FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913173009> ?p ?o ?g. }

• W2913173009 endingPage "e0211420" @default.
• W2913173009 startingPage "e0211420" @default.
• W2913173009 abstract "Capsaicin is a natural compound present in chili and red peppers and the responsible of their spicy flavor. It has recently provoked interest because of its antitumoral effects in many cell types although its action mechanism is not clearly understood. As metabolic dysregulation is one of the hallmarks of cancer cells and the key metabolic sensor in the AMP-activated kinase (AMPK), in this study we explored the ability of capsaicin to modulate AMPK activity. We found that capsaicin activated AMPK in HepG2 cells by increasing AMPK phosphorylation and its downstream target ACC. Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase β, CaMKKβ as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK. Moreover, capsaicin decreased cell viability, inhibited Akt/mTOR pathway and increased reactive oxygen species (ROS) in HepG2 cells. AMPK activation was involved in the underpinning mechanism of capsaicin-induced cell death." @default.
• W2913173009 created "2019-02-21" @default.
• W2913173009 creator A5014674098 @default.
• W2913173009 creator A5015917640 @default.
• W2913173009 creator A5033635934 @default.
• W2913173009 creator A5060102998 @default.
• W2913173009 creator A5078847528 @default.
• W2913173009 date "2019-01-29" @default.
• W2913173009 modified "2023-10-17" @default.
• W2913173009 title "The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ" @default.
• W2913173009 cites W1603731054 @default.
• W2913173009 cites W1847014362 @default.
• W2913173009 cites W2019054179 @default.
• W2913173009 cites W2020036405 @default.
• W2913173009 cites W2052543023 @default.
• W2913173009 cites W2065222114 @default.
• W2913173009 cites W2067979493 @default.
• W2913173009 cites W2107770792 @default.
• W2913173009 cites W2114806766 @default.
• W2913173009 cites W2160103929 @default.
• W2913173009 cites W2164778558 @default.
• W2913173009 cites W2174118934 @default.
• W2913173009 cites W2186327842 @default.
• W2913173009 cites W2338835625 @default.
• W2913173009 cites W2342288998 @default.
• W2913173009 cites W2465315499 @default.
• W2913173009 cites W2498811867 @default.
• W2913173009 cites W2548539834 @default.
• W2913173009 cites W2583018095 @default.
• W2913173009 cites W2589600024 @default.
• W2913173009 cites W2605692338 @default.
• W2913173009 cites W2620975370 @default.
• W2913173009 cites W2669522340 @default.
• W2913173009 cites W2750126316 @default.
• W2913173009 cites W2752326209 @default.
• W2913173009 cites W2754409876 @default.
• W2913173009 cites W2757804894 @default.
• W2913173009 cites W2768125705 @default.
• W2913173009 cites W2774462428 @default.
• W2913173009 cites W2805341990 @default.
• W2913173009 cites W2810358408 @default.
• W2913173009 cites W28325062 @default.
• W2913173009 cites W2897912817 @default.
• W2913173009 doi "https://doi.org/10.1371/journal.pone.0211420" @default.
• W2913173009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6350977" @default.
• W2913173009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30695053" @default.
• W2913173009 hasPublicationYear "2019" @default.
• W2913173009 type Work @default.
• W2913173009 sameAs 2913173009 @default.
• W2913173009 citedByCount "14" @default.
• W2913173009 countsByYear W29131730092019 @default.
• W2913173009 countsByYear W29131730092020 @default.
• W2913173009 countsByYear W29131730092021 @default.
• W2913173009 countsByYear W29131730092022 @default.
• W2913173009 crossrefType "journal-article" @default.
• W2913173009 hasAuthorship W2913173009A5014674098 @default.
• W2913173009 hasAuthorship W2913173009A5015917640 @default.
• W2913173009 hasAuthorship W2913173009A5033635934 @default.
• W2913173009 hasAuthorship W2913173009A5060102998 @default.
• W2913173009 hasAuthorship W2913173009A5078847528 @default.
• W2913173009 hasBestOaLocation W29131730091 @default.
• W2913173009 hasConcept C11960822 @default.
• W2913173009 hasConcept C1491633281 @default.
• W2913173009 hasConcept C170493617 @default.
• W2913173009 hasConcept C184235292 @default.
• W2913173009 hasConcept C185592680 @default.
• W2913173009 hasConcept C2776780712 @default.
• W2913173009 hasConcept C2780051329 @default.
• W2913173009 hasConcept C2780124434 @default.
• W2913173009 hasConcept C53227056 @default.
• W2913173009 hasConcept C55493867 @default.
• W2913173009 hasConcept C62478195 @default.
• W2913173009 hasConcept C75217442 @default.
• W2913173009 hasConcept C86554907 @default.
• W2913173009 hasConcept C86803240 @default.
• W2913173009 hasConcept C95444343 @default.
• W2913173009 hasConcept C97029542 @default.
• W2913173009 hasConceptScore W2913173009C11960822 @default.
• W2913173009 hasConceptScore W2913173009C1491633281 @default.
• W2913173009 hasConceptScore W2913173009C170493617 @default.
• W2913173009 hasConceptScore W2913173009C184235292 @default.
• W2913173009 hasConceptScore W2913173009C185592680 @default.
• W2913173009 hasConceptScore W2913173009C2776780712 @default.
• W2913173009 hasConceptScore W2913173009C2780051329 @default.
• W2913173009 hasConceptScore W2913173009C2780124434 @default.
• W2913173009 hasConceptScore W2913173009C53227056 @default.
• W2913173009 hasConceptScore W2913173009C55493867 @default.
• W2913173009 hasConceptScore W2913173009C62478195 @default.
• W2913173009 hasConceptScore W2913173009C75217442 @default.
• W2913173009 hasConceptScore W2913173009C86554907 @default.
• W2913173009 hasConceptScore W2913173009C86803240 @default.
• W2913173009 hasConceptScore W2913173009C95444343 @default.
• W2913173009 hasConceptScore W2913173009C97029542 @default.
• W2913173009 hasFunder F4320323755 @default.
• W2913173009 hasIssue "1" @default.
• W2913173009 hasLocation W29131730091 @default.
• W2913173009 hasLocation W29131730092 @default.
• W2913173009 hasLocation W29131730093 @default.

• next