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• W2913071400 startingPage "613" @default.
• W2913071400 abstract "Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. Cardiovascular disease is the main cause of death in these patients. There is no Food and Drug Association-approved medication for NAFLD patients. We aimed to provide more robust evidence on the use of medications that are inexpensive and available, namely, metformin, silymarin, pioglitazone, and vitamin E, for treating NAFLD.We conducted a randomized double-blinded, placebo-controlled trial on 150 consecutive patients with NAFLD who were assigned to five groups: lifestyle plus placebo, metformin 500 mg/day, silymarin 140 mg/day, pioglithasone 15 mg/day, and vitamin E 400 IU/day, all for 3 months. Anthropometric and biochemical variables were measured at baseline and 3 months later.The mean age of the patients was 47.0±9.1 (range: 18-65) years and the sex distribution was 73 (48.7%) women and 77 (51.3%) men. Patients in all groups showed a significant improvement in anthropometric parameters such as waist circumference and BMI. There was no statistically significant difference in alanine transaminase and aspartate transaminase in the control group after treatment (P=0.51, 0.18, respectively); however, both liver enzymes decreased significantly in the other groups.This randomized double-blinded placebo-controlled clinical trial suggested a significant benefit of silymarin, pioglitazone, and vitamin E in improving liver aminotransferases in patients with NAFLD after only 3 months, without exerting any specific side effects." @default.
• W2913071400 created "2019-02-21" @default.
• W2913071400 creator A5018728704 @default.
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• W2913071400 date "2019-05-01" @default.
• W2913071400 modified "2023-09-29" @default.
• W2913071400 title "Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial" @default.
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• W2913071400 doi "https://doi.org/10.1097/meg.0000000000001369" @default.
• W2913071400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30920975" @default.
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