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• W2913113544 abstract "Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base. Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular targeted therapy (MTT) is an option for advanced chordoma, but its therapeutic efficacy and safety have not been investigated systematically. Therefore, a systematic review was conducted on studies reporting MTT regimens for chordoma. Methods: Clinical trials, case series and case reports on chordoma MTT were identified using MEDLINE, Cochrane library and EMBASE, and systematically reviewed. Data on clinical outcomes, such as median overall survival, progression-free survival, response rate and adverse events (AEs) were extracted and analyzed. Results: Thirty-three eligible studies were selected for the systematic review, which indicated that imatinib and erlotinib were the most frequently used molecular targeted inhibitors (MTIs) for chordoma. For PDGFR-positive and/or EGFR-positive chordoma, clinical benefits were achieved with acceptable AEs. Monotherapy is preferred as the first-line of treatment, and combined drug therapy as the second-line treatment. In addition, the brachyury vaccine has shown promising results. Conclusions: The selection of MTIs for patients with advanced or relapsed chordoma should be based on gene mutation screening and immunohistochemistry (IHC). Monotherapy of TKIs is recommended as the first-line management, and combination therapy (two TKIs or TKI plus mTOR inhibitor) may be the choice for drug-resistant chordoma. Brachyury vaccine is a promising therapeutic strategy and requires more clinical trials to evaluate its safety and efficacy." @default.
• W2913113544 created "2019-02-21" @default.
• W2913113544 creator A5015069372 @default.
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• W2913113544 date "2019-02-01" @default.
• W2913113544 modified "2023-10-17" @default.
• W2913113544 title "Molecular Targeted Therapy in the Treatment of Chordoma: A Systematic Review" @default.
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• W2913113544 cites W1919009434 @default.
• W2913113544 cites W1966803171 @default.
• W2913113544 cites W1981667649 @default.
• W2913113544 cites W1986947159 @default.
• W2913113544 cites W1988995169 @default.
• W2913113544 cites W1989584038 @default.
• W2913113544 cites W1994257072 @default.
• W2913113544 cites W1995614906 @default.
• W2913113544 cites W1998682097 @default.
• W2913113544 cites W2000175978 @default.
• W2913113544 cites W2000611245 @default.
• W2913113544 cites W2008399534 @default.
• W2913113544 cites W2011813167 @default.
• W2913113544 cites W2015003519 @default.
• W2913113544 cites W2019607817 @default.
• W2913113544 cites W2021657948 @default.
• W2913113544 cites W2038864749 @default.
• W2913113544 cites W2039848937 @default.
• W2913113544 cites W2046760010 @default.
• W2913113544 cites W2049886568 @default.
• W2913113544 cites W2054238713 @default.
• W2913113544 cites W2056035945 @default.
• W2913113544 cites W2058634467 @default.
• W2913113544 cites W2059463471 @default.
• W2913113544 cites W2065895655 @default.
• W2913113544 cites W2071853977 @default.
• W2913113544 cites W2081801534 @default.
• W2913113544 cites W2082064668 @default.
• W2913113544 cites W2086281315 @default.
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• W2913113544 cites W2120155459 @default.
• W2913113544 cites W2123142428 @default.
• W2913113544 cites W2123534406 @default.
• W2913113544 cites W2134833483 @default.
• W2913113544 cites W2135813885 @default.
• W2913113544 cites W2143365343 @default.
• W2913113544 cites W2144717536 @default.
• W2913113544 cites W2149327445 @default.
• W2913113544 cites W2152248266 @default.
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• W2913113544 cites W2161601381 @default.
• W2913113544 cites W2163706047 @default.
• W2913113544 cites W2168654351 @default.
• W2913113544 cites W2170583701 @default.
• W2913113544 cites W2248477951 @default.
• W2913113544 cites W2259127335 @default.
• W2913113544 cites W2314600135 @default.
• W2913113544 cites W2337998143 @default.
• W2913113544 cites W2343398591 @default.
• W2913113544 cites W2417418989 @default.
• W2913113544 cites W2482317309 @default.
• W2913113544 cites W2529083835 @default.
• W2913113544 cites W2546379557 @default.
• W2913113544 cites W2611022823 @default.
• W2913113544 cites W2611323559 @default.
• W2913113544 cites W2634549532 @default.
• W2913113544 cites W2744814001 @default.
• W2913113544 cites W2745714473 @default.
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• W2913113544 cites W2772753261 @default.
• W2913113544 cites W2775466935 @default.
• W2913113544 cites W2798245996 @default.
• W2913113544 cites W2980550163 @default.
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• W2913113544 doi "https://doi.org/10.3389/fonc.2019.00030" @default.
• W2913113544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6367227" @default.
• W2913113544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30775316" @default.
• W2913113544 hasPublicationYear "2019" @default.
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