Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913019594> ?p ?o ?g. }
- W2913019594 endingPage "759" @default.
- W2913019594 startingPage "755" @default.
- W2913019594 abstract "Methanol is a common solubilizing agent used to study transmembrane proteins/peptides in biological and synthetic membranes. Using small angle neutron scattering and a strategic contrast-matching scheme, we show that methanol has a major impact on lipid dynamics. Under increasing methanol concentrations, isotopically distinct 1,2-dimyristoyl-sn-glycero-3-phosphocholine large unilamellar vesicle populations exhibit increased mixing. Specifically, 1,2-dimyristoyl-sn-glycero-3-phosphocholine transfer and flip-flop kinetics display linear and exponential rate enhancements, respectively. Ultimately, methanol is capable of influencing the structure-function relationship associated with bilayer composition (e.g., lipid asymmetry). The use of methanol as a carrier solvent, despite better simulating some biological conditions (e.g., antimicrobial attack), can help misconstrue lipid scrambling as the action of proteins or peptides, when in actuality it is a combination of solvent and biological agent. As bilayer compositional stability is crucial to cell survival and protein reconstitution, these results highlight the importance of methanol, and solvents in general, in biomembrane and proteolipid studies." @default.
- W2913019594 created "2019-02-21" @default.
- W2913019594 creator A5021413589 @default.
- W2913019594 creator A5024708714 @default.
- W2913019594 creator A5044002992 @default.
- W2913019594 creator A5051233936 @default.
- W2913019594 creator A5055271071 @default.
- W2913019594 creator A5089102862 @default.
- W2913019594 date "2019-03-01" @default.
- W2913019594 modified "2023-09-30" @default.
- W2913019594 title "Methanol Accelerates DMPC Flip-Flop and Transfer: A SANS Study on Lipid Dynamics" @default.
- W2913019594 cites W1544573343 @default.
- W2913019594 cites W1674581539 @default.
- W2913019594 cites W1940692702 @default.
- W2913019594 cites W1966330055 @default.
- W2913019594 cites W1973823143 @default.
- W2913019594 cites W1975386547 @default.
- W2913019594 cites W1976081665 @default.
- W2913019594 cites W1981010770 @default.
- W2913019594 cites W1981020955 @default.
- W2913019594 cites W1990627676 @default.
- W2913019594 cites W2001754145 @default.
- W2913019594 cites W2012432781 @default.
- W2913019594 cites W2029513462 @default.
- W2913019594 cites W2032284161 @default.
- W2913019594 cites W2034812849 @default.
- W2913019594 cites W2039384938 @default.
- W2913019594 cites W2046059789 @default.
- W2913019594 cites W2055188636 @default.
- W2913019594 cites W2057653477 @default.
- W2913019594 cites W2064630836 @default.
- W2913019594 cites W2066901482 @default.
- W2913019594 cites W2078344803 @default.
- W2913019594 cites W2080489010 @default.
- W2913019594 cites W2083013159 @default.
- W2913019594 cites W2088246177 @default.
- W2913019594 cites W2090571818 @default.
- W2913019594 cites W2125872855 @default.
- W2913019594 cites W2139887680 @default.
- W2913019594 cites W2152335329 @default.
- W2913019594 cites W2154973684 @default.
- W2913019594 cites W2156835500 @default.
- W2913019594 cites W2164361934 @default.
- W2913019594 cites W2271112592 @default.
- W2913019594 cites W2313889988 @default.
- W2913019594 cites W2316541482 @default.
- W2913019594 cites W2323289371 @default.
- W2913019594 cites W2576992275 @default.
- W2913019594 cites W2593008007 @default.
- W2913019594 cites W2595722516 @default.
- W2913019594 cites W2630654643 @default.
- W2913019594 cites W2882141451 @default.
- W2913019594 cites W4210958643 @default.
- W2913019594 cites W643494320 @default.
- W2913019594 doi "https://doi.org/10.1016/j.bpj.2019.01.021" @default.
- W2913019594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400822" @default.
- W2913019594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30777306" @default.
- W2913019594 hasPublicationYear "2019" @default.
- W2913019594 type Work @default.
- W2913019594 sameAs 2913019594 @default.
- W2913019594 citedByCount "23" @default.
- W2913019594 countsByYear W29130195942012 @default.
- W2913019594 countsByYear W29130195942019 @default.
- W2913019594 countsByYear W29130195942020 @default.
- W2913019594 countsByYear W29130195942021 @default.
- W2913019594 countsByYear W29130195942022 @default.
- W2913019594 countsByYear W29130195942023 @default.
- W2913019594 crossrefType "journal-article" @default.
- W2913019594 hasAuthorship W2913019594A5021413589 @default.
- W2913019594 hasAuthorship W2913019594A5024708714 @default.
- W2913019594 hasAuthorship W2913019594A5044002992 @default.
- W2913019594 hasAuthorship W2913019594A5051233936 @default.
- W2913019594 hasAuthorship W2913019594A5055271071 @default.
- W2913019594 hasAuthorship W2913019594A5089102862 @default.
- W2913019594 hasBestOaLocation W29130195941 @default.
- W2913019594 hasConcept C118892022 @default.
- W2913019594 hasConcept C121332964 @default.
- W2913019594 hasConcept C125501631 @default.
- W2913019594 hasConcept C12554922 @default.
- W2913019594 hasConcept C130316041 @default.
- W2913019594 hasConcept C14631669 @default.
- W2913019594 hasConcept C148898269 @default.
- W2913019594 hasConcept C155672457 @default.
- W2913019594 hasConcept C170493617 @default.
- W2913019594 hasConcept C171250308 @default.
- W2913019594 hasConcept C178790620 @default.
- W2913019594 hasConcept C185592680 @default.
- W2913019594 hasConcept C192157962 @default.
- W2913019594 hasConcept C192562407 @default.
- W2913019594 hasConcept C24530287 @default.
- W2913019594 hasConcept C2779607525 @default.
- W2913019594 hasConcept C2780471494 @default.
- W2913019594 hasConcept C39944091 @default.
- W2913019594 hasConcept C41625074 @default.
- W2913019594 hasConcept C55493867 @default.
- W2913019594 hasConcept C62520636 @default.
- W2913019594 hasConcept C8010536 @default.
- W2913019594 hasConcept C86803240 @default.