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- W2913019807 abstract "Transcranial direct current brain stimulation (tDCS) has recently emerged as a novel noninvasive alternative for treating food addiction via modulating cortical excitability. Unfortunately, the action mechanism of tDCS has not been precisely defined as complex neurochemical pathways are involved in its molecular effects, and of particular interest are those related to its relation with energy metabolism in the brain. Recently, it was proposed that tDCS may be associated with increased permeability for ions as well as small and large molecules, thus suggesting the interplay between elemental and molecular changes. Although, there exists a plethora of analytical tools to study various aspects of the response to tDCS, there is still a need for a non-destructive in-situ biochemical microprobe which can fingerprint and quantify complex neurochemical pathways with the resolution reaching down to the single cell level. For the purpose of unraveling the biochemical response to tDCS in appetite control, we have recently proposed multi-molecular and multi-elemental contrast microscopy using thin, freeze-dried, unstained rat brain tissue sections. For the former, Fourier transfer infrared spectroscopy imaging with the focal plane array detector (FTIR-FPA) was demonstrated to yield distribution maps of a variety of molecular components such as lipids, proteins and carbohydrates at the single-cell resolution down to 2.6 μm. In turn, by using synchrotron hard (SRXRF) and low energy X-ray fluorescence (LEXRF) micro-spectrometry, we could track topographic distribution changes of a variety of chemical elements, ranging from carbon to zinc, with the spatial resolution ranging from 50 μm down to 0.5 μm. With this approach, we could demonstrate that the changes in feeding behavior, upon repeated frontal cortex tDCS, co-existed with altered lipid saturation alongside the deregulated levels of Na, Cl, Fe and Cu in various brain areas (i.e. the hunger and satiety centers) of the rat on a high calorie diet." @default.
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- W2913019807 date "2019-03-01" @default.
- W2913019807 modified "2023-09-30" @default.
- W2913019807 title "Molecular and elemental contrast microscopy for biochemical fingerprinting of the cellular action mechanisms underlying tDCS in appetite control" @default.
- W2913019807 doi "https://doi.org/10.1016/j.brs.2018.12.409" @default.
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