Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913108622> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2913108622 endingPage "288" @default.
- W2913108622 startingPage "280" @default.
- W2913108622 abstract "The present study aimed to investigate the potential inhibitory effects of 21 clinically available hypnotics on acetylcholine (ACh)-induced contractions in rat urinary bladder smooth muscle (UBSM) in order to predict whether these hypnotics could induce voiding impairment. ACh-induced contraction in rat UBSM was inhibited only by diphenhydramine (a histamine H1 receptor antagonist) at a concentration that was clinically relevant. ACh-induced contraction was also significantly inhibited by flurazepam (a benzodiazepine hypnotic) and suvorexant (an orexin receptor antagonist), albeit at concentrations that substantially exceeded clinically achievable blood levels. These three drugs (at 10−5 M) also inhibited high-KCl (80 mM) Locke–Ringer solution-induced contractions. In contrast to the effects of the abovementioned hypnotics, ACh-induced contractions were not significantly affected by triazolam, etizolam, brotizolam, lormetazepam, estazolam, flunitrazepam, nitrazepam (benzodiazepine hypnotics), thiopental, thiamylal, pentobarbital, amobarbital, secobarbital, phenobarbital (barbiturate hypnotics), zolpidem (an imidazopyridine hypnotic), zopiclone (a cyclopyrrolone hypnotic), ramelteon (a melatonin receptor agonist), bromovalerylurea, and chloral hydrate. These findings suggest that most clinically used hypnotics are not likely to result in anticholinergic-induced dysuria within their clinically achievable blood concentration ranges. Diphenhydramine may, however, induce voiding impairment, an action attributable to diminished UBSM contractility within its clinical dose range." @default.
- W2913108622 created "2019-02-21" @default.
- W2913108622 creator A5020377152 @default.
- W2913108622 creator A5020432791 @default.
- W2913108622 creator A5033277929 @default.
- W2913108622 creator A5043326702 @default.
- W2913108622 creator A5044587643 @default.
- W2913108622 creator A5049769324 @default.
- W2913108622 creator A5049772063 @default.
- W2913108622 creator A5077679585 @default.
- W2913108622 date "2019-02-01" @default.
- W2913108622 modified "2023-10-05" @default.
- W2913108622 title "Assessment of Inhibitory Effects of Hypnotics on Acetylcholine-Induced Contractions in Isolated Rat Urinary Bladder Smooth Muscle" @default.
- W2913108622 cites W2008227100 @default.
- W2913108622 cites W2025362034 @default.
- W2913108622 cites W2043083218 @default.
- W2913108622 cites W2057971042 @default.
- W2913108622 cites W2076465614 @default.
- W2913108622 cites W2094616210 @default.
- W2913108622 cites W2102416153 @default.
- W2913108622 cites W2116289594 @default.
- W2913108622 cites W2146284752 @default.
- W2913108622 cites W2221723423 @default.
- W2913108622 cites W2332074126 @default.
- W2913108622 cites W2610225473 @default.
- W2913108622 doi "https://doi.org/10.1248/bpb.b18-00829" @default.
- W2913108622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30713259" @default.
- W2913108622 hasPublicationYear "2019" @default.
- W2913108622 type Work @default.
- W2913108622 sameAs 2913108622 @default.
- W2913108622 citedByCount "4" @default.
- W2913108622 countsByYear W29131086222019 @default.
- W2913108622 countsByYear W29131086222021 @default.
- W2913108622 countsByYear W29131086222023 @default.
- W2913108622 crossrefType "journal-article" @default.
- W2913108622 hasAuthorship W2913108622A5020377152 @default.
- W2913108622 hasAuthorship W2913108622A5020432791 @default.
- W2913108622 hasAuthorship W2913108622A5033277929 @default.
- W2913108622 hasAuthorship W2913108622A5043326702 @default.
- W2913108622 hasAuthorship W2913108622A5044587643 @default.
- W2913108622 hasAuthorship W2913108622A5049769324 @default.
- W2913108622 hasAuthorship W2913108622A5049772063 @default.
- W2913108622 hasAuthorship W2913108622A5077679585 @default.
- W2913108622 hasBestOaLocation W29131086221 @default.
- W2913108622 hasConcept C126322002 @default.
- W2913108622 hasConcept C134018914 @default.
- W2913108622 hasConcept C170493617 @default.
- W2913108622 hasConcept C185592680 @default.
- W2913108622 hasConcept C2775910092 @default.
- W2913108622 hasConcept C2777123777 @default.
- W2913108622 hasConcept C2777810057 @default.
- W2913108622 hasConcept C2778173252 @default.
- W2913108622 hasConcept C2778938600 @default.
- W2913108622 hasConcept C2779738154 @default.
- W2913108622 hasConcept C2780930544 @default.
- W2913108622 hasConcept C2781210498 @default.
- W2913108622 hasConcept C2781442855 @default.
- W2913108622 hasConcept C42219234 @default.
- W2913108622 hasConcept C71924100 @default.
- W2913108622 hasConcept C98274493 @default.
- W2913108622 hasConceptScore W2913108622C126322002 @default.
- W2913108622 hasConceptScore W2913108622C134018914 @default.
- W2913108622 hasConceptScore W2913108622C170493617 @default.
- W2913108622 hasConceptScore W2913108622C185592680 @default.
- W2913108622 hasConceptScore W2913108622C2775910092 @default.
- W2913108622 hasConceptScore W2913108622C2777123777 @default.
- W2913108622 hasConceptScore W2913108622C2777810057 @default.
- W2913108622 hasConceptScore W2913108622C2778173252 @default.
- W2913108622 hasConceptScore W2913108622C2778938600 @default.
- W2913108622 hasConceptScore W2913108622C2779738154 @default.
- W2913108622 hasConceptScore W2913108622C2780930544 @default.
- W2913108622 hasConceptScore W2913108622C2781210498 @default.
- W2913108622 hasConceptScore W2913108622C2781442855 @default.
- W2913108622 hasConceptScore W2913108622C42219234 @default.
- W2913108622 hasConceptScore W2913108622C71924100 @default.
- W2913108622 hasConceptScore W2913108622C98274493 @default.
- W2913108622 hasIssue "2" @default.
- W2913108622 hasLocation W29131086221 @default.
- W2913108622 hasLocation W29131086222 @default.
- W2913108622 hasOpenAccess W2913108622 @default.
- W2913108622 hasPrimaryLocation W29131086221 @default.
- W2913108622 hasRelatedWork W1993364576 @default.
- W2913108622 hasRelatedWork W2035250490 @default.
- W2913108622 hasRelatedWork W2040290595 @default.
- W2913108622 hasRelatedWork W2058391632 @default.
- W2913108622 hasRelatedWork W2060088347 @default.
- W2913108622 hasRelatedWork W2084287988 @default.
- W2913108622 hasRelatedWork W2134141889 @default.
- W2913108622 hasRelatedWork W2147264850 @default.
- W2913108622 hasRelatedWork W2309843623 @default.
- W2913108622 hasRelatedWork W2500716294 @default.
- W2913108622 hasVolume "42" @default.
- W2913108622 isParatext "false" @default.
- W2913108622 isRetracted "false" @default.
- W2913108622 magId "2913108622" @default.
- W2913108622 workType "article" @default.