FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913151980> ?p ?o ?g. }

• W2913151980 endingPage "401" @default.
• W2913151980 startingPage "381" @default.
• W2913151980 abstract "The introduction of chimeric antigen receptors (CARs) to augment the anticancer activity of immune cells represents one of the major clinical advances in recent years. This work demonstrates that sorted CAR natural killer (NK) cells have improved antileukemia activity compared to control NK cells that lack a functional CAR. However, in terms of viability, effectiveness, risk of side effects, and clinical practicality and applicability, an important question is whether gene-modified NK cell lines represent better CAR effector cells than primary human donor CAR-NK (CAR-dNK) cells. Comparison of the functional activities of sorted CAR-NK cells generated using the NK-92 cell line with those generated from primary human dNK cells demonstrated that CAR-NK-92 cells had stronger cytotoxic activity against leukemia cells compared to CAR-dNK cells. CAR-NK-92 and CAR-dNK cells had similar CD107a surface expression upon co-incubation with leukemia cells. However, CAR-NK-92 cells secreted higher granzyme A and interleukin-17A levels, while CAR-dNK cells secreted more tumor necrosis factor alpha, interferon gamma, and granulysin. In addition, CAR-NK-92 cells revealed a significantly higher potential for adverse side effects against nonmalignant cells. In short, this work shows the feasibility for further development of CAR-NK strategies to treat leukemia." @default.
• W2913151980 created "2019-02-21" @default.
• W2913151980 creator A5011083669 @default.
• W2913151980 creator A5014126648 @default.
• W2913151980 creator A5028578885 @default.
• W2913151980 creator A5031473913 @default.
• W2913151980 creator A5035237130 @default.
• W2913151980 creator A5042229264 @default.
• W2913151980 creator A5047609890 @default.
• W2913151980 creator A5053578678 @default.
• W2913151980 creator A5054362291 @default.
• W2913151980 creator A5055400659 @default.
• W2913151980 creator A5059166426 @default.
• W2913151980 creator A5059579735 @default.
• W2913151980 creator A5063579977 @default.
• W2913151980 creator A5064741787 @default.
• W2913151980 creator A5066232501 @default.
• W2913151980 date "2019-04-01" @default.
• W2913151980 modified "2023-10-14" @default.
• W2913151980 title "Preclinical Assessment of Suitable Natural Killer Cell Sources for Chimeric Antigen Receptor Natural Killer–Based “Off-the-Shelf” Acute Myeloid Leukemia Immunotherapies" @default.
• W2913151980 cites W1166263056 @default.
• W2913151980 cites W1964548129 @default.
• W2913151980 cites W1969644995 @default.
• W2913151980 cites W1976187277 @default.
• W2913151980 cites W1977778943 @default.
• W2913151980 cites W2000853857 @default.
• W2913151980 cites W2016523043 @default.
• W2913151980 cites W2022069273 @default.
• W2913151980 cites W2025141198 @default.
• W2913151980 cites W2057781614 @default.
• W2913151980 cites W2070387456 @default.
• W2913151980 cites W2106632394 @default.
• W2913151980 cites W2138076568 @default.
• W2913151980 cites W2147068163 @default.
• W2913151980 cites W2260497117 @default.
• W2913151980 cites W2331962566 @default.
• W2913151980 cites W2332619013 @default.
• W2913151980 cites W2346685799 @default.
• W2913151980 cites W2598689365 @default.
• W2913151980 cites W2615682320 @default.
• W2913151980 cites W2735011415 @default.
• W2913151980 cites W2749736858 @default.
• W2913151980 cites W2752591535 @default.
• W2913151980 cites W2756774216 @default.
• W2913151980 cites W2810715813 @default.
• W2913151980 cites W2887710665 @default.
• W2913151980 cites W2896565106 @default.
• W2913151980 cites W4236468126 @default.
• W2913151980 cites W4293247451 @default.
• W2913151980 doi "https://doi.org/10.1089/hum.2018.247" @default.
• W2913151980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30734584" @default.
• W2913151980 hasPublicationYear "2019" @default.
• W2913151980 type Work @default.
• W2913151980 sameAs 2913151980 @default.
• W2913151980 citedByCount "36" @default.
• W2913151980 countsByYear W29131519802019 @default.
• W2913151980 countsByYear W29131519802020 @default.
• W2913151980 countsByYear W29131519802021 @default.
• W2913151980 countsByYear W29131519802022 @default.
• W2913151980 countsByYear W29131519802023 @default.
• W2913151980 crossrefType "journal-article" @default.
• W2913151980 hasAuthorship W2913151980A5011083669 @default.
• W2913151980 hasAuthorship W2913151980A5014126648 @default.
• W2913151980 hasAuthorship W2913151980A5028578885 @default.
• W2913151980 hasAuthorship W2913151980A5031473913 @default.
• W2913151980 hasAuthorship W2913151980A5035237130 @default.
• W2913151980 hasAuthorship W2913151980A5042229264 @default.
• W2913151980 hasAuthorship W2913151980A5047609890 @default.
• W2913151980 hasAuthorship W2913151980A5053578678 @default.
• W2913151980 hasAuthorship W2913151980A5054362291 @default.
• W2913151980 hasAuthorship W2913151980A5055400659 @default.
• W2913151980 hasAuthorship W2913151980A5059166426 @default.
• W2913151980 hasAuthorship W2913151980A5059579735 @default.
• W2913151980 hasAuthorship W2913151980A5063579977 @default.
• W2913151980 hasAuthorship W2913151980A5064741787 @default.
• W2913151980 hasAuthorship W2913151980A5066232501 @default.
• W2913151980 hasConcept C129374314 @default.
• W2913151980 hasConcept C149532602 @default.
• W2913151980 hasConcept C154317977 @default.
• W2913151980 hasConcept C167672396 @default.
• W2913151980 hasConcept C17991360 @default.
• W2913151980 hasConcept C183193105 @default.
• W2913151980 hasConcept C183315844 @default.
• W2913151980 hasConcept C202751555 @default.
• W2913151980 hasConcept C203014093 @default.
• W2913151980 hasConcept C206191192 @default.
• W2913151980 hasConcept C2776062744 @default.
• W2913151980 hasConcept C2776090121 @default.
• W2913151980 hasConcept C2777701055 @default.
• W2913151980 hasConcept C2778102761 @default.
• W2913151980 hasConcept C2778729363 @default.
• W2913151980 hasConcept C2780380082 @default.
• W2913151980 hasConcept C28651165 @default.
• W2913151980 hasConcept C3875195 @default.
• W2913151980 hasConcept C502942594 @default.
• W2913151980 hasConcept C55493867 @default.
• W2913151980 hasConcept C86803240 @default.
• W2913151980 hasConcept C8891405 @default.

• next