FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913223786> ?p ?o ?g. }

• W2913223786 abstract "Colistin is used as an alternative therapeutic for carbapenemase-producing Enterobacteriaceae (CPE) infections which are spreading at a very high rate due to the transfer of carbapenemase genes through mobile genetic elements. Due to the emergence of mcr-1, the plasmid-mediated colistin resistance gene, mcr-1-positive Enterobacteriaceae (MCRPEn) pose a high risk for the transfer of mcr-1-carrying plasmid to CPE, leading to a situation with no treatment alternatives for infections caused by Enterobacteriaceae possessing both mcr-1 and carbapenemase genes. Here, we report the application of PCR-dipstick-oriented surveillance strategy to control MCRPEn and CPE by conducting the PCR-dipstick technique for the detection of MCRPEn and CPE in a tertiary care hospital in Thailand and comparing its efficacy with conventional surveillance method. Our surveillance results showed a high MCRPEn (5.9%) and CPE (8.7%) carriage rate among the 219 rectal swab specimens examined. Three different CPE clones were determined by pulsed-field gel electrophoresis whereas only two MCRPEn isolates were found to be closely related as shown by single nucleotide polymorphism-based phylogenetic analysis. Whole genome sequencing and plasmid analysis showed that MCRPEn carried mcr-1 in two plasmids types – IncX4 and IncI2 with ~99% identity to the previously reported mcr-1-carrying plasmids. The identification of both MCRPEn and CPE in the same specimen indicates the plausibility of plasmid-mediated transfer of mcr-1 genes leading to the emergence of colistin- and carbapenem-resistant Enterobacteriaceae. The rapidity (< 2 h) and robust sensitivity (100%)/specificity (~99%) of PCR-dipstick show that this specimen-direct screening method could aid in implementing infection control measures at the earliest to control the dissemination of MCRPEn and CPE." @default.
• W2913223786 created "2019-02-21" @default.
• W2913223786 creator A5006845416 @default.
• W2913223786 creator A5007448777 @default.
• W2913223786 creator A5014191476 @default.
• W2913223786 creator A5016697783 @default.
• W2913223786 creator A5022022939 @default.
• W2913223786 creator A5030041464 @default.
• W2913223786 creator A5030499067 @default.
• W2913223786 creator A5038683477 @default.
• W2913223786 creator A5038945192 @default.
• W2913223786 creator A5054383277 @default.
• W2913223786 creator A5057290198 @default.
• W2913223786 creator A5060123443 @default.
• W2913223786 creator A5060354323 @default.
• W2913223786 creator A5067606610 @default.
• W2913223786 creator A5073188851 @default.
• W2913223786 creator A5081994238 @default.
• W2913223786 creator A5084205851 @default.
• W2913223786 creator A5086025444 @default.
• W2913223786 date "2019-02-08" @default.
• W2913223786 modified "2023-09-29" @default.
• W2913223786 title "PCR-Dipstick-Oriented Surveillance and Characterization of mcr-1- and Carbapenemase-Carrying Enterobacteriaceae in a Thai Hospital" @default.
• W2913223786 cites W1809272191 @default.
• W2913223786 cites W1840351646 @default.
• W2913223786 cites W2032519858 @default.
• W2913223786 cites W2065337857 @default.
• W2913223786 cites W2097005840 @default.
• W2913223786 cites W2116245384 @default.
• W2913223786 cites W2117043113 @default.
• W2913223786 cites W2134852597 @default.
• W2913223786 cites W2143325926 @default.
• W2913223786 cites W2167826782 @default.
• W2913223786 cites W2179036997 @default.
• W2913223786 cites W2298295860 @default.
• W2913223786 cites W2396597555 @default.
• W2913223786 cites W2475041682 @default.
• W2913223786 cites W2511020653 @default.
• W2913223786 cites W2513238037 @default.
• W2913223786 cites W2524156053 @default.
• W2913223786 cites W2549386483 @default.
• W2913223786 cites W2555135577 @default.
• W2913223786 cites W2566804390 @default.
• W2913223786 cites W2578005172 @default.
• W2913223786 cites W2580056287 @default.
• W2913223786 cites W2582776852 @default.
• W2913223786 cites W2584306356 @default.
• W2913223786 cites W2586735881 @default.
• W2913223786 cites W2587845501 @default.
• W2913223786 cites W2588598303 @default.
• W2913223786 cites W2593444269 @default.
• W2913223786 cites W2597991812 @default.
• W2913223786 cites W2604303732 @default.
• W2913223786 cites W2616295139 @default.
• W2913223786 cites W2620716579 @default.
• W2913223786 cites W2622768456 @default.
• W2913223786 cites W2624964421 @default.
• W2913223786 cites W2727382675 @default.
• W2913223786 cites W2735947590 @default.
• W2913223786 cites W2736979481 @default.
• W2913223786 cites W2757076185 @default.
• W2913223786 cites W2761317351 @default.
• W2913223786 cites W2763294214 @default.
• W2913223786 cites W2763570542 @default.
• W2913223786 cites W2766030047 @default.
• W2913223786 cites W2770937934 @default.
• W2913223786 cites W2790058700 @default.
• W2913223786 cites W2794814363 @default.
• W2913223786 cites W2796372426 @default.
• W2913223786 cites W2801139450 @default.
• W2913223786 cites W2802068594 @default.
• W2913223786 cites W2949907272 @default.
• W2913223786 doi "https://doi.org/10.3389/fmicb.2019.00149" @default.
• W2913223786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6375898" @default.
• W2913223786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30800104" @default.
• W2913223786 hasPublicationYear "2019" @default.
• W2913223786 type Work @default.
• W2913223786 sameAs 2913223786 @default.
• W2913223786 citedByCount "15" @default.
• W2913223786 countsByYear W29132237862020 @default.
• W2913223786 countsByYear W29132237862021 @default.
• W2913223786 countsByYear W29132237862022 @default.
• W2913223786 countsByYear W29132237862023 @default.
• W2913223786 crossrefType "journal-article" @default.
• W2913223786 hasAuthorship W2913223786A5006845416 @default.
• W2913223786 hasAuthorship W2913223786A5007448777 @default.
• W2913223786 hasAuthorship W2913223786A5014191476 @default.
• W2913223786 hasAuthorship W2913223786A5016697783 @default.
• W2913223786 hasAuthorship W2913223786A5022022939 @default.
• W2913223786 hasAuthorship W2913223786A5030041464 @default.
• W2913223786 hasAuthorship W2913223786A5030499067 @default.
• W2913223786 hasAuthorship W2913223786A5038683477 @default.
• W2913223786 hasAuthorship W2913223786A5038945192 @default.
• W2913223786 hasAuthorship W2913223786A5054383277 @default.
• W2913223786 hasAuthorship W2913223786A5057290198 @default.
• W2913223786 hasAuthorship W2913223786A5060123443 @default.
• W2913223786 hasAuthorship W2913223786A5060354323 @default.
• W2913223786 hasAuthorship W2913223786A5067606610 @default.
• W2913223786 hasAuthorship W2913223786A5073188851 @default.
• W2913223786 hasAuthorship W2913223786A5081994238 @default.

• next