FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913140988> ?p ?o ?g. }

• W2913140988 endingPage "59" @default.
• W2913140988 startingPage "59" @default.
• W2913140988 abstract "Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (i-Pr) and cationic (–NH2) or anionic (–COOH) groups. Standard viability assays were used to evaluate the anticancer potential of the water-soluble dendrimers against PC-3 prostate and HT-29 colon cancer cell lines, as well as non-cancerous mouse NIH3T3 fibroblasts. It could be demonstrated that the anticancer activity against PC-3 cells was considerably improved when both chlorambucil and –NH2 (cationic) groups were present on the dendrimer surface (1b). Additionally, this dendrimer showed activity only against the prostate cancer cells (PC-3), while it did not affect colon cancer cells and fibroblasts significantly. The cationic chlorambucil-dendrimer 1b blocks PC-3 cells in the G2/M phase and induces caspase independent apoptosis." @default.
• W2913140988 created "2019-02-21" @default.
• W2913140988 creator A5012892909 @default.
• W2913140988 creator A5021106279 @default.
• W2913140988 creator A5034743883 @default.
• W2913140988 creator A5049586619 @default.
• W2913140988 creator A5075458598 @default.
• W2913140988 date "2019-02-01" @default.
• W2913140988 modified "2023-10-16" @default.
• W2913140988 title "Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH2 Core and Evaluation of Their Anticancer Activity" @default.
• W2913140988 cites W1269071996 @default.
• W2913140988 cites W1825085207 @default.
• W2913140988 cites W1964447134 @default.
• W2913140988 cites W1977337950 @default.
• W2913140988 cites W1994936258 @default.
• W2913140988 cites W2005240801 @default.
• W2913140988 cites W2012398957 @default.
• W2913140988 cites W2029626710 @default.
• W2913140988 cites W2041072987 @default.
• W2913140988 cites W2045213721 @default.
• W2913140988 cites W2052706007 @default.
• W2913140988 cites W2061989935 @default.
• W2913140988 cites W2062512366 @default.
• W2913140988 cites W2068951857 @default.
• W2913140988 cites W2083510187 @default.
• W2913140988 cites W2086069830 @default.
• W2913140988 cites W2088467380 @default.
• W2913140988 cites W2089987199 @default.
• W2913140988 cites W2092832688 @default.
• W2913140988 cites W2099145932 @default.
• W2913140988 cites W2111677437 @default.
• W2913140988 cites W2120075848 @default.
• W2913140988 cites W2135986253 @default.
• W2913140988 cites W2163348695 @default.
• W2913140988 cites W2281598886 @default.
• W2913140988 cites W2301823896 @default.
• W2913140988 cites W2326175431 @default.
• W2913140988 cites W2332054087 @default.
• W2913140988 cites W2510763357 @default.
• W2913140988 cites W2743065036 @default.
• W2913140988 cites W2788989265 @default.
• W2913140988 cites W2799763646 @default.
• W2913140988 cites W2806949810 @default.
• W2913140988 cites W2890188017 @default.
• W2913140988 cites W2890263694 @default.
• W2913140988 cites W4249636867 @default.
• W2913140988 doi "https://doi.org/10.3390/pharmaceutics11020059" @default.
• W2913140988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6409784" @default.
• W2913140988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717083" @default.
• W2913140988 hasPublicationYear "2019" @default.
• W2913140988 type Work @default.
• W2913140988 sameAs 2913140988 @default.
• W2913140988 citedByCount "12" @default.
• W2913140988 countsByYear W29131409882020 @default.
• W2913140988 countsByYear W29131409882021 @default.
• W2913140988 countsByYear W29131409882022 @default.
• W2913140988 countsByYear W29131409882023 @default.
• W2913140988 crossrefType "journal-article" @default.
• W2913140988 hasAuthorship W2913140988A5012892909 @default.
• W2913140988 hasAuthorship W2913140988A5021106279 @default.
• W2913140988 hasAuthorship W2913140988A5034743883 @default.
• W2913140988 hasAuthorship W2913140988A5049586619 @default.
• W2913140988 hasAuthorship W2913140988A5075458598 @default.
• W2913140988 hasBestOaLocation W29131409881 @default.
• W2913140988 hasConcept C109316439 @default.
• W2913140988 hasConcept C112613896 @default.
• W2913140988 hasConcept C126322002 @default.
• W2913140988 hasConcept C178790620 @default.
• W2913140988 hasConcept C183882617 @default.
• W2913140988 hasConcept C185592680 @default.
• W2913140988 hasConcept C202751555 @default.
• W2913140988 hasConcept C2776694085 @default.
• W2913140988 hasConcept C2776755627 @default.
• W2913140988 hasConcept C2777866208 @default.
• W2913140988 hasConcept C502942594 @default.
• W2913140988 hasConcept C521977710 @default.
• W2913140988 hasConcept C55493867 @default.
• W2913140988 hasConcept C55637122 @default.
• W2913140988 hasConcept C71924100 @default.
• W2913140988 hasConceptScore W2913140988C109316439 @default.
• W2913140988 hasConceptScore W2913140988C112613896 @default.
• W2913140988 hasConceptScore W2913140988C126322002 @default.
• W2913140988 hasConceptScore W2913140988C178790620 @default.
• W2913140988 hasConceptScore W2913140988C183882617 @default.
• W2913140988 hasConceptScore W2913140988C185592680 @default.
• W2913140988 hasConceptScore W2913140988C202751555 @default.
• W2913140988 hasConceptScore W2913140988C2776694085 @default.
• W2913140988 hasConceptScore W2913140988C2776755627 @default.
• W2913140988 hasConceptScore W2913140988C2777866208 @default.
• W2913140988 hasConceptScore W2913140988C502942594 @default.
• W2913140988 hasConceptScore W2913140988C521977710 @default.
• W2913140988 hasConceptScore W2913140988C55493867 @default.
• W2913140988 hasConceptScore W2913140988C55637122 @default.
• W2913140988 hasConceptScore W2913140988C71924100 @default.
• W2913140988 hasIssue "2" @default.
• W2913140988 hasLocation W29131409881 @default.
• W2913140988 hasLocation W29131409882 @default.
• W2913140988 hasLocation W29131409883 @default.

• next