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- W2913196003 abstract "Aging is associated with sleep–wake disruption, dampening of circadian amplitudes, and a reduced homeostatic sleep response. Aging is also associated with a decline in hypothalamic cell proliferation. We hypothesized that the aging-related decline in cell-proliferation contributes to the dysfunction of preoptic–hypothalamic sleep–wake and circadian systems and consequent sleep–wake disruption. We determined if cytosine-β-D-arabinofuranoside (AraC), an antimitotic agent known to suppress hypothalamic cell proliferation and neurogenesis, causes sleep–wake instability in young mice. The sleep–wake profiles were compared during baseline, during 4 weeks of artificial cerebrospinal fluid (aCSF) + 5-bromo-2′-deoxyuridine (BrdU) or AraC + BrdU infusion into the lateral ventricle, and 8 weeks after treatments. The sleep–wake architecture after AraC treatment was further compared with sleep–wake profiles in aged mice. Compared to aCSF + BrdU, 4 weeks of AraC + BrdU infusion significantly decreased (− 96%) the number of BrdU + cells around the third ventricular wall and adjacent preoptic–hypothalamic area and produced a) sleep disruption during the light phase with decreases in non-rapid eye movement (nonREM) (− 9%) and REM sleep (− 21%) amounts, and increased numbers of shorter (< 2 min; 142 versus 98 episodes/12 h) and decreased numbers of longer (> 5 min; 19 versus 26 episodes/12 h) nonREM sleep episodes; and b) wake disruption during the dark phase, with increased numbers of shorter (138 versus 91 episodes/12 h) and decreased numbers of longer active waking (17 versus 24 episodes/12 h) episodes. AraC-treated mice also exhibited lower delta activity within nonREM recovery sleep. The sleep–wake architecture of AraC-treated mice was similar to that observed in aged mice. These findings are consistent with a hypothesis that a decrease in hypothalamic cell proliferation/neurogenesis is detrimental to sleep–wake and circadian systems and may underlie sleep–wake disturbance in aging." @default.
- W2913196003 created "2019-02-21" @default.
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- W2913196003 date "2019-04-01" @default.
- W2913196003 modified "2023-10-17" @default.
- W2913196003 title "Chronic Suppression of Hypothalamic Cell Proliferation and Neurogenesis Induces Aging-Like Changes in Sleep–Wake Organization in Young Mice" @default.
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- W2913196003 doi "https://doi.org/10.1016/j.neuroscience.2019.01.053" @default.
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