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- W2913163962 endingPage "381" @default.
- W2913163962 startingPage "347" @default.
- W2913163962 abstract "Bromodomains (BRDs) are functional modules which recognize acetylated lysines on the surface of proteins. Such post-translational modifications exist in thousands of human proteins and play a crucial role in diverse signaling networks. It has been shown that by recognizing acetylated lysines on histone tails, BRDs regulate the transcription of specific genes. Their potential as drug targets was demonstrated in 2010 when JQ1, presented as an inhibitor of the BRD containing protein BRD4, was shown to suppress cancer cell proliferation. The knowledge about BRDs and their role in signaling and diseases has dramatically increased over the past few years and many of them are now accepted as promising drug targets for various diseases. This chapter provides an overview of the structure and function of BRDs, their role in diseases, inhibitors known to date, and the different strategies used for targeting BRDs." @default.
- W2913163962 created "2019-02-21" @default.
- W2913163962 creator A5018736728 @default.
- W2913163962 creator A5038168057 @default.
- W2913163962 creator A5057283799 @default.
- W2913163962 date "2019-02-06" @default.
- W2913163962 modified "2023-09-25" @default.
- W2913163962 title "Bromodomains: Promising Targets for Drug Discovery" @default.
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