FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913111587> ?p ?o ?g. }

• W2913111587 endingPage "251" @default.
• W2913111587 startingPage "240" @default.
• W2913111587 abstract "Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. The genetic changes that underpin Wilms tumour have been defined by studies of familial cases and by unbiased DNA sequencing of tumour genomes. Together, these approaches have defined the landscape of cancer genes that are operative in Wilms tumour, many of which are intricately linked to the control of fetal nephrogenesis. Advances in our understanding of the germline and somatic genetic changes that underlie Wilms tumour may translate into better patient outcomes. Improvements in risk stratification have already been seen through the introduction of molecular biomarkers into clinical practice. A host of additional biomarkers are due to undergo clinical validation. Identifying actionable mutations has led to potential new targets, with some novel compounds undergoing testing in early phase trials. Avenues that warrant further exploration include targeting Wilms tumour cancer genes with a non-redundant role in nephrogenesis and targeting the fetal renal transcriptome." @default.
• W2913111587 created "2019-02-21" @default.
• W2913111587 creator A5035410237 @default.
• W2913111587 creator A5054914512 @default.
• W2913111587 creator A5067510543 @default.
• W2913111587 creator A5079185605 @default.
• W2913111587 date "2019-01-31" @default.
• W2913111587 modified "2023-10-18" @default.
• W2913111587 title "The genetic changes of Wilms tumour" @default.
• W2913111587 cites W1159598077 @default.
• W2913111587 cites W1528864462 @default.
• W2913111587 cites W1532769922 @default.
• W2913111587 cites W1592260247 @default.
• W2913111587 cites W1746044287 @default.
• W2913111587 cites W1838829111 @default.
• W2913111587 cites W1920408100 @default.
• W2913111587 cites W1940451643 @default.
• W2913111587 cites W1959116137 @default.
• W2913111587 cites W1967775656 @default.
• W2913111587 cites W1968608605 @default.
• W2913111587 cites W1974771871 @default.
• W2913111587 cites W1978376502 @default.
• W2913111587 cites W1979704967 @default.
• W2913111587 cites W1980763900 @default.
• W2913111587 cites W1983228128 @default.
• W2913111587 cites W1984916784 @default.
• W2913111587 cites W1985623793 @default.
• W2913111587 cites W1990541836 @default.
• W2913111587 cites W1990929423 @default.
• W2913111587 cites W1993885354 @default.
• W2913111587 cites W1993951035 @default.
• W2913111587 cites W1996210502 @default.
• W2913111587 cites W2004518477 @default.
• W2913111587 cites W2005542290 @default.
• W2913111587 cites W2006501903 @default.
• W2913111587 cites W2008769862 @default.
• W2913111587 cites W2013062145 @default.
• W2913111587 cites W2014982179 @default.
• W2913111587 cites W2022046681 @default.
• W2913111587 cites W2023905569 @default.
• W2913111587 cites W2033148781 @default.
• W2913111587 cites W2035482036 @default.
• W2913111587 cites W2039508988 @default.
• W2913111587 cites W2040548182 @default.
• W2913111587 cites W2046368638 @default.
• W2913111587 cites W2048838478 @default.
• W2913111587 cites W2051574088 @default.
• W2913111587 cites W2054051862 @default.
• W2913111587 cites W2056487792 @default.
• W2913111587 cites W2056621404 @default.
• W2913111587 cites W2056881795 @default.
• W2913111587 cites W2058283323 @default.
• W2913111587 cites W2058457132 @default.
• W2913111587 cites W2061477448 @default.
• W2913111587 cites W2063609798 @default.
• W2913111587 cites W2065964187 @default.
• W2913111587 cites W2068992396 @default.
• W2913111587 cites W2070267699 @default.
• W2913111587 cites W2071675221 @default.
• W2913111587 cites W2071922461 @default.
• W2913111587 cites W2073116924 @default.
• W2913111587 cites W2073478473 @default.
• W2913111587 cites W2081990599 @default.
• W2913111587 cites W2082904471 @default.
• W2913111587 cites W2084214818 @default.
• W2913111587 cites W2084585178 @default.
• W2913111587 cites W2091943025 @default.
• W2913111587 cites W2093248369 @default.
• W2913111587 cites W2095579742 @default.
• W2913111587 cites W2096476374 @default.
• W2913111587 cites W2102824378 @default.
• W2913111587 cites W2103679640 @default.
• W2913111587 cites W2104295203 @default.
• W2913111587 cites W2104966162 @default.
• W2913111587 cites W2105469253 @default.
• W2913111587 cites W2105507863 @default.
• W2913111587 cites W2105723991 @default.
• W2913111587 cites W2108419656 @default.
• W2913111587 cites W2114244323 @default.
• W2913111587 cites W2117694169 @default.
• W2913111587 cites W2120258802 @default.
• W2913111587 cites W2122992197 @default.
• W2913111587 cites W2124008135 @default.
• W2913111587 cites W2125926065 @default.
• W2913111587 cites W2126494274 @default.
• W2913111587 cites W2128647192 @default.
• W2913111587 cites W2128700722 @default.
• W2913111587 cites W2130552225 @default.
• W2913111587 cites W2131714856 @default.
• W2913111587 cites W2132302757 @default.
• W2913111587 cites W2133233410 @default.
• W2913111587 cites W2133583081 @default.
• W2913111587 cites W2134371698 @default.
• W2913111587 cites W2134599070 @default.
• W2913111587 cites W2134754923 @default.
• W2913111587 cites W2135745763 @default.
• W2913111587 cites W2137737429 @default.
• W2913111587 cites W2141480231 @default.

• next