Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913237324> ?p ?o ?g. }
- W2913237324 endingPage "e1007899" @default.
- W2913237324 startingPage "e1007899" @default.
- W2913237324 abstract "Translationally Controlled Tumor Protein (TCTP) controls growth by regulating the G1/S transition during cell cycle progression. Our genetic interaction studies show that TCTP fulfills this role by interacting with CSN4, a subunit of the COP9 Signalosome complex, known to influence CULLIN-RING ubiquitin ligases activity by controlling CULLIN (CUL) neddylation status. In agreement with these data, downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP, respectively, demonstrating a conserved mechanism between plants and animals. Together, our data show that CSN4 is the missing factor linking TCTP to the control of cell cycle progression and cell proliferation during organ development and open perspectives towards understanding TCTP’s role in organ development and disorders associated with TCTP miss-expression." @default.
- W2913237324 created "2019-02-21" @default.
- W2913237324 creator A5001271605 @default.
- W2913237324 creator A5004168613 @default.
- W2913237324 creator A5008492856 @default.
- W2913237324 creator A5012399051 @default.
- W2913237324 creator A5012809287 @default.
- W2913237324 creator A5036817291 @default.
- W2913237324 creator A5050188812 @default.
- W2913237324 creator A5056568485 @default.
- W2913237324 creator A5065623920 @default.
- W2913237324 creator A5069581070 @default.
- W2913237324 creator A5076735451 @default.
- W2913237324 creator A5077070444 @default.
- W2913237324 creator A5086776838 @default.
- W2913237324 creator A5091802328 @default.
- W2913237324 date "2019-01-29" @default.
- W2913237324 modified "2023-10-18" @default.
- W2913237324 title "TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals" @default.
- W2913237324 cites W1432796019 @default.
- W2913237324 cites W1541556706 @default.
- W2913237324 cites W1608387203 @default.
- W2913237324 cites W1861165793 @default.
- W2913237324 cites W1981192346 @default.
- W2913237324 cites W1981423208 @default.
- W2913237324 cites W1988371352 @default.
- W2913237324 cites W1993032964 @default.
- W2913237324 cites W1996545881 @default.
- W2913237324 cites W2004023148 @default.
- W2913237324 cites W2005124332 @default.
- W2913237324 cites W2008642796 @default.
- W2913237324 cites W2012968622 @default.
- W2913237324 cites W2013765023 @default.
- W2913237324 cites W2021010322 @default.
- W2913237324 cites W2026459518 @default.
- W2913237324 cites W2027783756 @default.
- W2913237324 cites W2035029147 @default.
- W2913237324 cites W2043285596 @default.
- W2913237324 cites W2047607873 @default.
- W2913237324 cites W2047750593 @default.
- W2913237324 cites W2047882742 @default.
- W2913237324 cites W2050723187 @default.
- W2913237324 cites W2053763318 @default.
- W2913237324 cites W2057280876 @default.
- W2913237324 cites W2059008362 @default.
- W2913237324 cites W2059082923 @default.
- W2913237324 cites W2060687391 @default.
- W2913237324 cites W2061118558 @default.
- W2913237324 cites W2061221432 @default.
- W2913237324 cites W2076493773 @default.
- W2913237324 cites W2080502894 @default.
- W2913237324 cites W2083025900 @default.
- W2913237324 cites W2083825286 @default.
- W2913237324 cites W2091500532 @default.
- W2913237324 cites W2096991671 @default.
- W2913237324 cites W2101802442 @default.
- W2913237324 cites W2103248609 @default.
- W2913237324 cites W2105618655 @default.
- W2913237324 cites W2108935540 @default.
- W2913237324 cites W2110643873 @default.
- W2913237324 cites W2122743214 @default.
- W2913237324 cites W2123263831 @default.
- W2913237324 cites W2123641977 @default.
- W2913237324 cites W2128635872 @default.
- W2913237324 cites W2130635437 @default.
- W2913237324 cites W2131709002 @default.
- W2913237324 cites W2132056415 @default.
- W2913237324 cites W2139587743 @default.
- W2913237324 cites W2140871956 @default.
- W2913237324 cites W2141429272 @default.
- W2913237324 cites W2142192445 @default.
- W2913237324 cites W2142883760 @default.
- W2913237324 cites W2147109973 @default.
- W2913237324 cites W2149860768 @default.
- W2913237324 cites W2151825126 @default.
- W2913237324 cites W2156310559 @default.
- W2913237324 cites W2159381580 @default.
- W2913237324 cites W2167686263 @default.
- W2913237324 cites W2168594045 @default.
- W2913237324 cites W2313629931 @default.
- W2913237324 cites W2341901950 @default.
- W2913237324 cites W2396528478 @default.
- W2913237324 cites W2415750945 @default.
- W2913237324 cites W2484722645 @default.
- W2913237324 cites W2600375405 @default.
- W2913237324 cites W2768590823 @default.
- W2913237324 cites W4293247451 @default.
- W2913237324 doi "https://doi.org/10.1371/journal.pgen.1007899" @default.
- W2913237324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368322" @default.
- W2913237324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30695029" @default.
- W2913237324 hasPublicationYear "2019" @default.
- W2913237324 type Work @default.
- W2913237324 sameAs 2913237324 @default.
- W2913237324 citedByCount "17" @default.
- W2913237324 countsByYear W29132373242019 @default.
- W2913237324 countsByYear W29132373242020 @default.
- W2913237324 countsByYear W29132373242021 @default.
- W2913237324 countsByYear W29132373242022 @default.