FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913168473> ?p ?o ?g. }

• W2913168473 abstract "Abstract Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the GC reaction after targeting antigen to MHCII in (i) a defined model with T and B cells of known specificity using adjuvant-free vaccine proteins, and (ii) an infectious disease model using a DNA vaccine. MHCII-targeting enhanced presentation of peptide: MHCII on APCs, and increased the numbers of GC B cells, T FH , and plasma cells. Antibodies appeared earlier and levels were increased. BCR of GC B cells and serum antibodies had increased avidity for antigen. The improved responses required cross-linking of BCR and MHCII in either cis or trans . The enhanced GC reaction induced by MHCII-targeting of antigen has clear implications for design of more efficient subunit vaccines." @default.
• W2913168473 created "2019-02-21" @default.
• W2913168473 creator A5006409652 @default.
• W2913168473 creator A5013182847 @default.
• W2913168473 creator A5046032682 @default.
• W2913168473 creator A5052742087 @default.
• W2913168473 creator A5058253485 @default.
• W2913168473 creator A5067636114 @default.
• W2913168473 creator A5068330245 @default.
• W2913168473 creator A5083802834 @default.
• W2913168473 date "2019-02-11" @default.
• W2913168473 modified "2023-10-15" @default.
• W2913168473 title "Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules" @default.
• W2913168473 cites W1544927019 @default.
• W2913168473 cites W1622542255 @default.
• W2913168473 cites W1666706706 @default.
• W2913168473 cites W1821269744 @default.
• W2913168473 cites W1892258064 @default.
• W2913168473 cites W1962592683 @default.
• W2913168473 cites W1966670960 @default.
• W2913168473 cites W1976750616 @default.
• W2913168473 cites W1984591972 @default.
• W2913168473 cites W1985033543 @default.
• W2913168473 cites W1988975403 @default.
• W2913168473 cites W1989134497 @default.
• W2913168473 cites W1991497659 @default.
• W2913168473 cites W1992949591 @default.
• W2913168473 cites W1998953208 @default.
• W2913168473 cites W1999985136 @default.
• W2913168473 cites W2001016015 @default.
• W2913168473 cites W2008471218 @default.
• W2913168473 cites W2012427800 @default.
• W2913168473 cites W2013671168 @default.
• W2913168473 cites W2013856810 @default.
• W2913168473 cites W2014113929 @default.
• W2913168473 cites W2016054852 @default.
• W2913168473 cites W2019206924 @default.
• W2913168473 cites W2022615852 @default.
• W2913168473 cites W2044809556 @default.
• W2913168473 cites W2046410511 @default.
• W2913168473 cites W2065818546 @default.
• W2913168473 cites W2066094880 @default.
• W2913168473 cites W2071380288 @default.
• W2913168473 cites W2075130635 @default.
• W2913168473 cites W2094999215 @default.
• W2913168473 cites W2098744660 @default.
• W2913168473 cites W2100761378 @default.
• W2913168473 cites W2108527881 @default.
• W2913168473 cites W2137670912 @default.
• W2913168473 cites W2138071207 @default.
• W2913168473 cites W2138582495 @default.
• W2913168473 cites W2141354546 @default.
• W2913168473 cites W2160762238 @default.
• W2913168473 cites W2169156878 @default.
• W2913168473 cites W2212428564 @default.
• W2913168473 cites W2286883753 @default.
• W2913168473 cites W2381153372 @default.
• W2913168473 cites W2396908022 @default.
• W2913168473 cites W2521133415 @default.
• W2913168473 cites W2526750143 @default.
• W2913168473 cites W2550740111 @default.
• W2913168473 cites W2603632652 @default.
• W2913168473 cites W2783696884 @default.
• W2913168473 cites W4246504300 @default.
• W2913168473 cites W4313347699 @default.
• W2913168473 doi "https://doi.org/10.1038/s41541-019-0101-0" @default.
• W2913168473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6370881" @default.
• W2913168473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30775000" @default.
• W2913168473 hasPublicationYear "2019" @default.
• W2913168473 type Work @default.
• W2913168473 sameAs 2913168473 @default.
• W2913168473 citedByCount "24" @default.
• W2913168473 countsByYear W29131684732019 @default.
• W2913168473 countsByYear W29131684732021 @default.
• W2913168473 countsByYear W29131684732022 @default.
• W2913168473 countsByYear W29131684732023 @default.
• W2913168473 crossrefType "journal-article" @default.
• W2913168473 hasAuthorship W2913168473A5006409652 @default.
• W2913168473 hasAuthorship W2913168473A5013182847 @default.
• W2913168473 hasAuthorship W2913168473A5046032682 @default.
• W2913168473 hasAuthorship W2913168473A5052742087 @default.
• W2913168473 hasAuthorship W2913168473A5058253485 @default.
• W2913168473 hasAuthorship W2913168473A5067636114 @default.
• W2913168473 hasAuthorship W2913168473A5068330245 @default.
• W2913168473 hasAuthorship W2913168473A5083802834 @default.
• W2913168473 hasBestOaLocation W29131684731 @default.
• W2913168473 hasConcept C147483822 @default.
• W2913168473 hasConcept C159047783 @default.
• W2913168473 hasConcept C159654299 @default.
• W2913168473 hasConcept C179223381 @default.
• W2913168473 hasConcept C185592680 @default.
• W2913168473 hasConcept C203014093 @default.
• W2913168473 hasConcept C207936829 @default.
• W2913168473 hasConcept C2776090121 @default.
• W2913168473 hasConcept C2777863537 @default.
• W2913168473 hasConcept C2778453870 @default.
• W2913168473 hasConcept C67662055 @default.
• W2913168473 hasConcept C83464605 @default.
• W2913168473 hasConcept C86803240 @default.
• W2913168473 hasConcept C8891405 @default.

• next