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- W2913149915 startingPage "568" @default.
- W2913149915 abstract "Colour patterns in butterflies and moths are crucial traits for adaptation. Previous investigations have highlighted genes responsible for pigmentation (ie yellow and ebony). However, the mechanisms by which these genes are regulated in lepidopteran insects remain poorly understood. To elucidate this, molecular studies involving dipterans have largely analysed the cis-regulatory regions of pigmentation genes and have revealed cis-regulatory modularity. Here, we used well-developed transgenic techniques in Bombyx mori and demonstrated that cis-regulatory modularity controls tissue-specific expression of the yellow gene. We first identified which body parts are regulated by the yellow gene via black pigmentation. We then isolated three discrete regulatory elements driving tissue-specific gene expression in three regions of B. mori larvae. Finally, we found that there is no apparent sequence conservation of cis-regulatory regions between B. mori and Drosophila melanogaster, and no expression driven by the regulatory regions of one species when introduced into the other species. Therefore, the trans-regulatory landscapes of the yellow gene differ significantly between the two taxa. The results of this study confirm that lepidopteran species use cis-regulatory modules to control gene expression related to pigmentation, and represent a powerful cadre of transgenic tools for studying evolutionary developmental mechanisms." @default.
- W2913149915 created "2019-02-21" @default.
- W2913149915 creator A5016729795 @default.
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- W2913149915 creator A5073041790 @default.
- W2913149915 creator A5080756133 @default.
- W2913149915 creator A5083794408 @default.
- W2913149915 date "2019-03-06" @default.
- W2913149915 modified "2023-10-14" @default.
- W2913149915 title "Modular<i>cis</i>‐regulatory logic of<i>yellow</i>gene expression in silkmoth larvae" @default.
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- W2913149915 doi "https://doi.org/10.1111/imb.12574" @default.
- W2913149915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6849593" @default.
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- W2913149915 hasPublicationYear "2019" @default.
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