Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913046536> ?p ?o ?g. }
- W2913046536 abstract "Glioma are the most common type of malignant brain tumor, with glioblastoma (GBM) representing the most common and most lethal type of glioma. Surgical resection followed by radiotherapy and chemotherapy using the alkylating agent Temozolomide (TMZ) remain the mainstay of treatment for glioma. While this multimodal regimen is sufficient to temporarily eliminate the bulk of the tumor mass, recurrence is inevitable and often poses major challenges for clinical management due to treatment resistance and failure to respond to targeted therapies. Improved tumor profiling capacity has enabled characterization of the genomic landscape of gliomas with the overarching goal to identify clinically relevant subtypes and inform treatment decisions. Increased tumor mutational load has been shown to correlate with higher levels of neoantigens and is indicative of the potential to induce a durable response to immunotherapy. Following treatment with TMZ, a subset of glioma has been identified to recur with increased tumor mutational load. These hypermutant recurrent glioma represent a subtype of recurrence with unique molecular vulnerabilities. In this review, we will elaborate on the current knowledge regarding the evolution of hypermutation in gliomas and the potential therapeutic opportunities that arise with TMZ-induced hypermutation in gliomas." @default.
- W2913046536 created "2019-02-21" @default.
- W2913046536 creator A5005009665 @default.
- W2913046536 creator A5013101371 @default.
- W2913046536 creator A5024700033 @default.
- W2913046536 creator A5033748917 @default.
- W2913046536 creator A5052061134 @default.
- W2913046536 creator A5058602543 @default.
- W2913046536 creator A5059833313 @default.
- W2913046536 date "2019-02-04" @default.
- W2913046536 modified "2023-10-01" @default.
- W2913046536 title "Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities" @default.
- W2913046536 cites W111616551 @default.
- W2913046536 cites W1588685142 @default.
- W2913046536 cites W1882634342 @default.
- W2913046536 cites W1974254625 @default.
- W2913046536 cites W1975104842 @default.
- W2913046536 cites W1993762420 @default.
- W2913046536 cites W2021281024 @default.
- W2913046536 cites W2030017878 @default.
- W2913046536 cites W2040458067 @default.
- W2913046536 cites W2058810781 @default.
- W2913046536 cites W2065628422 @default.
- W2913046536 cites W2069580948 @default.
- W2913046536 cites W2071191831 @default.
- W2913046536 cites W2078510083 @default.
- W2913046536 cites W2089482729 @default.
- W2913046536 cites W2096287682 @default.
- W2913046536 cites W2097111597 @default.
- W2913046536 cites W2105528101 @default.
- W2913046536 cites W2109816625 @default.
- W2913046536 cites W2115276344 @default.
- W2913046536 cites W2123151929 @default.
- W2913046536 cites W2126817554 @default.
- W2913046536 cites W2127566231 @default.
- W2913046536 cites W2143095128 @default.
- W2913046536 cites W2148977460 @default.
- W2913046536 cites W2158480540 @default.
- W2913046536 cites W2159888487 @default.
- W2913046536 cites W2160420202 @default.
- W2913046536 cites W2161289668 @default.
- W2913046536 cites W2165425627 @default.
- W2913046536 cites W2167650288 @default.
- W2913046536 cites W2167960944 @default.
- W2913046536 cites W2303158491 @default.
- W2913046536 cites W2328946792 @default.
- W2913046536 cites W2366536035 @default.
- W2913046536 cites W2410468716 @default.
- W2913046536 cites W2436534309 @default.
- W2913046536 cites W245500602 @default.
- W2913046536 cites W2524525752 @default.
- W2913046536 cites W2527734859 @default.
- W2913046536 cites W2599571252 @default.
- W2913046536 cites W2600281432 @default.
- W2913046536 cites W2617489830 @default.
- W2913046536 cites W2739747835 @default.
- W2913046536 cites W2743266319 @default.
- W2913046536 cites W2779221466 @default.
- W2913046536 cites W2794129555 @default.
- W2913046536 cites W2886119834 @default.
- W2913046536 cites W2890729459 @default.
- W2913046536 cites W2896026978 @default.
- W2913046536 cites W2896599301 @default.
- W2913046536 cites W2902409020 @default.
- W2913046536 cites W2951880440 @default.
- W2913046536 doi "https://doi.org/10.3389/fonc.2019.00041" @default.
- W2913046536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369148" @default.
- W2913046536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30778375" @default.
- W2913046536 hasPublicationYear "2019" @default.
- W2913046536 type Work @default.
- W2913046536 sameAs 2913046536 @default.
- W2913046536 citedByCount "104" @default.
- W2913046536 countsByYear W29130465362019 @default.
- W2913046536 countsByYear W29130465362020 @default.
- W2913046536 countsByYear W29130465362021 @default.
- W2913046536 countsByYear W29130465362022 @default.
- W2913046536 countsByYear W29130465362023 @default.
- W2913046536 crossrefType "journal-article" @default.
- W2913046536 hasAuthorship W2913046536A5005009665 @default.
- W2913046536 hasAuthorship W2913046536A5013101371 @default.
- W2913046536 hasAuthorship W2913046536A5024700033 @default.
- W2913046536 hasAuthorship W2913046536A5033748917 @default.
- W2913046536 hasAuthorship W2913046536A5052061134 @default.
- W2913046536 hasAuthorship W2913046536A5058602543 @default.
- W2913046536 hasAuthorship W2913046536A5059833313 @default.
- W2913046536 hasBestOaLocation W29130465361 @default.
- W2913046536 hasConcept C126322002 @default.
- W2913046536 hasConcept C128526571 @default.
- W2913046536 hasConcept C143998085 @default.
- W2913046536 hasConcept C159654299 @default.
- W2913046536 hasConcept C203014093 @default.
- W2913046536 hasConcept C2776194525 @default.
- W2913046536 hasConcept C2777389519 @default.
- W2913046536 hasConcept C2777701055 @default.
- W2913046536 hasConcept C2778227246 @default.
- W2913046536 hasConcept C2778453870 @default.
- W2913046536 hasConcept C502942594 @default.
- W2913046536 hasConcept C509974204 @default.
- W2913046536 hasConcept C60644358 @default.
- W2913046536 hasConcept C71924100 @default.