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- W2913085055 abstract "Significance Genomically humanized animals overcoming species differences are invaluable for biomedical research. Although rats would be preferred over mice for several applications, generation of a humanized model is restricted to mice due to the difficulty of complex genetic manipulations in rats. In this study, we successfully generated humanized rats with megabase-sized gene clusters via combination of chromosome transfer using mouse artificial chromosome vector and genome editing technologies. In the humanized UGT2 and CYP3A transchromosomic rats described in this paper, the expression of the human genes, as well as the pharmacokinetics and metabolism of relevant probe substrates, accurately mimic the situation in humans. Thus, the advanced technologies can be used to generate fully humanized rats useful for biomedical research." @default.
- W2913085055 created "2019-02-21" @default.
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- W2913085055 date "2019-02-04" @default.
- W2913085055 modified "2023-10-16" @default.
- W2913085055 title "Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism" @default.
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- W2913085055 doi "https://doi.org/10.1073/pnas.1808255116" @default.
- W2913085055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386724" @default.
- W2913085055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30718425" @default.
- W2913085055 hasPublicationYear "2019" @default.