FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913016487> ?p ?o ?g. }

• W2913016487 abstract "Even though genome-wide association studies (GWASs) have identified dozens of single nucleotide polymorphisms (SNPs) affecting the susceptibility to lung cancer, only a tiny fraction of heritability can be explained. Regulating the expression of surrounding genes is one of the important mechanisms for SNPs to exert their effect. So it is necessary to systematically evaluate the associations between expression quantitative trait loci (eQTL) and lung cancer risk. In this study, a two-stage case-control design was used to evaluate the associations of eQTL SNPs (eSNPs) defined by GTEx in normal lung tissues with the risk of lung cancer based on two GWAS datasets, including 7127 cases and 6818 controls. Promising variants were replicated in an independent population with 1026 lung cancer cases and 1006 controls. Functional annotations of the identified eSNPs and related genes were performed based on multiple public databases. Finally, we identified two potential eSNPs associated with the risk of lung cancer in 3q28 [rs505974, OR = 0.90 (0.86 - 0.94), P = 6.51 × 10-6] and 21q22.3 [rs79589812, OR = 1.38 (1.21 - 1.58), P = 2.46 × 10-6]. Subgroup analysis showed rs505974 might interact with smoking behaviour. Gene-set enrichment and pathway analysis revealed that rs505974 may affect the susceptibility to lung cancer via regulating the expression of CLDN16, which may be involved in the chemical carcinogenesis pathway, whereas rs79589812 may regulate the expression of SPATC1L, which may be involved in the base excision repair pathway. These results provide an overview of the associations between eSNPs and lung cancer in Asian populations." @default.
• W2913016487 created "2019-02-21" @default.
• W2913016487 creator A5001720031 @default.
• W2913016487 creator A5004031758 @default.
• W2913016487 creator A5029093929 @default.
• W2913016487 creator A5032100785 @default.
• W2913016487 creator A5032349610 @default.
• W2913016487 creator A5036777238 @default.
• W2913016487 creator A5038619577 @default.
• W2913016487 creator A5041015608 @default.
• W2913016487 creator A5045493892 @default.
• W2913016487 creator A5055515538 @default.
• W2913016487 creator A5073435344 @default.
• W2913016487 creator A5084213516 @default.
• W2913016487 date "2019-01-23" @default.
• W2913016487 modified "2023-10-18" @default.
• W2913016487 title "Genome-wide analysis of expression quantitative trait loci identified potential lung cancer susceptibility variants among Asian populations" @default.
• W2913016487 cites W1980991473 @default.
• W2913016487 cites W1984068087 @default.
• W2913016487 cites W1985323804 @default.
• W2913016487 cites W1992436001 @default.
• W2913016487 cites W2002351570 @default.
• W2913016487 cites W2012379047 @default.
• W2913016487 cites W2018838463 @default.
• W2913016487 cites W2022051063 @default.
• W2913016487 cites W2049330354 @default.
• W2913016487 cites W2061539393 @default.
• W2913016487 cites W2070082005 @default.
• W2913016487 cites W2072881647 @default.
• W2913016487 cites W2078059415 @default.
• W2913016487 cites W2082058760 @default.
• W2913016487 cites W2089415609 @default.
• W2913016487 cites W2099085143 @default.
• W2913016487 cites W2116868464 @default.
• W2913016487 cites W2139216037 @default.
• W2913016487 cites W2151548650 @default.
• W2913016487 cites W2168945351 @default.
• W2913016487 cites W2175019761 @default.
• W2913016487 cites W2225530246 @default.
• W2913016487 cites W2248907500 @default.
• W2913016487 cites W2523964663 @default.
• W2913016487 cites W2598777425 @default.
• W2913016487 cites W2612427157 @default.
• W2913016487 cites W2745602859 @default.
• W2913016487 cites W2917837889 @default.
• W2913016487 cites W4292230194 @default.
• W2913016487 doi "https://doi.org/10.1093/carcin/bgy165" @default.
• W2913016487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30689816" @default.
• W2913016487 hasPublicationYear "2019" @default.
• W2913016487 type Work @default.
• W2913016487 sameAs 2913016487 @default.
• W2913016487 citedByCount "3" @default.
• W2913016487 countsByYear W29130164872019 @default.
• W2913016487 countsByYear W29130164872020 @default.
• W2913016487 countsByYear W29130164872021 @default.
• W2913016487 crossrefType "journal-article" @default.
• W2913016487 hasAuthorship W2913016487A5001720031 @default.
• W2913016487 hasAuthorship W2913016487A5004031758 @default.
• W2913016487 hasAuthorship W2913016487A5029093929 @default.
• W2913016487 hasAuthorship W2913016487A5032100785 @default.
• W2913016487 hasAuthorship W2913016487A5032349610 @default.
• W2913016487 hasAuthorship W2913016487A5036777238 @default.
• W2913016487 hasAuthorship W2913016487A5038619577 @default.
• W2913016487 hasAuthorship W2913016487A5041015608 @default.
• W2913016487 hasAuthorship W2913016487A5045493892 @default.
• W2913016487 hasAuthorship W2913016487A5055515538 @default.
• W2913016487 hasAuthorship W2913016487A5073435344 @default.
• W2913016487 hasAuthorship W2913016487A5084213516 @default.
• W2913016487 hasConcept C104317684 @default.
• W2913016487 hasConcept C106208931 @default.
• W2913016487 hasConcept C121608353 @default.
• W2913016487 hasConcept C135763542 @default.
• W2913016487 hasConcept C143998085 @default.
• W2913016487 hasConcept C153209595 @default.
• W2913016487 hasConcept C168393362 @default.
• W2913016487 hasConcept C186413461 @default.
• W2913016487 hasConcept C2776256026 @default.
• W2913016487 hasConcept C2779372377 @default.
• W2913016487 hasConcept C2908647359 @default.
• W2913016487 hasConcept C54355233 @default.
• W2913016487 hasConcept C555283112 @default.
• W2913016487 hasConcept C71924100 @default.
• W2913016487 hasConcept C81941488 @default.
• W2913016487 hasConcept C86803240 @default.
• W2913016487 hasConcept C99454951 @default.
• W2913016487 hasConceptScore W2913016487C104317684 @default.
• W2913016487 hasConceptScore W2913016487C106208931 @default.
• W2913016487 hasConceptScore W2913016487C121608353 @default.
• W2913016487 hasConceptScore W2913016487C135763542 @default.
• W2913016487 hasConceptScore W2913016487C143998085 @default.
• W2913016487 hasConceptScore W2913016487C153209595 @default.
• W2913016487 hasConceptScore W2913016487C168393362 @default.
• W2913016487 hasConceptScore W2913016487C186413461 @default.
• W2913016487 hasConceptScore W2913016487C2776256026 @default.
• W2913016487 hasConceptScore W2913016487C2779372377 @default.
• W2913016487 hasConceptScore W2913016487C2908647359 @default.
• W2913016487 hasConceptScore W2913016487C54355233 @default.
• W2913016487 hasConceptScore W2913016487C555283112 @default.
• W2913016487 hasConceptScore W2913016487C71924100 @default.
• W2913016487 hasConceptScore W2913016487C81941488 @default.

• next