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- W2913163752 abstract "To discover novel structural compounds which are producted by endophytic fungi, a primary chemical profiling of Camptotheca acuminata Decne derived endophytic fungus Penicillum polonicum had been taken. Two new compounds β-lactone polonicin A (1) and enoic acid polonicin B (2) together with seven known compounds 3-9 were isolated from Penicillum polonicum obtained from C. acuminata. The structures of the new compounds 1 and 2 were identified by modern spectrum technology including detailed 1D, 2D NMR and MS data analyses. When tested against HepG2 hepatocellular carcinoma (HCC) cell lines, compounds 4-8 showed moderate anti-HCC activity. In addition, compound 1-3 have effects on increasing GLUT4 translocation and glucose uptake in vitro. Compound 1 showed the strongest glucose uptake and GLUT4 translocation activities in rat skeleton (L6) myoblast cell line with enhancements of 1.8 and 2.1 folds respectively compared to the control." @default.
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- W2913163752 date "2019-02-13" @default.
- W2913163752 modified "2023-09-24" @default.
- W2913163752 title "Two new compounds of <i>Penicillium polonicum</i>, an endophytic fungus from <i>Camptotheca acuminata</i> Decne" @default.
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- W2913163752 doi "https://doi.org/10.1080/14786419.2019.1569003" @default.
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