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- W2913155102 abstract "Class II PI3Ks synthetize two different phosphoinositides, PI(3)P and PI(3,4)P2, in distinct cellular compartments. PI3K-C2α plays a central role in clathrin-mediated endocytosis, vesicular trafficking, and mitosis. PI3K-C2β is activated by growth factors and is involved in cell migration and mTOR signaling repression. PI3K-C2γ localizes on early endosomes and controls Akt2 activation and glycogen storage in the liver. The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate inositol phospholipids, thereby controlling membrane lipid composition and regulating a wide range of intracellular processes, including vesicular trafficking and signal transduction. Despite the vast knowledge on class I PI3Ks, recent studies are only now revealing the importance of class II PI3Ks in cell proliferation, survival, and migration. Increasing evidence suggests that the three class II PI3Ks isoforms (PI3K-C2α, PI3K-C2β, and PI3K-C2γ) have distinct and non-overlapping cellular roles. Here, we focus on the cellular functions of class II PI3Ks in different cell systems and underline the emerging importance of these enzymes in various physiological and pathological contexts. The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate inositol phospholipids, thereby controlling membrane lipid composition and regulating a wide range of intracellular processes, including vesicular trafficking and signal transduction. Despite the vast knowledge on class I PI3Ks, recent studies are only now revealing the importance of class II PI3Ks in cell proliferation, survival, and migration. Increasing evidence suggests that the three class II PI3Ks isoforms (PI3K-C2α, PI3K-C2β, and PI3K-C2γ) have distinct and non-overlapping cellular roles. Here, we focus on the cellular functions of class II PI3Ks in different cell systems and underline the emerging importance of these enzymes in various physiological and pathological contexts." @default.
- W2913155102 created "2019-02-21" @default.
- W2913155102 creator A5016219694 @default.
- W2913155102 creator A5045008462 @default.
- W2913155102 creator A5059257974 @default.
- W2913155102 creator A5064395568 @default.
- W2913155102 creator A5075168526 @default.
- W2913155102 date "2019-04-01" @default.
- W2913155102 modified "2023-10-17" @default.
- W2913155102 title "Class II PI3K Functions in Cell Biology and Disease" @default.
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