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- W2913247003 abstract "Local anaesthetics prevent the transmission of nerve impulses from nociceptive afferents, thereby reducing the perception of pain. According to their chemical structure, they are classed as amide or ester local anaesthetics. Their use in plastic and reconstructive surgery is widespread. This chapter explores the basic classification of local anaesthetics, their physiochemical, pharmacokinetic and pharmacodynamic profiles, and the relevance of these properties to clinical practice. The rationale and application of local anaesthetic adjuncts, as well as the evolving technology in the field of topical local anaesthetic delivery systems is also discussed. The clinical syndrome of local anaesthetic systemic toxicity is explored, with emphasis on recognition, treatment and prevention. Finally, the technique of intravenous regional anaesthesia and frequently used facial blocks are outlined." @default.
- W2913247003 created "2019-02-21" @default.
- W2913247003 creator A5010306306 @default.
- W2913247003 date "2015-03-27" @default.
- W2913247003 modified "2023-09-26" @default.
- W2913247003 title "Local anaesthetics" @default.
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- W2913247003 doi "https://doi.org/10.1002/9781118655412.ch4" @default.
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