FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913125629> ?p ?o ?g. }

• W2913125629 endingPage "889" @default.
• W2913125629 startingPage "879" @default.
• W2913125629 abstract "Background and purpose Some clinical studies have reported increased myocardial infarction in people living with human immunodeficiency virus (HIV) taking the antiretroviral abacavir sulphate (ABC). Given that clinical studies contain confounding variables (e.g., HIV‐associated factors), we investigated the pharmacological effects of antiretrovirals on platelet function in HIV‐negative volunteers in order to identify mechanisms of increased cardiovascular risk. Experimental approach Platelets were isolated from healthy volunteers and HIV‐negative subjects enrolled on a Phase I clinical trial and platelet function evaluated using aggregometry and flow cytometry. In vivo platelet thromboembolism was monitored in anaesthetized mice. Key results Human platelet aggregation was unaffected by all antiretrovirals tested, but ABC treatment led uniquely to increased platelet granule release. ABC also interrupted NO‐mediated inhibition of platelet aggregation and increased in vivo aggregation in mice. Another antiretroviral, tenofovir, did not affect platelet function. Furthermore, aggregation and activation of platelets isolated from 20 subjects taking clinically relevant doses of tenofovir were comparable to baseline samples. Conclusions and implications ABC can enhance platelet activation, independently of variables that confound clinical studies, suggesting a potential pharmacological effect that is absent with tenofovir. Mechanistically, we propose that ABC enhances platelet degranulation and interrupts NO‐mediated platelet inhibition. The interaction of ABC with NO signalling is demonstrated by ABC‐mediated enhancement of aggregation in vivo and in vitro that persisted in the presence of NO. Although an association between ABC and platelet activation has not been confirmed in patients, these findings provide evidence of a mechanistic link between platelet activation and antiretroviral therapy." @default.
• W2913125629 created "2019-02-21" @default.
• W2913125629 creator A5006623516 @default.
• W2913125629 creator A5007876312 @default.
• W2913125629 creator A5009546060 @default.
• W2913125629 creator A5019284502 @default.
• W2913125629 creator A5020187152 @default.
• W2913125629 creator A5041869752 @default.
• W2913125629 creator A5049421833 @default.
• W2913125629 creator A5073460580 @default.
• W2913125629 creator A5087308498 @default.
• W2913125629 date "2019-03-14" @default.
• W2913125629 modified "2023-10-03" @default.
• W2913125629 title "Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus‐associated cardiovascular risk" @default.
• W2913125629 cites W1426208733 @default.
• W2913125629 cites W1489385133 @default.
• W2913125629 cites W1677033108 @default.
• W2913125629 cites W1965194684 @default.
• W2913125629 cites W2009303270 @default.
• W2913125629 cites W2037283562 @default.
• W2913125629 cites W2040245224 @default.
• W2913125629 cites W2062274686 @default.
• W2913125629 cites W2066256832 @default.
• W2913125629 cites W2066859478 @default.
• W2913125629 cites W2067007099 @default.
• W2913125629 cites W2085491702 @default.
• W2913125629 cites W2086948789 @default.
• W2913125629 cites W2092029818 @default.
• W2913125629 cites W2110846660 @default.
• W2913125629 cites W2149185709 @default.
• W2913125629 cites W2157138119 @default.
• W2913125629 cites W2171618058 @default.
• W2913125629 cites W2323452366 @default.
• W2913125629 cites W2332910040 @default.
• W2913125629 cites W2495049002 @default.
• W2913125629 cites W2517937861 @default.
• W2913125629 cites W2591786778 @default.
• W2913125629 cites W2595500836 @default.
• W2913125629 cites W2614048460 @default.
• W2913125629 cites W2617677419 @default.
• W2913125629 cites W2766119667 @default.
• W2913125629 cites W2766306821 @default.
• W2913125629 cites W2771328536 @default.
• W2913125629 cites W2792650449 @default.
• W2913125629 cites W4296391115 @default.
• W2913125629 cites W4296816736 @default.
• W2913125629 doi "https://doi.org/10.1111/bph.14589" @default.
• W2913125629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6433647" @default.
• W2913125629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30681136" @default.
• W2913125629 hasPublicationYear "2019" @default.
• W2913125629 type Work @default.
• W2913125629 sameAs 2913125629 @default.
• W2913125629 citedByCount "22" @default.
• W2913125629 countsByYear W29131256292019 @default.
• W2913125629 countsByYear W29131256292020 @default.
• W2913125629 countsByYear W29131256292021 @default.
• W2913125629 countsByYear W29131256292022 @default.
• W2913125629 countsByYear W29131256292023 @default.
• W2913125629 crossrefType "journal-article" @default.
• W2913125629 hasAuthorship W2913125629A5006623516 @default.
• W2913125629 hasAuthorship W2913125629A5007876312 @default.
• W2913125629 hasAuthorship W2913125629A5009546060 @default.
• W2913125629 hasAuthorship W2913125629A5019284502 @default.
• W2913125629 hasAuthorship W2913125629A5020187152 @default.
• W2913125629 hasAuthorship W2913125629A5041869752 @default.
• W2913125629 hasAuthorship W2913125629A5049421833 @default.
• W2913125629 hasAuthorship W2913125629A5073460580 @default.
• W2913125629 hasAuthorship W2913125629A5087308498 @default.
• W2913125629 hasBestOaLocation W29131256291 @default.
• W2913125629 hasConcept C126322002 @default.
• W2913125629 hasConcept C142462285 @default.
• W2913125629 hasConcept C150903083 @default.
• W2913125629 hasConcept C203014093 @default.
• W2913125629 hasConcept C207001950 @default.
• W2913125629 hasConcept C26291073 @default.
• W2913125629 hasConcept C2778914503 @default.
• W2913125629 hasConcept C2779465607 @default.
• W2913125629 hasConcept C2780076745 @default.
• W2913125629 hasConcept C2993143319 @default.
• W2913125629 hasConcept C3013748606 @default.
• W2913125629 hasConcept C3018697912 @default.
• W2913125629 hasConcept C71924100 @default.
• W2913125629 hasConcept C77350462 @default.
• W2913125629 hasConcept C86803240 @default.
• W2913125629 hasConcept C89560881 @default.
• W2913125629 hasConcept C98274493 @default.
• W2913125629 hasConceptScore W2913125629C126322002 @default.
• W2913125629 hasConceptScore W2913125629C142462285 @default.
• W2913125629 hasConceptScore W2913125629C150903083 @default.
• W2913125629 hasConceptScore W2913125629C203014093 @default.
• W2913125629 hasConceptScore W2913125629C207001950 @default.
• W2913125629 hasConceptScore W2913125629C26291073 @default.
• W2913125629 hasConceptScore W2913125629C2778914503 @default.
• W2913125629 hasConceptScore W2913125629C2779465607 @default.
• W2913125629 hasConceptScore W2913125629C2780076745 @default.
• W2913125629 hasConceptScore W2913125629C2993143319 @default.
• W2913125629 hasConceptScore W2913125629C3013748606 @default.
• W2913125629 hasConceptScore W2913125629C3018697912 @default.

• next