FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913173819> ?p ?o ?g. }

• W2913173819 abstract "Abstract The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are still poorly understood. Here, we identify heart-resident PDGFRa + Sca-1 + cells as cardiac Fibro/Adipogenic Progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardial infarction (MI) remodeling and leads to improvements in heart function. In the undamaged heart, activation of cFAPs through lineage-specific deletion of the quiescence factor Hic1 reveals additional pathogenic potential, causing fibro-fatty infiltration of the myocardium and driving major pathological features of Arrhythmogenic Cardiomyopathy (AC). Highlights A subpopulation of PDGFRa + , Sca-1 + cells, previously considered to be a sub-type of cardiac fibroblasts, are multipotent mesenchymal progenitors, Cardiac damage triggers the differentiation of PDGFRa + Sca-1 + cells into Sca-1 - cells expressing a fibrogenic transcriptional programme, Blockade of the cFAP-to-fibroblast transition by Nilotinib ameliorated cardiac dysfunction post-MI and modulated cardiac remodelling. Studies performed on a model of experimentally-induced AC confirmed that cFAPs are a source of both cardiac fibroblasts and adipocytes in vivo . Conversely, in the undamaged heart, activation of cFAPs by means of lineage-specific deletion of transcription factor Hic1, resulted in fibro/fatty cardiac degeneration and pathological alterations reminiscent of AC. Collectively, our findings show that a proportion of what are commonly termed “fibroblasts” are actually multipotent mesenchymal progenitors that contribute to different forms of cardiac degeneration depending on the damage setting." @default.
• W2913173819 created "2019-02-21" @default.
• W2913173819 creator A5001686122 @default.
• W2913173819 creator A5005253705 @default.
• W2913173819 creator A5009400254 @default.
• W2913173819 creator A5011676436 @default.
• W2913173819 creator A5019821557 @default.
• W2913173819 creator A5020254533 @default.
• W2913173819 creator A5028375231 @default.
• W2913173819 creator A5033640808 @default.
• W2913173819 creator A5035059587 @default.
• W2913173819 creator A5036327737 @default.
• W2913173819 creator A5037547547 @default.
• W2913173819 creator A5057061459 @default.
• W2913173819 creator A5057227412 @default.
• W2913173819 creator A5057455042 @default.
• W2913173819 creator A5071928972 @default.
• W2913173819 creator A5076531614 @default.
• W2913173819 creator A5085176529 @default.
• W2913173819 date "2019-02-08" @default.
• W2913173819 modified "2023-10-18" @default.
• W2913173819 title "Pathogenic potential of Hic1 expressing cardiac stromal progenitors" @default.
• W2913173819 cites W1574278422 @default.
• W2913173819 cites W1939978733 @default.
• W2913173819 cites W1999310024 @default.
• W2913173819 cites W1999902156 @default.
• W2913173819 cites W2005586230 @default.
• W2913173819 cites W2010253303 @default.
• W2913173819 cites W2015209693 @default.
• W2913173819 cites W2020746336 @default.
• W2913173819 cites W2023680421 @default.
• W2913173819 cites W2024804994 @default.
• W2913173819 cites W2045459581 @default.
• W2913173819 cites W2053717115 @default.
• W2913173819 cites W2063445980 @default.
• W2913173819 cites W2068569386 @default.
• W2913173819 cites W2069417165 @default.
• W2913173819 cites W2094286678 @default.
• W2913173819 cites W2099037109 @default.
• W2913173819 cites W2102928985 @default.
• W2913173819 cites W2116266608 @default.
• W2913173819 cites W2121778435 @default.
• W2913173819 cites W2133465414 @default.
• W2913173819 cites W2136204142 @default.
• W2913173819 cites W2153805086 @default.
• W2913173819 cites W2155698194 @default.
• W2913173819 cites W2156765200 @default.
• W2913173819 cites W2158217645 @default.
• W2913173819 cites W2165160576 @default.
• W2913173819 cites W2166323322 @default.
• W2913173819 cites W2167432612 @default.
• W2913173819 cites W2183587606 @default.
• W2913173819 cites W2343717519 @default.
• W2913173819 cites W2482213414 @default.
• W2913173819 cites W2552848269 @default.
• W2913173819 cites W2583626617 @default.
• W2913173819 cites W2893639967 @default.
• W2913173819 cites W806337263 @default.
• W2913173819 doi "https://doi.org/10.1101/544403" @default.
• W2913173819 hasPublicationYear "2019" @default.
• W2913173819 type Work @default.
• W2913173819 sameAs 2913173819 @default.
• W2913173819 citedByCount "3" @default.
• W2913173819 countsByYear W29131738192019 @default.
• W2913173819 countsByYear W29131738192020 @default.
• W2913173819 countsByYear W29131738192022 @default.
• W2913173819 crossrefType "posted-content" @default.
• W2913173819 hasAuthorship W2913173819A5001686122 @default.
• W2913173819 hasAuthorship W2913173819A5005253705 @default.
• W2913173819 hasAuthorship W2913173819A5009400254 @default.
• W2913173819 hasAuthorship W2913173819A5011676436 @default.
• W2913173819 hasAuthorship W2913173819A5019821557 @default.
• W2913173819 hasAuthorship W2913173819A5020254533 @default.
• W2913173819 hasAuthorship W2913173819A5028375231 @default.
• W2913173819 hasAuthorship W2913173819A5033640808 @default.
• W2913173819 hasAuthorship W2913173819A5035059587 @default.
• W2913173819 hasAuthorship W2913173819A5036327737 @default.
• W2913173819 hasAuthorship W2913173819A5037547547 @default.
• W2913173819 hasAuthorship W2913173819A5057061459 @default.
• W2913173819 hasAuthorship W2913173819A5057227412 @default.
• W2913173819 hasAuthorship W2913173819A5057455042 @default.
• W2913173819 hasAuthorship W2913173819A5071928972 @default.
• W2913173819 hasAuthorship W2913173819A5076531614 @default.
• W2913173819 hasAuthorship W2913173819A5085176529 @default.
• W2913173819 hasBestOaLocation W29131738191 @default.
• W2913173819 hasConcept C122927707 @default.
• W2913173819 hasConcept C142724271 @default.
• W2913173819 hasConcept C16930146 @default.
• W2913173819 hasConcept C198826908 @default.
• W2913173819 hasConcept C201750760 @default.
• W2913173819 hasConcept C2775922572 @default.
• W2913173819 hasConcept C2777420927 @default.
• W2913173819 hasConcept C2780559512 @default.
• W2913173819 hasConcept C28328180 @default.
• W2913173819 hasConcept C37307934 @default.
• W2913173819 hasConcept C502942594 @default.
• W2913173819 hasConcept C71924100 @default.
• W2913173819 hasConcept C86803240 @default.
• W2913173819 hasConcept C95444343 @default.
• W2913173819 hasConceptScore W2913173819C122927707 @default.

• next