FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913136169> ?p ?o ?g. }

• W2913136169 abstract "Engineering inorganic nanoparticles with a biocompatible shell to improve their physicochemical properties is a vital step in taking advantage of their superior magnetic, optical, and photothermal properties as multifunctional molecular imaging probes for disease diagnosis and treatment. The grafting/peeling-off strategy we developed for nanoparticle surface coating can fully control the targeting capability of functional nanoprobes by changing their colloidal behaviors such as diffusion and sedimentation rates at the desired sites. We demonstrated that a cleavable coating layer initially immobilized on the surface of magnetic resonance imaging probes not only makes the nanoparticles water-soluble but also can be selectively removed by specific enzymes, thereby resulting in a significant decrease of their water solubility in an enzyme-rich environment. Upon removal of surface coating, the changes in hydrodynamic size and surface charges of nanoprobes as a result of interacting with biomolecules and proteins lead to dramatic changes in their in vivo colloidal behaviors (i.e., slow diffusion rates, tendency to aggregate and precipitate), which were quantitatively evaluated by examining changes in their hydrodynamic sizes, magnetic properties, and count rates during the size measurement. Because the retention time of nanoprobes within the tumor tissues depends on the uptake and excretion rate of the nanoprobes through the tumors, selective activation of nanoprobes by a specific enzyme resulted in much higher tumor accumulation and longer retention time within the tumors than that of the inactive nanoprobes, which passively passed through the tumors. The imaging contrast effect of tumors using activatable nanoprobes was significantly improved over using inactive probes. Therefore, the grafting/peeling-off strategy, as a general design approach for surface modification of nanoprobes, offers a promising and highly efficient way to render the nanoparticles suitable for targeted imaging of tumors." @default.
• W2913136169 created "2019-02-21" @default.
• W2913136169 creator A5007325506 @default.
• W2913136169 creator A5021129669 @default.
• W2913136169 creator A5022499603 @default.
• W2913136169 creator A5025751238 @default.
• W2913136169 creator A5040728794 @default.
• W2913136169 creator A5058183558 @default.
• W2913136169 creator A5059927247 @default.
• W2913136169 creator A5061563698 @default.
• W2913136169 creator A5071558335 @default.
• W2913136169 creator A5073137670 @default.
• W2913136169 creator A5075963891 @default.
• W2913136169 date "2019-01-28" @default.
• W2913136169 modified "2023-10-18" @default.
• W2913136169 title "Controlled Nano–Bio Interface of Functional Nanoprobes for in Vivo Monitoring Enzyme Activity in Tumors" @default.
• W2913136169 cites W1572736799 @default.
• W2913136169 cites W1592617873 @default.
• W2913136169 cites W1967452415 @default.
• W2913136169 cites W1973831032 @default.
• W2913136169 cites W1976178939 @default.
• W2913136169 cites W1976569701 @default.
• W2913136169 cites W1982094144 @default.
• W2913136169 cites W1996844579 @default.
• W2913136169 cites W2014011204 @default.
• W2913136169 cites W2014779844 @default.
• W2913136169 cites W2020706877 @default.
• W2913136169 cites W2024942244 @default.
• W2913136169 cites W2044791030 @default.
• W2913136169 cites W2057317778 @default.
• W2913136169 cites W2060416946 @default.
• W2913136169 cites W2060954700 @default.
• W2913136169 cites W2062155582 @default.
• W2913136169 cites W2068085644 @default.
• W2913136169 cites W2069688996 @default.
• W2913136169 cites W2069693261 @default.
• W2913136169 cites W2093718909 @default.
• W2913136169 cites W2106739895 @default.
• W2913136169 cites W2107910518 @default.
• W2913136169 cites W2115552839 @default.
• W2913136169 cites W2116331383 @default.
• W2913136169 cites W2126163864 @default.
• W2913136169 cites W2150772197 @default.
• W2913136169 cites W2158558808 @default.
• W2913136169 cites W2159907612 @default.
• W2913136169 cites W2161946327 @default.
• W2913136169 cites W2164564532 @default.
• W2913136169 cites W2170916169 @default.
• W2913136169 cites W2255871307 @default.
• W2913136169 cites W2328639389 @default.
• W2913136169 cites W2332957914 @default.
• W2913136169 cites W2344644350 @default.
• W2913136169 cites W2402319960 @default.
• W2913136169 cites W2415307463 @default.
• W2913136169 cites W2556664795 @default.
• W2913136169 cites W2561324329 @default.
• W2913136169 cites W2589349833 @default.
• W2913136169 cites W2594605573 @default.
• W2913136169 cites W2600929793 @default.
• W2913136169 cites W2602072096 @default.
• W2913136169 cites W2606126811 @default.
• W2913136169 cites W2760971081 @default.
• W2913136169 cites W2767090914 @default.
• W2913136169 cites W2767448226 @default.
• W2913136169 cites W2773580742 @default.
• W2913136169 cites W2775348980 @default.
• W2913136169 cites W2800898645 @default.
• W2913136169 cites W2884304605 @default.
• W2913136169 doi "https://doi.org/10.1021/acsnano.8b05825" @default.
• W2913136169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673268" @default.
• W2913136169 hasPublicationYear "2019" @default.
• W2913136169 type Work @default.
• W2913136169 sameAs 2913136169 @default.
• W2913136169 citedByCount "5" @default.
• W2913136169 countsByYear W29131361692019 @default.
• W2913136169 countsByYear W29131361692020 @default.
• W2913136169 countsByYear W29131361692022 @default.
• W2913136169 crossrefType "journal-article" @default.
• W2913136169 hasAuthorship W2913136169A5007325506 @default.
• W2913136169 hasAuthorship W2913136169A5021129669 @default.
• W2913136169 hasAuthorship W2913136169A5022499603 @default.
• W2913136169 hasAuthorship W2913136169A5025751238 @default.
• W2913136169 hasAuthorship W2913136169A5040728794 @default.
• W2913136169 hasAuthorship W2913136169A5058183558 @default.
• W2913136169 hasAuthorship W2913136169A5059927247 @default.
• W2913136169 hasAuthorship W2913136169A5061563698 @default.
• W2913136169 hasAuthorship W2913136169A5071558335 @default.
• W2913136169 hasAuthorship W2913136169A5073137670 @default.
• W2913136169 hasAuthorship W2913136169A5075963891 @default.
• W2913136169 hasConcept C115537861 @default.
• W2913136169 hasConcept C12554922 @default.
• W2913136169 hasConcept C127413603 @default.
• W2913136169 hasConcept C147789679 @default.
• W2913136169 hasConcept C150903083 @default.
• W2913136169 hasConcept C155672457 @default.
• W2913136169 hasConcept C171250308 @default.
• W2913136169 hasConcept C182606246 @default.
• W2913136169 hasConcept C185592680 @default.
• W2913136169 hasConcept C192562407 @default.
• W2913136169 hasConcept C207001950 @default.

• next