FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913171106> ?p ?o ?g. }

• W2913171106 abstract "Abstract Regulating the intrinsic interactions between blood vessels and nerve cells has the potential to enhance repair and regeneration of the central nervous system. Here, we evaluate the efficacy of aligned microvessels to induce and control directional axon growth from neural progenitor cells in vitro and host axons in a rat spinal cord injury model. Interstitial fluid flow aligned microvessels generated from co-cultures of cerebral-derived endothelial cells and pericytes in a three-dimensional scaffold. The endothelial barrier function was evaluated by immunostaining for tight junction proteins and quantifying the permeability coefficient (~10 −7 cm/s). Addition of neural progenitor cells to the co-culture resulted in the extension of Tuj-positive axons in the direction of the microvessels. To validate these findings in vivo , scaffolds were transplanted into an acute spinal cord hemisection injury with microvessels aligned with the rostral-caudal direction. At three weeks post-surgery, sagittal sections indicated close alignment between the host axons and the transplanted microvessels. Overall, this work demonstrates the efficacy of exploiting neurovascular interaction to direct axon growth in the injured spinal cord and the potential to use this strategy to facilitate central nervous system regeneration." @default.
• W2913171106 created "2019-02-21" @default.
• W2913171106 creator A5002247726 @default.
• W2913171106 creator A5016359152 @default.
• W2913171106 creator A5020651722 @default.
• W2913171106 creator A5044996960 @default.
• W2913171106 creator A5058356253 @default.
• W2913171106 creator A5059985761 @default.
• W2913171106 creator A5068872463 @default.
• W2913171106 creator A5073440135 @default.
• W2913171106 date "2019-02-18" @default.
• W2913171106 modified "2023-10-02" @default.
• W2913171106 title "Harnessing neurovascular interaction to guide axon growth" @default.
• W2913171106 cites W1504922538 @default.
• W2913171106 cites W1520572285 @default.
• W2913171106 cites W1575802919 @default.
• W2913171106 cites W1608769739 @default.
• W2913171106 cites W1937584992 @default.
• W2913171106 cites W1965681567 @default.
• W2913171106 cites W1966672254 @default.
• W2913171106 cites W1973524523 @default.
• W2913171106 cites W1976950876 @default.
• W2913171106 cites W1978496495 @default.
• W2913171106 cites W1979040586 @default.
• W2913171106 cites W1981188246 @default.
• W2913171106 cites W1981854539 @default.
• W2913171106 cites W1986446050 @default.
• W2913171106 cites W1996924444 @default.
• W2913171106 cites W2000426718 @default.
• W2913171106 cites W2001952247 @default.
• W2913171106 cites W2005215351 @default.
• W2913171106 cites W2006560625 @default.
• W2913171106 cites W2009582775 @default.
• W2913171106 cites W2013281213 @default.
• W2913171106 cites W2014077602 @default.
• W2913171106 cites W2024849456 @default.
• W2913171106 cites W2029610231 @default.
• W2913171106 cites W2031023695 @default.
• W2913171106 cites W2038976026 @default.
• W2913171106 cites W2044014818 @default.
• W2913171106 cites W2103355232 @default.
• W2913171106 cites W2104968232 @default.
• W2913171106 cites W2109724619 @default.
• W2913171106 cites W2114296352 @default.
• W2913171106 cites W2120143347 @default.
• W2913171106 cites W2120533615 @default.
• W2913171106 cites W2145659849 @default.
• W2913171106 cites W2149644560 @default.
• W2913171106 cites W2152895485 @default.
• W2913171106 cites W2153669478 @default.
• W2913171106 cites W2240911644 @default.
• W2913171106 cites W2321439693 @default.
• W2913171106 cites W2345010496 @default.
• W2913171106 cites W2346423678 @default.
• W2913171106 cites W2464219688 @default.
• W2913171106 cites W2552304708 @default.
• W2913171106 cites W2624895802 @default.
• W2913171106 cites W2753650690 @default.
• W2913171106 cites W2762843900 @default.
• W2913171106 cites W811995758 @default.
• W2913171106 doi "https://doi.org/10.1038/s41598-019-38558-y" @default.
• W2913171106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6379421" @default.
• W2913171106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30778117" @default.
• W2913171106 hasPublicationYear "2019" @default.
• W2913171106 type Work @default.
• W2913171106 sameAs 2913171106 @default.
• W2913171106 citedByCount "16" @default.
• W2913171106 countsByYear W29131711062020 @default.
• W2913171106 countsByYear W29131711062021 @default.
• W2913171106 countsByYear W29131711062022 @default.
• W2913171106 countsByYear W29131711062023 @default.
• W2913171106 crossrefType "journal-article" @default.
• W2913171106 hasAuthorship W2913171106A5002247726 @default.
• W2913171106 hasAuthorship W2913171106A5016359152 @default.
• W2913171106 hasAuthorship W2913171106A5020651722 @default.
• W2913171106 hasAuthorship W2913171106A5044996960 @default.
• W2913171106 hasAuthorship W2913171106A5058356253 @default.
• W2913171106 hasAuthorship W2913171106A5059985761 @default.
• W2913171106 hasAuthorship W2913171106A5068872463 @default.
• W2913171106 hasAuthorship W2913171106A5073440135 @default.
• W2913171106 hasBestOaLocation W29131711061 @default.
• W2913171106 hasConcept C105572291 @default.
• W2913171106 hasConcept C105702510 @default.
• W2913171106 hasConcept C169760540 @default.
• W2913171106 hasConcept C171056886 @default.
• W2913171106 hasConcept C199215989 @default.
• W2913171106 hasConcept C201750760 @default.
• W2913171106 hasConcept C2778334475 @default.
• W2913171106 hasConcept C2779530196 @default.
• W2913171106 hasConcept C2780775167 @default.
• W2913171106 hasConcept C28328180 @default.
• W2913171106 hasConcept C529278444 @default.
• W2913171106 hasConcept C545706735 @default.
• W2913171106 hasConcept C69125201 @default.
• W2913171106 hasConcept C86803240 @default.
• W2913171106 hasConcept C95444343 @default.
• W2913171106 hasConceptScore W2913171106C105572291 @default.
• W2913171106 hasConceptScore W2913171106C105702510 @default.
• W2913171106 hasConceptScore W2913171106C169760540 @default.
• W2913171106 hasConceptScore W2913171106C171056886 @default.

• next