Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913017330> ?p ?o ?g. }
- W2913017330 endingPage "3589" @default.
- W2913017330 startingPage "3582" @default.
- W2913017330 abstract "A biomimetic nanochannel-ionchannel hybrid coupled with electrochemical detector was developed for label-free and ultrasensitive detection of microRNA (miRNA) in cells. Probe single stranded DNA (ssDNA) was first immobilized on the outer surface of the nanochannel-ionchannel hybrid membrane, which can hybridize with the target miRNA in cells. Due to the unique mass transfer property of the hybrid, the DNA-miRNA hybridization kinetics can be sensitively monitored in real-time using the electrochemical technique. More importantly, due to the super small size of the ionchannels, the DNA probe immobilization and hybridization process can be carried out on the outer surface of the ionchannel side, which can effectively avoid the blockage and damage of channels and thus considerably enhance the reproducibility and accuracy of the method. Using this strategy, the miRNA ranging from 0.1 fM to 0.1 μM can be facilely detected with a low detection limit of 15.4 aM, which is much lower than most reported work. The present strategy provides a sensitive and label-free miRNA detection platform, which will be of great significance in biomedical research and clinical diagnosis." @default.
- W2913017330 created "2019-02-21" @default.
- W2913017330 creator A5040914101 @default.
- W2913017330 creator A5055547866 @default.
- W2913017330 creator A5056849013 @default.
- W2913017330 creator A5060685174 @default.
- W2913017330 creator A5079713143 @default.
- W2913017330 creator A5087402925 @default.
- W2913017330 date "2019-02-13" @default.
- W2913017330 modified "2023-10-14" @default.
- W2913017330 title "Biomimetic Nanochannel-Ionchannel Hybrid for Ultrasensitive and Label-Free Detection of MicroRNA in Cells" @default.
- W2913017330 cites W1672385484 @default.
- W2913017330 cites W1982885353 @default.
- W2913017330 cites W2002995168 @default.
- W2913017330 cites W2007989168 @default.
- W2913017330 cites W2014509607 @default.
- W2913017330 cites W2020584524 @default.
- W2913017330 cites W2024582780 @default.
- W2913017330 cites W2054972712 @default.
- W2913017330 cites W2076947357 @default.
- W2913017330 cites W2084911598 @default.
- W2913017330 cites W2095177911 @default.
- W2913017330 cites W2095765891 @default.
- W2913017330 cites W2100653695 @default.
- W2913017330 cites W2134398337 @default.
- W2913017330 cites W2203881472 @default.
- W2913017330 cites W2223495155 @default.
- W2913017330 cites W2315423122 @default.
- W2913017330 cites W2327375162 @default.
- W2913017330 cites W2331405762 @default.
- W2913017330 cites W2396235139 @default.
- W2913017330 cites W2423792827 @default.
- W2913017330 cites W2469219481 @default.
- W2913017330 cites W2531410217 @default.
- W2913017330 cites W2580095184 @default.
- W2913017330 cites W2605766279 @default.
- W2913017330 cites W2618853121 @default.
- W2913017330 cites W2729686289 @default.
- W2913017330 cites W2729817719 @default.
- W2913017330 cites W2733423555 @default.
- W2913017330 cites W2737886736 @default.
- W2913017330 cites W2748780887 @default.
- W2913017330 cites W2750939010 @default.
- W2913017330 cites W2754413041 @default.
- W2913017330 cites W2763238899 @default.
- W2913017330 cites W2770055706 @default.
- W2913017330 cites W2770168270 @default.
- W2913017330 cites W2785329326 @default.
- W2913017330 cites W2785593452 @default.
- W2913017330 cites W2789332244 @default.
- W2913017330 cites W2792331018 @default.
- W2913017330 cites W2795381674 @default.
- W2913017330 cites W2799751269 @default.
- W2913017330 cites W2806802922 @default.
- W2913017330 cites W2886246069 @default.
- W2913017330 cites W2888126592 @default.
- W2913017330 cites W2889044695 @default.
- W2913017330 cites W2889872375 @default.
- W2913017330 cites W2898118082 @default.
- W2913017330 cites W2904737084 @default.
- W2913017330 cites W4252906629 @default.
- W2913017330 doi "https://doi.org/10.1021/acs.analchem.8b05536" @default.
- W2913017330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30758184" @default.
- W2913017330 hasPublicationYear "2019" @default.
- W2913017330 type Work @default.
- W2913017330 sameAs 2913017330 @default.
- W2913017330 citedByCount "63" @default.
- W2913017330 countsByYear W29130173302019 @default.
- W2913017330 countsByYear W29130173302020 @default.
- W2913017330 countsByYear W29130173302021 @default.
- W2913017330 countsByYear W29130173302022 @default.
- W2913017330 countsByYear W29130173302023 @default.
- W2913017330 crossrefType "journal-article" @default.
- W2913017330 hasAuthorship W2913017330A5040914101 @default.
- W2913017330 hasAuthorship W2913017330A5055547866 @default.
- W2913017330 hasAuthorship W2913017330A5056849013 @default.
- W2913017330 hasAuthorship W2913017330A5060685174 @default.
- W2913017330 hasAuthorship W2913017330A5079713143 @default.
- W2913017330 hasAuthorship W2913017330A5087402925 @default.
- W2913017330 hasConcept C104317684 @default.
- W2913017330 hasConcept C119128265 @default.
- W2913017330 hasConcept C12554922 @default.
- W2913017330 hasConcept C130197536 @default.
- W2913017330 hasConcept C145059251 @default.
- W2913017330 hasConcept C171250308 @default.
- W2913017330 hasConcept C185592680 @default.
- W2913017330 hasConcept C192562407 @default.
- W2913017330 hasConcept C41625074 @default.
- W2913017330 hasConcept C43617362 @default.
- W2913017330 hasConcept C552990157 @default.
- W2913017330 hasConcept C55493867 @default.
- W2913017330 hasConcept C86803240 @default.
- W2913017330 hasConceptScore W2913017330C104317684 @default.
- W2913017330 hasConceptScore W2913017330C119128265 @default.
- W2913017330 hasConceptScore W2913017330C12554922 @default.
- W2913017330 hasConceptScore W2913017330C130197536 @default.
- W2913017330 hasConceptScore W2913017330C145059251 @default.
- W2913017330 hasConceptScore W2913017330C171250308 @default.