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- W2913219231 abstract "The present study investigated the effect of early life stress in adolescent rats on brain metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. Behavioral tests, serum corticosterone and high-resolution proton magnetic resonance spectroscopy were conducted between PND 30 and 40. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. They also showed reduced glutamate, glutamine, and N-acetylaspartate (NAA) levels in the prefrontal cortex. A reduced myo-inositol level, consistent with astroglial deficits, was observed but was not statistically significant. Together, these findings characterize the effect of early life stress on adolescent animals and underscore the long-lasting and detrimental effects of childhood adversities." @default.
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- W2913219231 date "2019-01-01" @default.
- W2913219231 modified "2023-09-25" @default.
- W2913219231 title "Early-life stress affects microglia, possible modulation by dietary fatty acids" @default.
- W2913219231 doi "https://doi.org/10.1016/j.euroneuro.2018.11.772" @default.
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