FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913016612> ?p ?o ?g. }

• W2913016612 abstract "Candida species, such as Candida albicans and Candida glabrata, cause infections at different host sites because they adapt their metabolism depending on the available nutrients. They are able to proliferate under both nutrient-rich and nutrient-poor conditions. This adaptation is what makes these fungi successful pathogens. For both species, sugars are very important nutrients and as the sugar level differs depending on the host niche, different sugar sensing systems must be present. Saccharomyces cerevisiae has been used as a model for the identification of these sugar sensing systems. One of the main carbon sources for yeast is glucose, for which three different pathways have been described. First, two transporter-like proteins, ScSnf3 and ScRgt2 sense glucose levels resulting in the induction of different hexose transporter genes. This situation is comparable in C. albicans and C. glabrata, where sensing of glucose by CaHgt4 and CgSnf3 respectively, also results in hexose transporter gene induction. The second glucose sensing mechanism in S. cerevisiae is via the G-protein coupled receptor ScGpr1, which causes the activation of the cAMP/PKA pathway, resulting in rapid adaptation to the presence of glucose. The main components of this glucose sensing system are also conserved in C. albicans and C. glabrata. However, it seems that the ligand(s) for CaGpr1 are not sugars but lactate and methionine. In C. glabrata, this pathway has not yet been investigated. Finally, the glucose repression pathway ensures repression of respiration and repression of the use of alternative carbon sources. This pathway is not well characterized in Candida species. It is important to note that, apart from glucose, other sugars and sugar-analogs, such as N-acetylglucosamine in the case of C. albicans, are also important carbon sources. In these fungal pathogens, sensing sugars is important for a number of virulence attributes, including adhesion, oxidative stress resistance, biofilm formation, morphogenesis, invasion and antifungal drug tolerance. In this review, the sugar sensing and signaling mechanisms in these Candida species are compared to S. cerevisiae." @default.
• W2913016612 created "2019-02-21" @default.
• W2913016612 creator A5019957076 @default.
• W2913016612 creator A5054731960 @default.
• W2913016612 creator A5090068893 @default.
• W2913016612 date "2019-01-30" @default.
• W2913016612 modified "2023-10-18" @default.
• W2913016612 title "Sugar Sensing and Signaling in Candida albicans and Candida glabrata" @default.
• W2913016612 cites W1599609091 @default.
• W2913016612 cites W1763161027 @default.
• W2913016612 cites W1776443552 @default.
• W2913016612 cites W1817988031 @default.
• W2913016612 cites W1837413175 @default.
• W2913016612 cites W187623135 @default.
• W2913016612 cites W1888620137 @default.
• W2913016612 cites W1959595138 @default.
• W2913016612 cites W1967344134 @default.
• W2913016612 cites W1968221002 @default.
• W2913016612 cites W1970770294 @default.
• W2913016612 cites W1974037811 @default.
• W2913016612 cites W1974912254 @default.
• W2913016612 cites W1975985109 @default.
• W2913016612 cites W1981945680 @default.
• W2913016612 cites W1982872534 @default.
• W2913016612 cites W1983730914 @default.
• W2913016612 cites W1983778018 @default.
• W2913016612 cites W1987087859 @default.
• W2913016612 cites W1987704534 @default.
• W2913016612 cites W1988608160 @default.
• W2913016612 cites W1993775249 @default.
• W2913016612 cites W1993845396 @default.
• W2913016612 cites W1994473731 @default.
• W2913016612 cites W1995754833 @default.
• W2913016612 cites W1996119276 @default.
• W2913016612 cites W1996326847 @default.
• W2913016612 cites W2000045912 @default.
• W2913016612 cites W2000047924 @default.
• W2913016612 cites W2002853127 @default.
• W2913016612 cites W2008014792 @default.
• W2913016612 cites W2008141632 @default.
• W2913016612 cites W2012665233 @default.
• W2913016612 cites W2014335767 @default.
• W2913016612 cites W2015354811 @default.
• W2913016612 cites W2018666541 @default.
• W2913016612 cites W2025526564 @default.
• W2913016612 cites W2025595506 @default.
• W2913016612 cites W2028403255 @default.
• W2913016612 cites W2035287841 @default.
• W2913016612 cites W2036686552 @default.
• W2913016612 cites W2036699947 @default.
• W2913016612 cites W2039623126 @default.
• W2913016612 cites W2042161296 @default.
• W2913016612 cites W2043177548 @default.
• W2913016612 cites W2044898452 @default.
• W2913016612 cites W2047373064 @default.
• W2913016612 cites W2050808844 @default.
• W2913016612 cites W2052579446 @default.
• W2913016612 cites W2053909542 @default.
• W2913016612 cites W2058459698 @default.
• W2913016612 cites W2060052352 @default.
• W2913016612 cites W2065761990 @default.
• W2913016612 cites W2067475510 @default.
• W2913016612 cites W2068139519 @default.
• W2913016612 cites W2069172362 @default.
• W2913016612 cites W2071982564 @default.
• W2913016612 cites W2076814714 @default.
• W2913016612 cites W2079036480 @default.
• W2913016612 cites W2079390987 @default.
• W2913016612 cites W2081288859 @default.
• W2913016612 cites W2081964136 @default.
• W2913016612 cites W2082917494 @default.
• W2913016612 cites W2088256607 @default.
• W2913016612 cites W2088977070 @default.
• W2913016612 cites W2091567823 @default.
• W2913016612 cites W2091670176 @default.
• W2913016612 cites W2093315295 @default.
• W2913016612 cites W2095035085 @default.
• W2913016612 cites W2098977307 @default.
• W2913016612 cites W2099564486 @default.
• W2913016612 cites W2100969531 @default.
• W2913016612 cites W2105087827 @default.
• W2913016612 cites W2105103077 @default.
• W2913016612 cites W2105740329 @default.
• W2913016612 cites W2106388474 @default.
• W2913016612 cites W2110686257 @default.
• W2913016612 cites W2110874942 @default.
• W2913016612 cites W2113627544 @default.
• W2913016612 cites W2113679644 @default.
• W2913016612 cites W2114510542 @default.
• W2913016612 cites W2117260150 @default.
• W2913016612 cites W2117697356 @default.
• W2913016612 cites W2118956583 @default.
• W2913016612 cites W2121322589 @default.
• W2913016612 cites W2122366486 @default.
• W2913016612 cites W2123240988 @default.
• W2913016612 cites W2124750674 @default.
• W2913016612 cites W2125579189 @default.
• W2913016612 cites W2125848302 @default.
• W2913016612 cites W2127142654 @default.
• W2913016612 cites W2131942193 @default.

• next