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• W2913232887 abstract "Abstract Aim To evaluate the use of recombinant human fibroblast growth factor (rh FGF )‐2 in combination with deproteinized bovine bone mineral ( DBBM ) compared with rh FGF ‐2 alone, in the treatment of intrabony periodontal defects. Materials and Methods Patients with periodontitis who had received initial periodontal therapy and had intrabony defects of ≥ 3 mm in depth were enrolled. Sites were randomly assigned to receive a commercial formulation of 0.3% rh FGF ‐2 + DBBM (test) or rh FGF ‐2 alone (control). Clinical parameters and a patient‐reported outcome measure ( PROM ) were evaluated at baseline and at 3 and 6 months postoperatively. Results Twenty‐two sites in each group were evaluated. A significant improvement in clinical attachment level ( CAL ) from baseline was observed in both groups at 6 months postoperatively. CAL gain was 3.16 ± 1.45 mm in the test group and 2.77 ± 1.15 mm in the control group, showing no significant difference between groups. Radiographic bone fill was significantly greater in the test group (47.2%) than in the control group (29.3%). No significant difference in PROM between groups was observed. Conclusions At 6 months, no significant difference in CAL gain or PROM between the two treatments was observed, although combination therapy yielded an enhanced radiographic outcome." @default.
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• W2913232887 date "2019-03-01" @default.
• W2913232887 modified "2023-09-25" @default.
• W2913232887 title "Treatment of intrabony periodontal defects using rh <scp>FGF</scp> ‐2 in combination with deproteinized bovine bone mineral or rh <scp>FGF</scp> ‐2 alone: A 6‐month randomized controlled trial" @default.
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• W2913232887 doi "https://doi.org/10.1111/jcpe.13086" @default.
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