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- W2913191837 abstract "Bacteriophages are obligate intracellular parasites of bacteria. Some bacteriophages can confer novel bacterial phenotypes, including pathogenicity, through horizontal gene transfer (HGT). The pathogenic bacterium Citrobacter rodentium infects mice using mechanisms similar to those employed by human gastrointestinal pathogens, making it an important model organism. Here, we examined the 10 prophages of C. rodentium , investigating their roles in its evolution toward virulence. We characterized ΦNP and ΦSM, two endogenous active temperate bacteriophages likely important for HGT. We showed that the 10 prophages encode predicted virulence factors and are conserved within other intestinal pathogens. Phylogenetic analysis suggested that they represent a conserved family of horizontally acquired enteric-bacterium-associated pathogenic determinants. Consequently, similar analysis of prophage elements in other pathogens might further understanding of their evolution and pathology." @default.
- W2913191837 created "2019-02-21" @default.
- W2913191837 creator A5012589608 @default.
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- W2913191837 creator A5037071069 @default.
- W2913191837 creator A5091295317 @default.
- W2913191837 date "2019-05-01" @default.
- W2913191837 modified "2023-10-07" @default.
- W2913191837 title "The Prophages of <i>Citrobacter rodentium</i> Represent a Conserved Family of Horizontally Acquired Mobile Genetic Elements Associated with Enteric Evolution towards Pathogenicity" @default.
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- W2913191837 doi "https://doi.org/10.1128/jb.00638-18" @default.
- W2913191837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6456863" @default.
- W2913191837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30782635" @default.
- W2913191837 hasPublicationYear "2019" @default.
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