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• W2913213057 abstract "Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defined, especially upon chronic exposure to IL-33. Mimicking the inflammatory milieu of skin disorders, we found that persistent exposure to IL-33 (over a 5-week period) strengthened skin MC numbers through accelerated cell-cycle progression and restriction of apoptosis. Conversely, IL-33 attenuated degranulation and FcεRI expression, potentially as a feedback to chronic “alarmin” exposure. Interestingly, the negative impact on histamine release was counterbalanced by amplified histamine production. Considering the clinical significance of histamine and scarce information on its regulation, we explored the molecular underpinnings. IL-33 induced swift phosphorylation of p38 and JNK (but not of ERK1/2 or AKT), and stimulated histidine decarboxylase expression. Combining pharmacological inhibition and kinase elimination by Accell-facilitated RNA interference in skin MCs revealed a p38-dependent, but JNK-independent mechanism. Collectively, IL-33 exerts multifaceted effects on cutaneous MCs at a post-maturation stage. The IL-33–skin MC axis may contribute to and balance inflammation in chronic skin disorders. Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defined, especially upon chronic exposure to IL-33. Mimicking the inflammatory milieu of skin disorders, we found that persistent exposure to IL-33 (over a 5-week period) strengthened skin MC numbers through accelerated cell-cycle progression and restriction of apoptosis. Conversely, IL-33 attenuated degranulation and FcεRI expression, potentially as a feedback to chronic “alarmin” exposure. Interestingly, the negative impact on histamine release was counterbalanced by amplified histamine production. Considering the clinical significance of histamine and scarce information on its regulation, we explored the molecular underpinnings. IL-33 induced swift phosphorylation of p38 and JNK (but not of ERK1/2 or AKT), and stimulated histidine decarboxylase expression. Combining pharmacological inhibition and kinase elimination by Accell-facilitated RNA interference in skin MCs revealed a p38-dependent, but JNK-independent mechanism. Collectively, IL-33 exerts multifaceted effects on cutaneous MCs at a post-maturation stage. The IL-33–skin MC axis may contribute to and balance inflammation in chronic skin disorders." @default.
• W2913213057 created "2019-02-21" @default.
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• W2913213057 date "2019-07-01" @default.
• W2913213057 modified "2023-10-01" @default.
• W2913213057 title "Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation" @default.
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• W2913213057 cites W1964053655 @default.
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• W2913213057 cites W1967436625 @default.
• W2913213057 cites W1967629432 @default.
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• W2913213057 cites W1972541045 @default.
• W2913213057 cites W1972940632 @default.
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• W2913213057 cites W1986364099 @default.
• W2913213057 cites W1988035869 @default.
• W2913213057 cites W2007040021 @default.
• W2913213057 cites W2012512942 @default.
• W2913213057 cites W2015061237 @default.
• W2913213057 cites W2021557819 @default.
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• W2913213057 cites W2035585307 @default.
• W2913213057 cites W2037312785 @default.
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• W2913213057 cites W2039112412 @default.
• W2913213057 cites W2044504507 @default.
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• W2913213057 cites W2162814462 @default.
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• W2913213057 doi "https://doi.org/10.1016/j.jid.2019.01.013" @default.
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