, a significant reversal of mCPP induced anxiety by EOFS strongly indicates the possible involvement of 5-HT receptors in mediating anxiolytic activity of the oil. Conclusion: Results of the present study clearly demonstrates the anxiolytic potential of EOFS and, thus, validates the traditional relevance of the plant. This is the first report not only on multi-model based antianxiety activity of EOFS but also on the possible antianxiety mechanism of the oil." @default.
- W2913013685 created "2019-02-21" @default.
- W2913013685 creator A5023997097 @default.
- W2913013685 creator A5044284572 @default.
- W2913013685 creator A5084388631 @default.
- W2913013685 date "2020-06-16" @default.
- W2913013685 modified "2023-10-16" @default.
- W2913013685 title "GABA and 5-HT Receptor Mediated Anxiolytic Effect of Essential Oil of Ferula sumbul Hook. Roots" @default.
- W2913013685 cites W1510470483 @default.
- W2913013685 cites W1969887276 @default.
- W2913013685 cites W1984051490 @default.
- W2913013685 cites W1996897522 @default.
- W2913013685 cites W2008732658 @default.
- W2913013685 cites W2016699506 @default.
- W2913013685 cites W2032058764 @default.
- W2913013685 cites W2040801339 @default.
- W2913013685 cites W2041561931 @default.
- W2913013685 cites W2043251447 @default.
- W2913013685 cites W2049001079 @default.
- W2913013685 cites W2059335833 @default.
- W2913013685 cites W2071479225 @default.
- W2913013685 cites W2076602697 @default.
- W2913013685 cites W2083366148 @default.
- W2913013685 cites W2088133485 @default.
- W2913013685 cites W2089691937 @default.
- W2913013685 cites W2094063465 @default.
- W2913013685 cites W2098142293 @default.
- W2913013685 cites W2111912794 @default.
- W2913013685 cites W2127652169 @default.
- W2913013685 cites W2727882928 @default.
- W2913013685 cites W2774585439 @default.
- W2913013685 cites W2811289650 @default.
- W2913013685 cites W4297791741 @default.
- W2913013685 cites W925041399 @default.
- W2913013685 doi "https://doi.org/10.2174/2210315509666190211123646" @default.
- W2913013685 hasPublicationYear "2020" @default.
- W2913013685 type Work @default.
- W2913013685 sameAs 2913013685 @default.
- W2913013685 citedByCount "1" @default.
- W2913013685 countsByYear W29130136852021 @default.
- W2913013685 crossrefType "journal-article" @default.
- W2913013685 hasAuthorship W2913013685A5023997097 @default.
- W2913013685 hasAuthorship W2913013685A5044284572 @default.
- W2913013685 hasAuthorship W2913013685A5084388631 @default.
- W2913013685 hasConcept C118552586 @default.
- W2913013685 hasConcept C126322002 @default.
- W2913013685 hasConcept C15744967 @default.
- W2913013685 hasConcept C168258287 @default.
- W2913013685 hasConcept C170493617 @default.
- W2913013685 hasConcept C173586616 @default.
- W2913013685 hasConcept C185592680 @default.
- W2913013685 hasConcept C2776885963 @default.
- W2913013685 hasConcept C2777765862 @default.
- W2913013685 hasConcept C2778173252 @default.
- W2913013685 hasConcept C2778409475 @default.
- W2913013685 hasConcept C2779085643 @default.
- W2913013685 hasConcept C55493867 @default.
- W2913013685 hasConcept C558461103 @default.
- W2913013685 hasConcept C71924100 @default.
- W2913013685 hasConcept C98274493 @default.
- W2913013685 hasConceptScore W2913013685C118552586 @default.
- W2913013685 hasConceptScore W2913013685C126322002 @default.
- W2913013685 hasConceptScore W2913013685C15744967 @default.
- W2913013685 hasConceptScore W2913013685C168258287 @default.
- W2913013685 hasConceptScore W2913013685C170493617 @default.
- W2913013685 hasConceptScore W2913013685C173586616 @default.
- W2913013685 hasConceptScore W2913013685C185592680 @default.
- W2913013685 hasConceptScore W2913013685C2776885963 @default.
- W2913013685 hasConceptScore W2913013685C2777765862 @default.
- W2913013685 hasConceptScore W2913013685C2778173252 @default.
- W2913013685 hasConceptScore W2913013685C2778409475 @default.
- W2913013685 hasConceptScore W2913013685C2779085643 @default.
- W2913013685 hasConceptScore W2913013685C55493867 @default.
- W2913013685 hasConceptScore W2913013685C558461103 @default.
- W2913013685 hasConceptScore W2913013685C71924100 @default.
- W2913013685 hasConceptScore W2913013685C98274493 @default.
- W2913013685 hasFunder F4320320767 @default.
- W2913013685 hasIssue "3" @default.
- W2913013685 hasLocation W29130136851 @default.
- W2913013685 hasOpenAccess W2913013685 @default.
- W2913013685 hasPrimaryLocation W29130136851 @default.
- W2913013685 hasRelatedWork W2036863060 @default.
- W2913013685 hasRelatedWork W2038331423 @default.
- W2913013685 hasRelatedWork W2047039000 @default.
- W2913013685 hasRelatedWork W2083814207 @default.
- W2913013685 hasRelatedWork W2120990984 @default.
- W2913013685 hasRelatedWork W2181324467 @default.
- W2913013685 hasRelatedWork W2606368808 @default.
- W2913013685 hasRelatedWork W2808825382 @default.
- W2913013685 hasRelatedWork W2912774478 @default.
- W2913013685 hasRelatedWork W3145089502 @default.
- W2913013685 hasVolume "10" @default.
- W2913013685 isParatext "false" @default.
- W2913013685 isRetracted "false" @default.
- W2913013685 magId "2913013685" @default.
- W2913013685 workType "article" @default.