FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913249572> ?p ?o ?g. }

• W2913249572 endingPage "13" @default.
• W2913249572 startingPage "1" @default.
• W2913249572 abstract "Obesity is a major risk factor for many chronic diseases, including diabetes, fatty livers, and cancer. Expansion of the adipose mass has been shown to be related to adipogenic differentiation of adipose-derived mesenchymal stem cells (ASCs). However, the underlying mechanism of this effect has yet to be elucidated. We found that osteopontin (OPN) is downregulated in ASCs and adipose tissues of obese mice and overweight human beings because of methylation on its promoter, indicating that OPN may affect the development of obesity. Silencing of OPN in wild-type ASCs promotes adipogenic differentiation, while reexpression of OPN reduced adipogenic differentiation in OPN −/− ASCs. The role of extracellular OPN in ASC differentiation was further demonstrated by supplementation and neutralization of OPN. Additionally, OPN suppresses adipogenic differentiation in ASCs through the C/EBP pathways. Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity. Therefore, our study demonstrates an important role of OPN in regulating the development of obesity, indicating OPN might be a novel target to attenuate obesity and its complications." @default.
• W2913249572 created "2019-02-21" @default.
• W2913249572 creator A5006492155 @default.
• W2913249572 creator A5012641434 @default.
• W2913249572 creator A5025690046 @default.
• W2913249572 creator A5039213269 @default.
• W2913249572 creator A5049692788 @default.
• W2913249572 creator A5053453125 @default.
• W2913249572 creator A5061972961 @default.
• W2913249572 creator A5068776211 @default.
• W2913249572 creator A5073459173 @default.
• W2913249572 creator A5077671701 @default.
• W2913249572 creator A5080102032 @default.
• W2913249572 creator A5084547085 @default.
• W2913249572 date "2019-02-17" @default.
• W2913249572 modified "2023-10-17" @default.
• W2913249572 title "Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells" @default.
• W2913249572 cites W1670890407 @default.
• W2913249572 cites W1976371737 @default.
• W2913249572 cites W1978454776 @default.
• W2913249572 cites W1991671784 @default.
• W2913249572 cites W1997572210 @default.
• W2913249572 cites W2003389247 @default.
• W2913249572 cites W2007638378 @default.
• W2913249572 cites W2016064855 @default.
• W2913249572 cites W2016701686 @default.
• W2913249572 cites W2038961236 @default.
• W2913249572 cites W2039153962 @default.
• W2913249572 cites W2064433079 @default.
• W2913249572 cites W2069939919 @default.
• W2913249572 cites W2082142704 @default.
• W2913249572 cites W2087029190 @default.
• W2913249572 cites W2116546975 @default.
• W2913249572 cites W2132378346 @default.
• W2913249572 cites W2139440574 @default.
• W2913249572 cites W2152377123 @default.
• W2913249572 cites W2159168546 @default.
• W2913249572 cites W2159999899 @default.
• W2913249572 cites W2164921446 @default.
• W2913249572 cites W2166016923 @default.
• W2913249572 cites W2166389246 @default.
• W2913249572 cites W2189577815 @default.
• W2913249572 cites W2271797997 @default.
• W2913249572 cites W2332018470 @default.
• W2913249572 cites W2339923640 @default.
• W2913249572 cites W2376741234 @default.
• W2913249572 cites W2392264761 @default.
• W2913249572 cites W2526727674 @default.
• W2913249572 cites W2554183552 @default.
• W2913249572 cites W2560839926 @default.
• W2913249572 cites W2562127490 @default.
• W2913249572 cites W2587344758 @default.
• W2913249572 doi "https://doi.org/10.1155/2019/1238153" @default.
• W2913249572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6398038" @default.
• W2913249572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30911298" @default.
• W2913249572 hasPublicationYear "2019" @default.
• W2913249572 type Work @default.
• W2913249572 sameAs 2913249572 @default.
• W2913249572 citedByCount "5" @default.
• W2913249572 countsByYear W29132495722020 @default.
• W2913249572 countsByYear W29132495722022 @default.
• W2913249572 countsByYear W29132495722023 @default.
• W2913249572 crossrefType "journal-article" @default.
• W2913249572 hasAuthorship W2913249572A5006492155 @default.
• W2913249572 hasAuthorship W2913249572A5012641434 @default.
• W2913249572 hasAuthorship W2913249572A5025690046 @default.
• W2913249572 hasAuthorship W2913249572A5039213269 @default.
• W2913249572 hasAuthorship W2913249572A5049692788 @default.
• W2913249572 hasAuthorship W2913249572A5053453125 @default.
• W2913249572 hasAuthorship W2913249572A5061972961 @default.
• W2913249572 hasAuthorship W2913249572A5068776211 @default.
• W2913249572 hasAuthorship W2913249572A5073459173 @default.
• W2913249572 hasAuthorship W2913249572A5077671701 @default.
• W2913249572 hasAuthorship W2913249572A5080102032 @default.
• W2913249572 hasAuthorship W2913249572A5084547085 @default.
• W2913249572 hasBestOaLocation W29132495721 @default.
• W2913249572 hasConcept C104317684 @default.
• W2913249572 hasConcept C122927707 @default.
• W2913249572 hasConcept C126322002 @default.
• W2913249572 hasConcept C134018914 @default.
• W2913249572 hasConcept C150194340 @default.
• W2913249572 hasConcept C171089720 @default.
• W2913249572 hasConcept C185592680 @default.
• W2913249572 hasConcept C190727270 @default.
• W2913249572 hasConcept C198826908 @default.
• W2913249572 hasConcept C2780804394 @default.
• W2913249572 hasConcept C502942594 @default.
• W2913249572 hasConcept C55493867 @default.
• W2913249572 hasConcept C71924100 @default.
• W2913249572 hasConcept C86803240 @default.
• W2913249572 hasConcept C95444343 @default.
• W2913249572 hasConceptScore W2913249572C104317684 @default.
• W2913249572 hasConceptScore W2913249572C122927707 @default.
• W2913249572 hasConceptScore W2913249572C126322002 @default.
• W2913249572 hasConceptScore W2913249572C134018914 @default.
• W2913249572 hasConceptScore W2913249572C150194340 @default.
• W2913249572 hasConceptScore W2913249572C171089720 @default.
• W2913249572 hasConceptScore W2913249572C185592680 @default.

• next