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- W2913182246 abstract "Flavonoids are one of the vital classes of bioactive chemicals, abundantly found in plants. These are natural polyphenolic compounds derived from plant metabolites. Their lipophilic nature and poor solubility lead to variable and limited oral bioavailability. The substantial pharmacological properties of flavonoids include antioxidant, anti-inflammatory, antiproliferative, photoprotective, depigmentation, anti-aging which are very promising in the treatment of several skin disorders. Thus, various topical delivery systems of flavonoids have been extensively studied. Mostly, colloidal carriers of flavonoids were reported which are very efficient for topical route with good encapsulation potential, reduced toxicity, and overcome the limitations of conventional dosage forms. This review focuses on various formulations aspects, in vitro characterization and in vivo studies of different classes of flavonoids administered by topical route. Although flavonoids offer tremendous potential in healing the skin conditions categorically, its clinical translation needs in depth safety and efficacy data, meeting established regulatory standards." @default.
- W2913182246 created "2019-02-21" @default.
- W2913182246 creator A5009158083 @default.
- W2913182246 creator A5040473885 @default.
- W2913182246 date "2019-02-01" @default.
- W2913182246 modified "2023-10-16" @default.
- W2913182246 title "Recent advances in topical delivery of flavonoids: A review" @default.
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- W2913182246 doi "https://doi.org/10.1016/j.jconrel.2019.01.029" @default.
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